CLINICAL EFFICACY AND SAFETY OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA AGONISTS IN RHEUMATOID ARTHRITIS: AN OPEN-LABEL CONTROLLED STUDY
https://doi.org/10.15789/1563-0625-2014-1-71-80
Abstract
Efficacy and pharmacodynamics of PPARα agonist fenofibrate have been assessed in a controlled study on patients with active rheumatoid arthritis (RA) receiving traditional DMARDs. After 12 weeks of treatment, we observed a significant drop of DAS28 scores, decrease in number of tender and swollen joints, and slower ESR in fenofibrate group (n = 33) as compared with control group (n = 17). Frequency of EULAR and ACR20 responses was 4 times higher in fenofibrate group. Clinical effect was accompanied by decrease in serum immunological markers of atherosclerosis (IL-6 and CRP), diminished total cholesterol and
triglycerides. In summary, PPARα agonists may represent an example of a “hub” treatment for rheumatoid arthritis, with pleiotropic effects directed at inflammatory activity and increased risk of other comorbidites, including atherosclerosis.
About the Authors
V. S. Shirinsky
Research Institute of Clinical Immunology, Russian Academy of Medical Sciences, Siberian Branch, Novosibirsk
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, Chief, Laboratory of Clinical Immunopharmacology
O. A. Polovnikova
Research Institute of Clinical Immunology, Russian Academy of Medical Sciences, Siberian Branch, Novosibirsk
Russian Federation
Russian Federation
Research Associate, Laboratory of Clinical Immunopharmacology
N. Yu. Kalinovskaya
Research Institute of Clinical Immunology, Russian Academy of Medical Sciences, Siberian Branch, Novosibirsk
Russian Federation
Russian Federation
PhD (Medicine), Senior Researcher, Laboratory of Clinical Immunopharmacology
I. V. Shirinsky
Research Institute of Clinical Immunology, Russian Academy of Medical Sciences, Siberian Branch, Novosibirsk
Russian Federation
PhD, MD (Medicine), Senior Researcher Fellow, Laboratory of Clinical Immunopharmacology
Russian Federation
PhD, MD (Medicine), Senior Researcher Fellow, Laboratory of Clinical Immunopharmacology
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For citations:
Shirinsky V.S., Polovnikova O.A., Kalinovskaya N.Yu., Shirinsky I.V. CLINICAL EFFICACY AND SAFETY OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA AGONISTS IN RHEUMATOID ARTHRITIS: AN OPEN-LABEL CONTROLLED STUDY. Medical Immunology (Russia). 2014;16(1):71-80. (In Russ.) https://doi.org/10.15789/1563-0625-2014-1-71-80
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