CORRECTION OF IMMUNE DISORDERS IN ACUTE PYELONE-FRITS IN DIFFERENT TRIMESTERS OF PREGNANCY

Abstract

Introduction. The issues of pathogenetic and restorative therapy of gestational pyelonephritis during pregnancy are relevant and debatable in modern evidence-based medicine. Treatment of these patients is associated with certain subtleties, since during pregnancy it is necessary not only to provide for the relief of the inflammatory process in the mother's urinary system, but also, using pharmacological agents, not to harm the health of the future child. This problem is characterized by an annual increase in morbidity and complications, which often have an extremely negative effect on the course of pregnancy and childbirth in 3-17% of women of childbearing age in Russia annually.

Purpose of the study: to determine the effectiveness of using Viferon in stabilizing immune disorders in gestational pyelonephritis.

Material and methods. The study included 80 women (mean age 32.4±3.7 years) divided into groups: control (consisting of healthy non-pregnant female volunteers), two groups with acute pyelonephritis in the second and third trimesters of pregnancy, receiving basic therapy, and two groups of pregnant women with a combination of basic treatment and the immunomodulator Viferon. The cytokine spectrum, the state of the complement system and the functional-metabolic activity of neutrophils were studied in the circulating peripheral blood. Blood was taken before the start of complex treatment, i.e. immediately upon admission and after the treatment, i.e. upon discharge from the hospital, with the achieved signs of clinical relief of the disease.

Results. More effective relief of immune inflammation of acute pyelonephritis was revealed when using Viferon in the 2nd and 3rd trimesters of pregnancy compared to traditional therapy. The proposed treatment method allows for faster normalization of altered immune status parameters and the fastest clinical recovery of patients. The use of this method in medical practice with traditional therapy is a relevant, safe and effective method for treating acute gestational pyelonephritis, which will reduce the incidence of obstetric and urological complications, reduce the number of hospital stays in a medical institution, reduce the cost of hospital stay, improve the quality of life of pregnant women and create a healthy environment for the formation of the fetus.

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