ROLE OF LECTIN-SUBSTRANCE RECOGNITION IN IMMUNOREGULATORY INTERACTION BETWEEN INTERLEUKIN-2 IGG
https://doi.org/10.15789/1563-0625-2010-1-2-13-20
Abstract
As assessed by decreased response of ConA-induced blasts to IL-2, a staphylococcal protein A was shown to extract IL-2 from cultural medium after its preincubation with IgG, but it did not bind pure IL-2. Normal human immunoglobulin inhibits reaction of DTH effectors to Listeria antigen, which is also IL-2-dependent. An immunomodulating drug Phosprenyl (sodium polyprenylphosphate) abolishes the inhibitory ffect of immunoglobulin. Since Phosprenyl (as shown earlier) interacts with alpha-chain of rIL-2 and blocks IL-2 activity, the two drugs are in competitive relations. The latter may be explained by identities in prostetic carbohydrate groups of the both glycoproteins (CD25 and immunoglobulin), whereas Phosprenyl and IL-2 would behave like as lectins. These results characterize local conditions and mechanisms of immune regulation under tissue domination of gamma-globulin or antibodies of a given isotype. IgG binds with IL-2, reacting not with an active center but with effector region of IgG molecule, thus blocking IL-2 activity. Since a similar effect is observed under in vivo conditions (in a DTH model), the phenomenon revealed may explein inhibition of immune response after passive injection of antibodies, as well as a feed-back relationship between humoral and cellular immunity. Inhibition of IL-2 biological activity after its interaction with IgG and immune complexes may be considered as a universal mechanism of immune regulation performed by a feedback regulation, which may be influenced by means of Phosprenyl-like immunomodulators. In some infections, malignant growth etc., such mechanism may be of utmost pathogenetic significance. Moreover, such a mechanism cannot be also excluded in some physiological immunogenetic interactions, e.g., in feto-maternal system, where it could promote a positive selection for individuals with broader MHC repertoire, which would be necessary for development of individual and population-based resistance to infections
About the Authors
S. M. Sobolev
Отдел иммунологии НИИ эпидемиологии и микробиологии им. Н.Ф. Гамалеи РАМН, Москва
Russian Federation
Russian Federation
T. N. Nikolaeva
Отдел иммунологии НИИ эпидемиологии и микробиологии им. Н.Ф. Гамалеи РАМН, Москва
Russian Federation
Russian Federation
E. A. Grigorjeva
Отдел иммунологии НИИ эпидемиологии и микробиологии им. Н.Ф. Гамалеи РАМН, Москва
Russian Federation
Russian Federation
A. V. Pronin
Отдел иммунологии НИИ эпидемиологии и микробиологии им. Н.Ф. Гамалеи РАМН, Москва
Russian Federation
Russian Federation
References
1. Наровлянский А.Н., Васильев А.Н., Савойская С.Л., Иванова А.М., Изместьева А.В., Данилов Л.Л., Веселовский В.В., Ожерелков С.В.,Зубашев И.К., Пронин А.В., Санин А.В., Ершов Ф .И. Система изопреноидов: роль в противовирусном иммунитете // Ведомости НЦ экспертизы средств медицинского применения. –2007. – № 3. – С. 66-75.
2. Bayry J., Lacroix-Desmazes S., Caboneil C., Misra N., Donkova V., Pashov A., Chevailler A., Mouthon L., Weill B., Bruneval P., Kazatchkine M.D., Kaveri S.V. Inhibition of maturation and function of dendritic cells by intravenous immunoglobulin // Blood. – 2003. – Vol. 101, N 2. – P. 758-765.
3. Doebis C., Siegmund K., Loddenkemper C., Lowe J.B., Issekutz A.C., Hamann A., Huehn J., Syrbe U. Cellular Players and Role of Selectin Ligands in Leukocyte Recruitment in a T Cell-Initiated Delayed- Type Hypersensitivity Reaction // Amer. J. Pathol. – 2008. – Vol. 173, N 4. – P. 1067-1076.
4. Galeotti C., Maddur M.S., Kazatchkine M.D., Mouthon L., Kaveri S.V. Mechanisms of action of IVIG in autoimmune and inflammatory disorders: recent developments // Transfus. Clin. Biol. – 2009. – Vol. 16, N 2. – P. 75-79.
5. Gupta M., Noel G.J., Schaefer M., Friedman D., Bussel J., Johann-Liang R. Cytokine modulation with immune gamma-globulin in peripheral blood of normal children and its implications in Kawasaki disease treatment // J. Clin. Immunol. – 2001. – Vol. 21, N 3. – P. 193-199.
6. Kessler S.W. Rapid isolation of antigens from cells with a Staphylococcus protein A – antibody adsorbent: parameters of the interaction of antibodyantigen complexes with protein A // J. Immunol. – 1975. – Vol. 115, N 6. – P. 1617-1624.
7. Marth J.D., Grewal P.K. Mammalian glycosylation in immunity // Nature Reviews Immunology. – 2008. – Vol. 8, N 11. – P. 884-887.
8. Modiano J.F., Amran D., Lack G., Bradley K., Ball C., Domenico J., Gelfand E.W. Posttranscriptional regulation of T cell IL-2 production by human pooled immunoglobulin //Clin. Immunol. Immunopathol. – 1997. – Vol. 83, N 1. – P. 77-85.
9. Nachbaur D., Herold M., Eibl B.,Glassl H., Schwaighofer H., Huber C., Gachter A. A comparative study of the in vitro immunomodulatory activity of human intact immunoglobulin (7S IVIG), F(ab’)2 fragments (5S IVIG) and Fc fragments. Evidence for posttranscriptional IL-2 modulation // Immunology. – 1997. – Vol. 90. – P. 212-218.
10. Pronin A.V., Ozherelkov S.V., Narovlyansky A.N., Danilov L.L., Maltsev S.D., Deyeva A.V., Grigorieva E.A., Sanin A.V. Role of cytokines in immunomodulatory effects of polyprenyl phosphate: new generation of antiviral drugs // Russian J. Imuunol. – 2000. – Vol. 5, N 2. – P. 156-164.
11. Siberil S., Elluru S., Graff-Dubois S., Negi V.S., Delignat S., Mouthon L., Lacroix-Desmazes S., Kazatchkine M.D., Bayary J., Kaveri S.V. Intravenous immunoglobulins in autoimmune and inflammatory deseases: a mechanistic perspective // Ann. N.Y. Acad. Sci. – 2007. – Vol. 1110. – P. 497-506.
12. Sobolev S.M., Pronin A.V. Functional and serological evidences of the non-immune interaction of interleukin-2 and immunoglobulin G // Russian J. Imuunol. – 2000. – Vol. 5, N 2. – P. 203-208.
13. Szereday L., Spath P., Szekeres-Bartho J. Natural killer activity and cytokine production after in vitro immunoglobulin treatment of lymphocytes derived from pregnant women with or without risk for spontaneous abortion // Am. J. Reprod. Immunol. – 1999 – Vol. 42, N 5. – P. 282-287.
14. Vani J., Elluru S., Negi V.S., Lacroix-Desmazes S., Kazatchkine M.D., Bayary J., Kaveri S.V. Role of natural antibodies in immune homeostasis: IVIg perspective // Autoimmun. Rev. – 2008. – Vol. 7, N 6. – P. 440-444.
15. Wu K.H., Wu W.M., Lu M.Y., Chiang B.L. Inhibitory effect of pooled human immunoglobulin on cytokine production in peripheral blood mononuclear cells // Pediatr. Allergy Immunol. – 2006. – Vol. 17, N 1. – P. 60-68.
Review
For citations:
Sobolev S.M., Nikolaeva T.N., Grigorjeva E.A., Pronin A.V. ROLE OF LECTIN-SUBSTRANCE RECOGNITION IN IMMUNOREGULATORY INTERACTION BETWEEN INTERLEUKIN-2 IGG. Medical Immunology (Russia). 2010;12(1-2):13-20. (In Russ.) https://doi.org/10.15789/1563-0625-2010-1-2-13-20
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