<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">mimmun</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинская иммунология</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Immunology (Russia)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1563-0625</issn><issn pub-type="epub">2313-741X</issn><publisher><publisher-name>SPb RAACI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15789/1563-0625-2010-4-5-375-380</article-id><article-id custom-type="elpub" pub-id-type="custom">mimmun-204</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>IgM АУТОАНТИТЕЛА К ДНК В СЫВОРОТКЕ КРОВИ БОЛЬНЫХ ГЕМОРРАГИЧЕСКОЙ ЛИХОРАДКОЙ С ПОЧЕЧНЫМ СИНДРОМОМ</article-title><trans-title-group xml:lang="en"><trans-title>IgM AUTOANTIBODIES TO DNA IN BLOOD SERUM OF THE PATIENTS WITH HEMORRHAGIC  FEVER WITH RENAL SYNDROME</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ишмухаметова</surname><given-names>Д. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Ishmukhametova</surname><given-names>D. G.</given-names></name></name-alternatives><email xlink:type="simple">dilgal@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Темесген</surname><given-names>Б. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Temesgen</surname><given-names>B. K.</given-names></name></name-alternatives><email xlink:type="simple">dilgal@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Якушева</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Yakusheva</surname><given-names>O. V.</given-names></name></name-alternatives><email xlink:type="simple">dilgal@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Кафедра биохимии, Казанский государственный университет, г. Казань</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-2"><institution>College of Medicine and Health Sciences, Hawassa University, Ethiopia</institution><country>Russian Federation</country></aff><aff xml:lang="ru" id="aff-3"><institution>Учреждение Российской Академии наук Казанский институт биохимии и биофизики Казанского научного центра РАН, г. Казань</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>17</day><month>07</month><year>2014</year></pub-date><volume>12</volume><issue>4-5</issue><fpage>375</fpage><lpage>380</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ишмухаметова Д.Г., Темесген Б.К., Якушева О.В., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Ишмухаметова Д.Г., Темесген Б.К., Якушева О.В.</copyright-holder><copyright-holder xml:lang="en">Ishmukhametova D.G., Temesgen B.K., Yakusheva O.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.mimmun.ru/mimmun/article/view/204">https://www.mimmun.ru/mimmun/article/view/204</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>аутоиммунитет</kwd><kwd>IgM аутоантитела к ДНК</kwd><kwd>геморрагическая лихорадка</kwd><kwd>почечный синдром</kwd></kwd-group><kwd-group xml:lang="en"><kwd>autoimmunity</kwd><kwd>anti-DNA IgM autoantibodies</kwd><kwd>hemorrhagic fever</kwd><kwd>renal syndrome</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Гармашова Н.В., Казанский В.Е., Тышкевич О.Б., Доронин Б.М., Бунева В.Н., Невинский Г.А. Антитела к ДНК в крови больных клещевым энцефалитом//Молекулярная биология. -2004. -Т.29. -С. 723-730.</mixed-citation><mixed-citation xml:lang="en">Гармашова Н.В., Казанский В.Е., Тышкевич О.Б., Доронин Б.М., Бунева В.Н., Невинский Г.А. Антитела к ДНК в крови больных клещевым энцефалитом//Молекулярная биология. -2004. -Т.29. -С. 723-730.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Гланц С. Медико-биологическая статистика. -М.: Практика, 1999. -459 с.</mixed-citation><mixed-citation xml:lang="en">Гланц С. Медико-биологическая статистика. -М.: Практика, 1999. -459 с.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ишмухаметова Д.Г., Темесген Б.К., Власова О.В., Бабушкина Ф.А. Аутоантитела к ДНК в сыворотке крови больных геморрагической лихорадкой с почечным синдромом//Медицинская иммунология. -2006. -Т. 8., № 5-6. -С. 653-658.</mixed-citation><mixed-citation xml:lang="en">Ишмухаметова Д.Г., Темесген Б.К., Власова О.В., Бабушкина Ф.А. Аутоантитела к ДНК в сыворотке крови больных геморрагической лихорадкой с почечным синдромом//Медицинская иммунология. -2006. -Т. 8., № 5-6. -С. 653-658.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Лакин Г.Ф. Биометрия. -М.: Высшая школа, 1990. -352 с.</mixed-citation><mixed-citation xml:lang="en">Лакин Г.Ф. Биометрия. -М.: Высшая школа, 1990. -352 с.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Рязанова Г.А., Коксин В.П., Хамзина Р.В. Свободные и связанные антитела к структурным белкам ВИЧ-1 в ранний период заболевания//Медицинская иммунология. -2005. -Т. 7, № 1. -С. 73-76.</mixed-citation><mixed-citation xml:lang="en">Рязанова Г.А., Коксин В.П., Хамзина Р.В. Свободные и связанные антитела к структурным белкам ВИЧ-1 в ранний период заболевания//Медицинская иммунология. -2005. -Т. 7, № 1. -С. 73-76.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Саттарова Л.И., Гафиятуллина Л.А., Аглиуллина Д.Г. Оптимизация иммуноферментной тест-системы для определения антител к ДНК//Биотехнология. -1994. -Т. 11, № 12. -С. 38-41.</mixed-citation><mixed-citation xml:lang="en">Саттарова Л.И., Гафиятуллина Л.А., Аглиуллина Д.Г. Оптимизация иммуноферментной тест-системы для определения антител к ДНК//Биотехнология. -1994. -Т. 11, № 12. -С. 38-41.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Сомова-Исачкова Л.М., Плехова Н.Г. Патоморфогенез геморрагической лихорадки с почечным синдромом: от прошлого к будущему//Хантавирусы и хантавирусные инфекции. -Владивосток: ОАО «Примполиграфкомбинат», -2003. -С. 182-200.</mixed-citation><mixed-citation xml:lang="en">Сомова-Исачкова Л.М., Плехова Н.Г. Патоморфогенез геморрагической лихорадки с почечным синдромом: от прошлого к будущему//Хантавирусы и хантавирусные инфекции. -Владивосток: ОАО «Примполиграфкомбинат», -2003. -С. 182-200.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Baumgarth N., Herman O.C., Jager G.C., Brown L.E., Herzenberg L.A., Chen J. B-1 and B-2 cell-derived immunoglobulin M antibodies are nonredundant components of the protective response to influenza virus infection//J. Exp. Med. -2000. -Vol. 192. -P. 271-280.</mixed-citation><mixed-citation xml:lang="en">Baumgarth N., Herman O.C., Jager G.C., Brown L.E., Herzenberg L.A., Chen J. B-1 and B-2 cell-derived immunoglobulin M antibodies are nonredundant components of the protective response to influenza virus infection//J. Exp. Med. -2000. -Vol. 192. -P. 271-280.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Boes M. Role of natural and immune IgM antibodies in immune responses//Mol. Immunol. -2000. -Vol. 37. -Р. 1141-1149.</mixed-citation><mixed-citation xml:lang="en">Boes M. Role of natural and immune IgM antibodies in immune responses//Mol. Immunol. -2000. -Vol. 37. -Р. 1141-1149.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Boes M., Schmidt T., Linkemann K., Beaudette B.C., Marshak-Rothstein A., Chen J. Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM//Proc. Natl. Acad. Sci. USA. -2000. -Vol. 97. -P. 1184-1189.</mixed-citation><mixed-citation xml:lang="en">Boes M., Schmidt T., Linkemann K., Beaudette B.C., Marshak-Rothstein A., Chen J. Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM//Proc. Natl. Acad. Sci. USA. -2000. -Vol. 97. -P. 1184-1189.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Clifford B.D., Donahue D., Smith L., Cable E., Luttig B., Manns M., Bonkovsky H.L. High prevalence of serological markers of autoimmunity in patients with chronic hepatitis C//Hepatology. -1995. -Vol. 21. -P. 613-619.</mixed-citation><mixed-citation xml:lang="en">Clifford B.D., Donahue D., Smith L., Cable E., Luttig B., Manns M., Bonkovsky H.L. High prevalence of serological markers of autoimmunity in patients with chronic hepatitis C//Hepatology. -1995. -Vol. 21. -P. 613-619.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Ehrenstein M.R., Cook H.T., Neuberger M.S. Deficiency in serum immunoglobulin (Ig) M predisposes to development of IgG autoantibodies//J. Exp. Med. -2000. -Vol. 191. -P. 1253-1258.</mixed-citation><mixed-citation xml:lang="en">Ehrenstein M.R., Cook H.T., Neuberger M.S. Deficiency in serum immunoglobulin (Ig) M predisposes to development of IgG autoantibodies//J. Exp. Med. -2000. -Vol. 191. -P. 1253-1258.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Li Q.Z., Zhou J., Wandstrat A.E., Carr-Johnson F., Branch V., Karp D.R., Mohan C., Wakeland E.K., Olsen N.J. Protein array autoantibody profiles for insights into systemic lupus erythematosus and incomplete lupus syndromes//Clin. Exp. Immunol. -2007. -Vol. 147. -P. 60-70.</mixed-citation><mixed-citation xml:lang="en">Li Q.Z., Zhou J., Wandstrat A.E., Carr-Johnson F., Branch V., Karp D.R., Mohan C., Wakeland E.K., Olsen N.J. Protein array autoantibody profiles for insights into systemic lupus erythematosus and incomplete lupus syndromes//Clin. Exp. Immunol. -2007. -Vol. 147. -P. 60-70.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Limaye N., Mohan C. Patogenecity of anti-DNA and glomelural autoantibodies: weighing the evidence//Drug Discovery Today: Disease Models. -2004. -Vol. 1. -Р. 395-403.</mixed-citation><mixed-citation xml:lang="en">Limaye N., Mohan C. Patogenecity of anti-DNA and glomelural autoantibodies: weighing the evidence//Drug Discovery Today: Disease Models. -2004. -Vol. 1. -Р. 395-403.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Lin C.F., Lei H.Y., Shiau A.L., Liu C.C., Liu H.S., Yeh T.M., Chen S.H., Lin Y.S. Antibodies from dengue patient sera cross-react with endothelial cells and induce damage//J. Med. Virol. -2003. -Vol. 69. -P. 82-90.</mixed-citation><mixed-citation xml:lang="en">Lin C.F., Lei H.Y., Shiau A.L., Liu C.C., Liu H.S., Yeh T.M., Chen S.H., Lin Y.S. Antibodies from dengue patient sera cross-react with endothelial cells and induce damage//J. Med. Virol. -2003. -Vol. 69. -P. 82-90.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Pawlotsky J., Yahia M., Andre C., Voisin M.C., Intrator L., Roudot-Thoraval F., Deforges L., Duvoux C., Zafrani E.S., Duval J., Dhumeaux D. Immunologic disorders in C virus chronic active hepatitis: а prospective case-control study//Hematology. -1994. -Vol. 19. -Р. 841-848.</mixed-citation><mixed-citation xml:lang="en">Pawlotsky J., Yahia M., Andre C., Voisin M.C., Intrator L., Roudot-Thoraval F., Deforges L., Duvoux C., Zafrani E.S., Duval J., Dhumeaux D. Immunologic disorders in C virus chronic active hepatitis: а prospective case-control study//Hematology. -1994. -Vol. 19. -Р. 841-848.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Peng Y.F., Kowalewski R., Kim S.J., Elkon K.B. The role of IgM antibodies in the recognition and clearance of apoptotic cells//Mol. Immunol. -2005. -Vol. 42. -P. 781-787.</mixed-citation><mixed-citation xml:lang="en">Peng Y.F., Kowalewski R., Kim S.J., Elkon K.B. The role of IgM antibodies in the recognition and clearance of apoptotic cells//Mol. Immunol. -2005. -Vol. 42. -P. 781-787.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Shaw P.X., Horkko S., Chang M.K., Curtiss L.K., Palinski W., Silverman G.J., Witztum J.L. Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity//J. Clin. Invest. -2000. -Vol. 105. -P. 1731-1740.</mixed-citation><mixed-citation xml:lang="en">Shaw P.X., Horkko S., Chang M.K., Curtiss L.K., Palinski W., Silverman G.J., Witztum J.L. Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity//J. Clin. Invest. -2000. -Vol. 105. -P. 1731-1740.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Silverman G.J., Srikrishnan R., Germar K., Goodyear C.S., Andrews K.A., Ginzler E.M., Tsao B.P. Genetic imprinting of autoantibody repertoires in systemic lupus erythematosys patients//Clin. Exp. Immunol. -2008. -Vol. 153. -P. 102-116.</mixed-citation><mixed-citation xml:lang="en">Silverman G.J., Srikrishnan R., Germar K., Goodyear C.S., Andrews K.A., Ginzler E.M., Tsao B.P. Genetic imprinting of autoantibody repertoires in systemic lupus erythematosys patients//Clin. Exp. Immunol. -2008. -Vol. 153. -P. 102-116.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Werwitzke S., Trick D., Kamino K., Matthias T., Kniesch K., Schlegelberger B., Schmidt R.E., Witte T. Inhibition of lupus disease by anti-double-stranded DNA antibodies of the IgM isotype in the (NZB × NZW) F1 mouse//Arthritis Rheum. 1891. -2005. -Vol. 52. -P. 3629-3638.</mixed-citation><mixed-citation xml:lang="en">Werwitzke S., Trick D., Kamino K., Matthias T., Kniesch K., Schlegelberger B., Schmidt R.E., Witte T. Inhibition of lupus disease by anti-double-stranded DNA antibodies of the IgM isotype in the (NZB × NZW) F1 mouse//Arthritis Rheum. 1891. -2005. -Vol. 52. -P. 3629-3638.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Zandman-Goddard G., Shoenfeld Y. HIV and autoimmunity//Autoimmunity Reviews. -2002. -Vol.1. -Р. 329-337.</mixed-citation><mixed-citation xml:lang="en">Zandman-Goddard G., Shoenfeld Y. HIV and autoimmunity//Autoimmunity Reviews. -2002. -Vol.1. -Р. 329-337.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
