IgM AUTOANTIBODIES TO DNA IN BLOOD SERUM OF THE PATIENTS WITH HEMORRHAGIC FEVER WITH RENAL SYNDROME
https://doi.org/10.15789/1563-0625-2010-4-5-375-380
Abstract
Levels of IgM autoantibodies (AAbs) to native (double-stranded) and denaturated (single-stranded) DNA were studied in blood serum of sixty patients with hemorrhagic fever with renal syndrome (HFRS) and twenty-five healthy persons, using an ELISA technique. The median levels of IgM AAbs to double-stranded DNA in blood serum of healthy persons and HFRS patients corresponded to 0.41 and 0.53 arbitrary units, respectively. Thus, the difference between the samples from HFRS and healthy persons proved to be non-significant. The median level of IgM AAbs to single-stranded DNA in blood sera of HFRS patients (0.71 arbitrary units) did significantly exceed serum values of healthy persons (0.57 arbitrary units). A probable involvement of IgM AAbs into regulation of IgG AAbs' production during virus-induced activation of autoimmune events in HFRS patients is discussed.
About the Authors
D. G. Ishmukhametova
Кафедра биохимии, Казанский государственный университет, г. Казань
Russian Federation
Russian Federation
B. K. Temesgen
College of Medicine and Health Sciences, Hawassa University, Ethiopia
Russian Federation
Russian Federation
O. V. Yakusheva
Учреждение Российской Академии наук Казанский институт биохимии и биофизики Казанского научного центра РАН, г. Казань
Russian Federation
Russian Federation
References
1. Гармашова Н.В., Казанский В.Е., Тышкевич О.Б., Доронин Б.М., Бунева В.Н., Невинский Г.А. Антитела к ДНК в крови больных клещевым энцефалитом//Молекулярная биология. -2004. -Т.29. -С. 723-730.
2. Гланц С. Медико-биологическая статистика. -М.: Практика, 1999. -459 с.
3. Ишмухаметова Д.Г., Темесген Б.К., Власова О.В., Бабушкина Ф.А. Аутоантитела к ДНК в сыворотке крови больных геморрагической лихорадкой с почечным синдромом//Медицинская иммунология. -2006. -Т. 8., № 5-6. -С. 653-658.
4. Лакин Г.Ф. Биометрия. -М.: Высшая школа, 1990. -352 с.
5. Рязанова Г.А., Коксин В.П., Хамзина Р.В. Свободные и связанные антитела к структурным белкам ВИЧ-1 в ранний период заболевания//Медицинская иммунология. -2005. -Т. 7, № 1. -С. 73-76.
6. Саттарова Л.И., Гафиятуллина Л.А., Аглиуллина Д.Г. Оптимизация иммуноферментной тест-системы для определения антител к ДНК//Биотехнология. -1994. -Т. 11, № 12. -С. 38-41.
7. Сомова-Исачкова Л.М., Плехова Н.Г. Патоморфогенез геморрагической лихорадки с почечным синдромом: от прошлого к будущему//Хантавирусы и хантавирусные инфекции. -Владивосток: ОАО «Примполиграфкомбинат», -2003. -С. 182-200.
8. Baumgarth N., Herman O.C., Jager G.C., Brown L.E., Herzenberg L.A., Chen J. B-1 and B-2 cell-derived immunoglobulin M antibodies are nonredundant components of the protective response to influenza virus infection//J. Exp. Med. -2000. -Vol. 192. -P. 271-280.
9. Boes M. Role of natural and immune IgM antibodies in immune responses//Mol. Immunol. -2000. -Vol. 37. -Р. 1141-1149.
10. Boes M., Schmidt T., Linkemann K., Beaudette B.C., Marshak-Rothstein A., Chen J. Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM//Proc. Natl. Acad. Sci. USA. -2000. -Vol. 97. -P. 1184-1189.
11. Clifford B.D., Donahue D., Smith L., Cable E., Luttig B., Manns M., Bonkovsky H.L. High prevalence of serological markers of autoimmunity in patients with chronic hepatitis C//Hepatology. -1995. -Vol. 21. -P. 613-619.
12. Ehrenstein M.R., Cook H.T., Neuberger M.S. Deficiency in serum immunoglobulin (Ig) M predisposes to development of IgG autoantibodies//J. Exp. Med. -2000. -Vol. 191. -P. 1253-1258.
13. Li Q.Z., Zhou J., Wandstrat A.E., Carr-Johnson F., Branch V., Karp D.R., Mohan C., Wakeland E.K., Olsen N.J. Protein array autoantibody profiles for insights into systemic lupus erythematosus and incomplete lupus syndromes//Clin. Exp. Immunol. -2007. -Vol. 147. -P. 60-70.
14. Limaye N., Mohan C. Patogenecity of anti-DNA and glomelural autoantibodies: weighing the evidence//Drug Discovery Today: Disease Models. -2004. -Vol. 1. -Р. 395-403.
15. Lin C.F., Lei H.Y., Shiau A.L., Liu C.C., Liu H.S., Yeh T.M., Chen S.H., Lin Y.S. Antibodies from dengue patient sera cross-react with endothelial cells and induce damage//J. Med. Virol. -2003. -Vol. 69. -P. 82-90.
16. Pawlotsky J., Yahia M., Andre C., Voisin M.C., Intrator L., Roudot-Thoraval F., Deforges L., Duvoux C., Zafrani E.S., Duval J., Dhumeaux D. Immunologic disorders in C virus chronic active hepatitis: а prospective case-control study//Hematology. -1994. -Vol. 19. -Р. 841-848.
17. Peng Y.F., Kowalewski R., Kim S.J., Elkon K.B. The role of IgM antibodies in the recognition and clearance of apoptotic cells//Mol. Immunol. -2005. -Vol. 42. -P. 781-787.
18. Shaw P.X., Horkko S., Chang M.K., Curtiss L.K., Palinski W., Silverman G.J., Witztum J.L. Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity//J. Clin. Invest. -2000. -Vol. 105. -P. 1731-1740.
19. Silverman G.J., Srikrishnan R., Germar K., Goodyear C.S., Andrews K.A., Ginzler E.M., Tsao B.P. Genetic imprinting of autoantibody repertoires in systemic lupus erythematosys patients//Clin. Exp. Immunol. -2008. -Vol. 153. -P. 102-116.
20. Werwitzke S., Trick D., Kamino K., Matthias T., Kniesch K., Schlegelberger B., Schmidt R.E., Witte T. Inhibition of lupus disease by anti-double-stranded DNA antibodies of the IgM isotype in the (NZB × NZW) F1 mouse//Arthritis Rheum. 1891. -2005. -Vol. 52. -P. 3629-3638.
21. Zandman-Goddard G., Shoenfeld Y. HIV and autoimmunity//Autoimmunity Reviews. -2002. -Vol.1. -Р. 329-337.
Review
For citations:
Ishmukhametova D.G., Temesgen B.K., Yakusheva O.V. IgM AUTOANTIBODIES TO DNA IN BLOOD SERUM OF THE PATIENTS WITH HEMORRHAGIC FEVER WITH RENAL SYNDROME. Medical Immunology (Russia). 2010;12(4-5):375-380. (In Russ.) https://doi.org/10.15789/1563-0625-2010-4-5-375-380
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