SPECIFIC STAGE-DEPENDENT FEATURES OF CYTOKINE CASCADE IN THE PATIENTS WITH BRONCHIAL ASTHMA
https://doi.org/10.15789/1563-0625-2007-4-5-493-498
Abstract
Abstract. A study of leukocyte regulation system in patients with exacerbated bronchial asthma (BA) was performed by means of measuring spontaneous and induced production of certain cytokines (IL-4, IL-1b, IL-10 and IFNg) in whole blood, and drawing some specific coefficients reflecting production of the cytokines, as compared to control values. Group 1 consisted of mixed-type BA patients, with mild clinical manifestations at exacerbation stage. A control group included twelve healthy persons. The cytokine network was evaluated according to spontaneous production of cytokines (IL-4, IL-1b, IL-10 and IFNg), or their induction with standard mitogens (PHA and E. coli LPS). The results obtained have shown that in BA as a clinical model of chronic inflammation, synthesis and activation of the cytokines depend on the phase of disease. At stage of exacerbation, an imbalance occurs between pro- and anti-inflammatory cytokines, with predominance of anti-inflammatory IL-10, which is targeted to suppression of bronchial inflammation.
About the Authors
L. V. Ryabova
НИИ иммунологии Челябинской медицинской академии, г. Челябинск
Russian Federation
Russian Federation
A. V. Zurochka
НИИ иммунологии Челябинской медицинской академии, г. Челябинск
Russian Federation
Russian Federation
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Review
For citations:
Ryabova L.V., Zurochka A.V. SPECIFIC STAGE-DEPENDENT FEATURES OF CYTOKINE CASCADE IN THE PATIENTS WITH BRONCHIAL ASTHMA. Medical Immunology (Russia). 2007;9(4-5):493-498. (In Russ.) https://doi.org/10.15789/1563-0625-2007-4-5-493-498
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