CONTENTS OF ANGIOGENIC GROWTH FACTORS IN THE PATIENTS WITH LOCAL FROSTBITES
https://doi.org/10.15789/1563-0625-2008-4-5-483-485
Abstract
Abstract. The aim was to study the contents TGFα, TGFβ1 and VEGF in blood of patients with local frostbites. 50 men with local frostbites of extremities (II-IV degree) in the age up to 17-45 years old were examined. The patients were classified depending on the time elapsing post-lesion (group 1, early reactive period; group 2, late reactive period; group 3, granulation and epithelization of lesions). Quantitative determination of TGFα, TGFβ1 and VEGF in blood was performed by ELISA techniques. Blood samples were taken at early, late reactive periods and at period of epithelization of local frostbites. It was revealed that the contents of TGFα, TGFβ1 and VEGF were increased in patients’ blood at later terms after local frostbites. VEGF contents in blood of the frostbite patients increased to higher degrees than the values of TGFα and TGFβ1. An imbalance between TGFα, TGFβ1 and VEGF contents in frostbites was observed in cases of lagging repair and unfavorable clinical course. (Med. Immunol., vol. 10, N 4-5, pp 483-485).
About the Authors
K. G. Shapovalov
ГОУ ВПО Читинская Государственная медицинская академия Росздрава
Russian Federation
Russian Federation
V. A. Sizonenko
ГОУ ВПО Читинская Государственная медицинская академия Росздрава
Russian Federation
Russian Federation
Yu. A. Vitkovsky
ГОУ ВПО Читинская Государственная медицинская академия Росздрава
Russian Federation
Russian Federation
References
1. Вихриев Б.С., Кичемасов С.Х., Скворцов Ю.Р. Местные поражения холодом – Л.: Медицина, 1991. – 192 с.
2. Котельников В.П. Отморожения – М.: Медицина, 1988. – 256 с.
3. Кузник Б.И. Физиология и патология системы крови. – Чита, 2004. – С. 155-181.
4. Сизоненко В.А. Классификация холодовой травмы // Третья конференция по проблеме «Холодовая травма». – СПб., 2002. – С. 202-208.
5. Симбирцев А.С. Роль цитокинов в регуляции физиологических функций иммунной системы // Физиология и патология иммунной системы. – 2004. – № 10. – С. 3-9.
6. Фрейдлин И.С. Иммунная система и ее дефекты – СПб.: НТФФ «Полисан». – 1998. – 112 с.
7. Хаитов Р.М., Игнатьева Г.А., Сидоро вич И.Г. Иммунология. – М.: Медицина, 2000. – С. 177-202.
8. Дисфункция эндотелия / Под ред. проф. Н.Н. Петрищева. – СПб., 2003. – 184 с.
9. Browder T., Folkman J., Pirie-Shepherd S. The hemostatic system as a regularor of angiogenesis // J. Biol. Chem. – 2000. – Vol. 275. – P. 1521-1524.
10. Liekens S., De Clerco E., Neyts E. Angiogenesis: regulators and clinical applications // Biochem. Pharmacol. – 2001. – Vol. 61. – P. 253-270.
11. Whitby D. Growth factors and wound healing // The IXth Congress of the European Burn Association. – Verona, 1995. – P. 140.
Review
For citations:
Shapovalov K.G., Sizonenko V.A., Vitkovsky Yu.A. CONTENTS OF ANGIOGENIC GROWTH FACTORS IN THE PATIENTS WITH LOCAL FROSTBITES. Medical Immunology (Russia). 2008;10(4-5):483-485. (In Russ.) https://doi.org/10.15789/1563-0625-2008-4-5-483-485
Views:
662
Email this article 