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Медицинская иммунология

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ОСНОВНЫЕ ПОВЕРХНОСТНЫЕ МАРКЕРЫ ФУНКЦИОНАЛЬНОЙ АКТИВНОСТИ Т-ЛИМФОЦИТОВ

https://doi.org/10.15789/1563-0625-2014-1-7-26

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Аннотация

В настоящем обзоре предпринята попытка систематизировать существующие представления о наиболее значимых поверхностных антигенах иммунокомпетентных клеток и оценить их роль в процессах клеточного гомеостаза и формировании патологии.

Об авторах

Л. С. Литвинова
Балтийский федеральный университет имени И. Канта, г. Калининград
Россия

д.м.н., профессор, заведующая
лабораторией иммунологии
и клеточных биотехнологий
Инновационного парка



А. А. Гуцол
Балтийский федеральный университет имени И. Канта, г. Калининград
Россия

аспирант, младший научный сотрудник
лаборатории иммунологии и клеточных биотехнологий
Инновационного парка БФУ им. И. Канта



Н. А. Сохоневич
Балтийский федеральный университет имени И. Канта, г. Калининград
Россия

аспирант, младший научный сотрудник
лаборатории иммунологии и клеточных биотехнологий
Инновационного парка БФУ им. И. Канта



К. А. Кофанова
Балтийский федеральный университет имени И. Канта, г. Калининград
Россия

аспирант, лаборатория иммунологии
и клеточных биотехнологий Инновационного парка БФУ
им. И. Канта



О. Г. Хазиахматова
Балтийский федеральный университет имени И. Канта, г. Калининград
Россия

биолог, аспирант, лаборатория
иммунологии и клеточных биотехнологий Инновационного парка
БФУ им. И. Канта



В. В. Шуплецова
Балтийский федеральный университет имени И. Канта, г. Калининград
Россия

научный сотрудник лаборатории иммунологии
и клеточных биотехнологий Инновационного парка БФУ
им. И. Канта



Е. В. Кайгородова
Балтийский федеральный университет имени И. Канта, г. Калининград
Россия

старший научный сотрудник лаборатории
иммунологии и клеточных биотехнологий Инновационного парка
БФУ им. И. Канта



А. Г. Гончаров
Балтийский федеральный университет имени И. Канта, г. Калининград
Россия

к.м.н., доцент, кафедра молекулярной
физиологии и биофизики химико-биологического института
БФУ им. И. Канта



Список литературы

1. Антонеева И.И., Петров С.Б. Маркеры апоптоза и пролиферации опухолевых клеток в динамике прогрессирования рака яичника // Онкология. – 2008. – Т. 10, № 2. – С. 234-237. Antoneeva I.I., Petrov S.B. Markery apoptoza i proliferatsii opukholevykh kletok v dinamike progressirovaniya raka yaichnika [Markers of apoptosis and proliferation of tumor cells in the dynamics of ovarian cancer progression]. Onkologiya – Oncology, 2008, vol. 10, no. 2, pp. 234-237

2. Артамонова Е. В., Тупицин Н. Н., Летягин В. П. Рецептор трансферрина (CD71) на клетках рака молочной железы // Молекулярная медицина. – 2007. – № 1. – С. 16-20. Artamonova E.V., Tupitsin N.N., Letyagin V. P. Retseptor transferrina (CD71) na kletkakh raka molochnoy zhelezy [Transferrin Receptor (CD71) on breast cancer cell]. Molekulyarnaya meditsina – Molecular Medicine, 2007, no. 1, pp. 16-20.

3. Барышников А.Ю., Шишкин Ю.В. Иммунологические проблемы апоптоза. – М.: Эдиториа, 2002. – 320 с. Baryshnikov A.Yu., Shishkin Yu.V. Immunologicheskie problemy apoptoza [Immunological problems apoptosis]. Мoscow, Editoria, 2002. 320 p

4. Жукова О.Б., Рязанцева Н.В., Новицкий В.В. Апоптоз и вирусная инфекция. – Томск: Изд-во Томского ун-та, 2006. – 142 с. Zhukova O.B., Ryazantseva N.V., Novitskiy V.V. Apoptoz i virusnaya infektsiya [Apoptosis and viralinfection]. Tomsk, Tomsk University Press, 2006. 142 p.

5. Зенин В.В., Аксенов Н.Д., Митюшова Е.В., Марахова И.И. Поверхностная экспрессия CD25 у лимфоцитов человека на разных стадиях запуска пролиферативного ответа. I. Роль тирозинкиназ семейств JAK и Src по данным ингибиторного анализа // Цитология. – 2011. – T. 53, № 8. – С. 645-651. Zenin V.V., Aksenov N.D., Mityushova E.V., Marakhova I.I. Poverkhnostnaya ekspressiya CD25 ulimfotsitov cheloveka na raznykh stadiyakh zapuska proliferativnogo otveta. I. Rol` tirozinkinaz semeystv JAK i Src po dannym ingibitornogo analiza [The surface expression of C25 at different stages of proliferative response in human lymphocytes. I. The role of JAK and SRC tyrosine kinases as revealed by inhibitory analysis]. Tsitologiya – Cytology, 2011, vol. 53, no. 8, pp. 645-651.

6. Кайгородова Е.В., Рязанцева Н.В., Новицкий В.В. Белки теплового шока и митогенактивированные протеинкиназы JNK, р38: роль в адаптации и дизрегуляции клетки при стресс-индуцированном апоптозе // Молекулярная медицина. – 2012. – № 1. – С. 3-11. Kaygorodova E.V., Ryazantseva N.V., Novitskiy V.V. Belki teplovogo shoka i mitogenaktivirovannye proteinkinazy JNK, r38: rol` v adaptatsii i dizregulyatsii kletki pri stress-indutsirovannom apoptoze [Heat shock proteins and mitogen-activated protein kinase JNK and P38: the role in adaptation and regulation of molecular mechanisms of stress-induced cell apoptosis]. Molekulyarnaya meditsina – Molecular Medicine, 2012, no. 1, pp. 3-11.

7. Литвинова Л.С., Кириенкова Е.В., Аксенова Н.Н., Затолокин П.А., Газатова Н.Д. Особенности клеточного иммунитета и цитокинового репертуара у пациентов с метаболическим синдромом // Бюллетень СибГМУ. – 2012. – № 3. – С. 53-58. Litvinova L.S., Kirienkova E.V., Aksenova N.N., Zatolokin P.A., Gazatova N.D. Osobennosti kletochnogoimmuniteta i tsitokinovogo repertuara u patsientov s metabolicheskim sindromom [Features of cellular immunity and cytokine repertoire in patients with metabolic syndrome]. Byulleten` SibGMU – Bulletin of Siberian Medicine, 2012, no. 3, pp. 53-58.

8. Луговская С.А., Почтарь М.Е., Тупицин Н.Н. Иммунофенотипирование в диагностике гемобластозов. – М., Тверь: Триада, 2005. – 166 с. Lugovskaya S.A., Pochtar` M.E., Tupitsin N.N. Immunofenotipirovanie v diagnostike gemoblastozov [Immunophenotyping in the diagnosis of hematological malignancies]. Moscow, Triada, 2005. 166 p.

9. Москалева Е.Ю., Северин С.Е. Возможные механизмы адаптации клетки к повреждениям, индуцирующим программированную гибель. Связь с патологией // Патологическая физиология и экспериментальная терапия. – 2006. – № 2. – С. 2-14. Moskaleva E.Yu., Severin S.E. Vozmozhnye mekhanizmy adaptatsii kletki k povrezhdeniyam, indutsiruyushchim programmirovannuyu gibel`. Svyaz` s patologiey [Potential mechanisms of cellular damage inducing preset cell loss. Association with pathology]. Patologicheskaya fiziologiya i eksperimental`naya terapiya –Pathological Physiology and Experimental Therapy, 2006, no. 2, pp. 2-14

10. Олейник Е.К. Олейник В.М., Шибаев М.И. Маркеры активации лимфоцитов крови (CD25, CD71,CD95 и HLA-DR) у онкологических больных // Гематология и трансфузиология. – 2006. – Т. 51, № 1. –С. 18-22. Oleynik E. K. Oleynik V. M., Shibaev M. I. Markery aktivatsii limfotsitov krovi (CD25, CD71, CD95 i HLA-DR) u onkologicheskikh bol`nykh [Markers of blood lymphocytes (CD25, CD71, CD95 and HLA-DR) activation in cancer patients]. Gematologiya i transfuziologiya – Hematology and Transfusiology, 2006, vol. 51, no. 1, pp. 18-22.

11. Петухов В.И. Роль Fas-опосредованного апоптоза в реализации противоопухолевого эффекта α-интерферона при хроническом миелолейкозе // Гематология и трансфузиология. – 2000. – Т. 45, № 4. –С. 29-33. Petukhov V.I. Rol` Fas-oposredovannogo apoptoza v realizatsii protivoopukholevogo effekta α-interferona pri khronicheskom mieloleykoze [The role of Fas-mediated apoptosis in the antitumor effect of α-interferon in chronic myeloid leukemia].Gematologiya i transfuziologiya – Hematology and Transfusiology, 2000, vol. 45, no. 4, pp. 29-33.

12. Самойлова P.C., Булычева Т.Н. Иммунофенотипическая диагностика хронических лимфопролиферативных заболеваний: опыт практической работы // Лабораторная диагностика Terra Medica. – 2005. –Т. 8, № 3. – С. 27-31. Samoylova P.C., Bulycheva T.N. Immunofenotipicheskaya diagnostika khronicheskikh limfoproliferativnykh zabolevaniy: opyt prakticheskoy raboty [Immunophenotyping diagnosis of chronic lymphoproliferative diseases: practical experience]. Laboratornaya diagnostika Terra Medica – Laboratory Diagnosis Terra Medica, 2005, vol. 8, no. 3, pp. 27-31.

13. Степанов Ю.М., Фильченков А.А., Кушлинский Н.Е. Система Fas/Fas-лиганд. – Днепропетровск: ДИА, 2000. – 48 с. Stepanov Yu.M., Fil`chenkov A.A., Kushlinskiy N.E. Sistema Fas/Fas-ligand [The system of Fas/ Fas- ligand]. Dnepropetrovsk, DIA, 2000. 48 p.

14. Тупицын Н.Н., Летягин В.П., Паниченко А.В., Васильев М.Б., Шинкарев С.А., Артамонова Е.В., Огнерубов Н.А., Ермилова В.Д., Рязанцева С.Н. Новые иммунологические маркеры (CD71, LU-BCRU-G7), взаимосвязанные с прогнозом рака молочной железы // Cовременная онкология. – 2001. – Т. 3, № 4. –С. 161-163 . Tupitsyn N.N., Letyagin V.P., Panichenko A.V., Vasilèv M.B., Shinkarev S.A., Artamonova E.V., Ognerubov N.A., Ermilova V.D., Ryazantseva S.N. Novye immunologicheskie markery (CD71, LU-BCRU-G7), vzaimosvyazannye s prognozom raka molochnoy zhelezy [New immunologic markers (CD71, LU-BCRU-G7), related to the forecast of breast cancer]. Sovremennaya onkologiya – Innovative Oncology, 2001, vol. 3. no. 4, pp. 161-163.

15. Хаитов P.M., Пинегин Б.В., Истамов Х.И. Экологическая иммунология. – М.: ВНИРО, 1995. – 57 с. Haitov P.M., Pinegin B.V., Istamov H.I. Ekologicheskaya immunologiya [Ecological immunology]. Moscow, VNIRO, 1995. 57 p.

16. Хаитов Р.М. Иммунология: учебник для студентов медицинских вузов. – М.: ГЭОТАР Медиа, 2009. – 311 с. Haitov R.M. Immunologiya: uchebnik dlya studentov meditsinskikh vuzov [Immunology: a textbook for medical students]. Moscow, GEOTAR Media, 2009. 311 p.

17. Чередеев А.Н., Горлина Н.К., Козлов И.Г. CD-маркеры в практике клинико-диагностических лабораторий // Клиническая лабораторная диагностика. – 1999. – № 6. – С. 25-31. Cheredeev A.N., Gorlina N.K., Kozlov I.G. CD-markery v praktike kliniko-diagnosticheskikh laboratoriy [CD-markers in the practice of clinical diagnostic laboratories]. Klinicheskaya laboratornaya diagnostika – Clinical Laboratory Diagnostics, 1999, no. 6, pp. 25-31.

18. Шатрова А.Н., Зенин В.В., Аксенов Н.Д., Митюшова Е.В., Марахова И.И. 2011. Поверхностная экспрессия CD25 у лимфоцитов человека на разных стадиях запуска пролиферативного ответа. II. Действие интерлейкина-2 // Цитология. – 2011. – T. 53, № 8. – С. 652-658. Shatrova A.N., Zenin V.V., Aksenov N.D., Mityushova E.V., Marakhova I.I. 2011. Poverkhnostnaya ekspressiya CD25 u limfotsitov cheloveka na raznykh stadiyakh zapuska proliferativnogo otveta. II. Deystvie interleykina-2 [The surface expression of CD25 at different stages of proliferative response in human lymphosytes II. The role of interleukin-2]. Tsitologiya – Cytology, 2011, vol. 53, no. 8, pp. 652-658.

19. Ярилин А.А. Основы иммунологии. – М.: Медицина, 1999. – 608 с. Yarilin A.A. Osnovy immunologii [Immunology]. Мoscow, Medicine, 1999. 608 p.

20. Aggarwal B.B. Signalling pathways of the TNF superfamily: a double-edged sword. Nat. Rev. Immunol., 2003, vol. 3, pp. 745-756.

21. Albon S.J., Mancao C., Gilmour K., White G., Ricciardelli I., Brewin J., Lugthart G., Wallace R., Amrolia P.J. Optimization of methodology for production of CD25/CD71 allodepleted donor T cells for clinical use. Cytotherapy, 2013, vol. 15, no. 1, pp. 109-121.

22. Andera L. Signaling activated by the death receptors of the TNFR family. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub., 2009, vol. 153, no. 3, pp. 173-180.

23. Baecher-Allan C., Brown J.A., Freeman G.J., Hafler D.A. CD4+CD25high regulatory cells in human peripheral blood. J. Immunol., 2001, vol. 167, no. 3, pp. 1245-1253.

24. Bahri R., Bollinger A., Bollinger T., Orinska Z., Bulfone-Paus S. Ectonucleotidase CD38 demarcates regulatory, memory-like CD8+ T cells with IFN-γ-mediated suppressor activities. PLoS One, 2012, vol. 7, no. 9, p. 45234.

25. Baynes R.D., Skikne B.S., Cook J.D. Circulating transferrin receptors and assessment of iron status. J. Nutr. Biochem., 1994, vol. 5, pp. 322-330.

26. Beguin Y., Huebers H.A., Josephson B., Finch C.A. Transferrin receptors in rat plasma. Proc. Natl. Acad. Sci. USA, 1988, vol. 85, no. 2. 637 p.

27. Beguin Y. The soluble transferring receptor: biological aspects and clinical usefulness as quantitative measure of erythropoiesis. Hematologica, 1992, vol. 77, no. 1, pp. 1-10.

28. Benczik M., Gaffen S.L. The interleukin (IL)-2 family cytokines: survival and proliferation signaling pathways in T lymphocytes. Immunol. Invest., 2004, vol. 33, no. 2, pp. 109-142.

29. Bertho N., Dr nou B., Laupeze B., Berre C.L., Amiot L., Grosset J.M., Fardel O., Charron D., Mooney N., Fauchet R. HLA-DR-mediated apoptosis susceptibility discriminates differentiation stages of dendritic/monocytic APC. J. Immunol., 2000, vol. 164, no. 5, pp. 2379-2385.

30. Boettler T., Panther E., Bengsch B., Nazarova N., Spangenberg H.C., Blum H.E., Thimme R. Expression of the interleukin-7 receptor alpha chain (CD127) on virus-specific CD8+ T cells identifies functionally and phenotypically defined memory T cells during acute resolving hepatitis B virus infection. J. Virol., 2006, vol. 80, no. 7, pp. 3532-3540.

31. Bromley S.K., Thomas S.Y., Luster A.D. Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics. Nat. Immunol., 2005, vol. 6, no. 9, pp. 895-901. 32. Brunner M.C., Chambers C.A., Chan F.K., Hanke J., Winoto A., Winoto A., Allison J.P. CTLA-4-Mediated inhibition of early events of T cell proliferation. J. Immunol., 1999, vol. 162, pp. 5813-5820.

32. Bui M.H., Visapaa H., Seligson D., Kim H., Han K.R., Huang Y., Horvath S., Stanbridge E.J., Palotie A., Figlin R.A., Belldegrun A.S. Prognostic value of carbonic anhydrase IX and Ki-67 as predictors of survival for renal cell carcinoma. J. Urol., 2004, vol. 171, no. 6, pp. 2461-2466.

33. Burne M.J., Elghandour A., Haq M., Saba S.R., Norman J., Condon T., Bennett F., Rabb H. IL-1 and TNF independent pathways mediate ICAM-1/VCAM-1 up-regulation in ischemia reperfusion injury. J. Leukoc. Biol., 2001, vol. 70, no. 2, pp. 192-198.

34. Campbell J.J., Murphy K.E., Kunkel E.J., Brightling C.E., Soler D., Shen Z., Boisvert J., Greenberg H.B., Vierra M.A., Goodman S.B., Genovese M.C., Wardlaw A.J., Butcher E.C., Wu L. CCR7 expression and memory T cell diversity in humans. J. Immunol., 2001, vol. 166, no. 2, pp. 877-884.

35. Carrette F., Surh C.D. IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis. Semin. Immunol., 2012, vol. 24, no. 3, pp. 209-217.

36. Carswell E.A., Old L.J., Kassel R.L., Green S., Fiore N., Williamson B. An endotoxin-induced serum factor that causes necrosis of tumors. Proc. Natl. Acad. Sci. USA, 1975, vol. 72, no. 9, pp. 3666-3670.

37. Chatila T.A. Role of regulatory T cells in human diseases. J. Allergy Clin. Immunol., 2005, vol. 116, no. 5, pp. 949-959.

38. Chuang E., Fisher T.S., Morgan R.W., Robbins M.D., Duerr J.M., Vander Heiden M.G., Gardner J.P., Hambor J.E., Neveu M.J., Thompson C.B. The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A. Immunity, 2000, vol. 13, pp. 313-322.

39. Clausen J., Vergeiner B., Enk M., Petzer A.L., Gastl G., Gunsilius E. Functional significance of the activation-associated receptor СD25 and CD69 on human NK-cells and NK-like T-cells. Immunobiology, 2003, vol. 207, no. 2, pp. 85-93.

40. Cook J.D. Skikne B.S., Baynes R.D.Serum transferrin receptor. Annu Rev. Med., 1993, vol. 44. 63 p.

41. Crawley A.M., Angel J.B. The influence of HIV on CD127 expression and its potential implications for IL-7 therapy. Semin. Immunol., 2012, vol. 24, no. 3, pp. 231-240.

42. Cserti-Gazdewich C.M., Dzik W.H., Erdman L., Ssewanyana I., Dhabangi A., Musoke C., Kain K.C. Combined measurement of soluble and cellular ICAM-1 among children with Plasmodium falciparum malaria in Uganda. Malar J., 2010, vol. 9, pp. 233-241.

43. Daleke D.L., 2003 Regulation of transbilayer plasma membrane phospholipid asymmetry. J. Lipid Res., 2003, vol. 44, no. 2, pp. 233-242.

44. D’Ambrosio D., Cantrell D.A., Frati L., Santoni A., Testi R. Involvement of p21ras in T cell CD69 expression. Eur. J. Immunol., 1994, vol. 24, p. 616.

45. De Maria R., Cifone M.G., R. Trotta R., Rippo M.R., Festuccia C., Santoni A., Testi R. Triggering of human monocyte activation through CD69, a member of the natural killer cell gene complex family of signal transducing receptors. Exp. Med., 1994, vol. 180, pp. 1999-2004.

46. Diamond M.S., Staunton D.E., de Fougerolles A.R., Stacker S.A., Garcia-Aguilar J., Hibbs M.L., Springer T.A. ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18). J. Cell Biol., 1990, vol. 111, no. 6, pp. 3129-3139.

47. Dieckmann D., Bruett C.H., Ploettner H., Lutz M.B., Schuler G. Human CD4(+)CD25(+) regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells. J. Exp. Med., 2002, vol. 196, no. 2, pp. 247-253.

48. Drappa J., Brot N., Elkon K.B. The Fas protein is expressed at high levels on CD41CD81 thymocytes and activated mature lymphocytes in normal mice but not in the lupus-prone strain, MRL lpr/lpr. Proc. Natl. Acad. Sci. USA, 1993, vol. 90, no. 21, pp. 10340-10344.

49. Dustin M.L., Rothlein R., Bhan A.K., Dinarello C.A., Springer T.A. Induction by IL-1 and interferon-γ: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J. Immunol., 2011, vol. 186, no. 9, pp. 5024-5033.

50. Egen J.G., Allison J.P. Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength. Immunity, 2002, vol. 16, pp. 23-35.

51. Eicher D.M., Damjanovich S., Waldmann T.A. Oligomerization of IL-2 Ralph. Cytokine, 2002, vol. 17, no. 2, pp. 82-90.

52. Ellery J.M., Nicholls P. J. Possible mechanism for the alpha subunit of the interleukin-2 receptor (CD25) to influence interleukin-2 receptor signal transduction. Immunol. Cell Biol., 2002, vol. 80, no. 4, pp. 351-359.

53. Eskes R., Antonsson B, Osen-Sand A., Montessuit S., Richter C., Sadoul R., Mazzei G., Nichols A., Martinou J.C. Bax-induced cytochrome C release from mitochondria is independent of the permeability transition pore but highly dependent on Mg2+ ions. J. Cell Biol., 1998, vol. 143, pp. 217-224.

54. Fas S.C., Baumann S., Krueger A., Frey C.R., Schulze-Bergkamen H., Brenner D., Stumpf C., Kappes K., Krammer P.H. In vitro generated human memory-like T cells are CD95 type II cells and resistant towards CD95-mediated apoptosis. Eur. J. Immunol., 2006, vol. 36, no. 11, pp. 2894-2903.

55. Ferrero E. The making of a leukocyte receptor: origin, genes and regulation of human CD38 and related molecules. Chem. Immunol., 2000, vol. 75, pp. 1-19.

56. Flora A., Zocchi E., Guida L., Franco L., Bruzzone S. Autocrine and paracrine calcium signaling by the CD38/NAD+/Cyclic ADP-ribose system. Ann. N.Y. Acad. Sci., 2004, vol. 1028, pp. 176-191.

57. Forster R., Davalos-Misslitz A.C., Rot A. CCR7 and its ligands: balancing immunity and tolerance. Nat. Rev. Immunol., 2008, vol. 8, no. 5, pp. 362-371.

58. Fotin-Mleczek M., Henkler F., Samel D., Reichwein M., Hausser A., Parmryd I., Scheurich P., Schmid J.A., Wajant H. Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8. Journal of Cell Science, 2002, vol. 115, no. 13, pp. 2757-2770.

59. Freeman B.E., Hammarlund E., Raué H.P., Slifka M.K. Regulation of innate CD8+T-cell activation mediated by cytokines. Proc. Natl. Acad. Sci. USA, 2012, vol. 109, no. 25, pp. 9971-9976.

60. Fuchs R., Blaas D. Productive entry pathways of human rhinoviruses. Adv. Virol., 2012, vol. 2012, p. 826301.

61. Gaffen S.L. Signaling domains of the interleukin-2 receptor. Cytokine, 2001, vol. 14, no. 2, pp. 63-77.

62. Gerosa F., Scardoni M., Tommasi M., Benati C., Snelli L., Gandini G., Libonati M., Tridente G., Carra G. Interferon alpha induces expression of the CD69 activation antigen in human resting NK cells, while interferon gamma and tumor necrosis factor alpha are ineffective. Int. J. Cancer, 1991, vol. 48, no. 3, pp. 473-475.

63. Gerosa F., Tommasi M., Scardoni M., Accolla R.S., Pozzan T., Libonati M., Tridente G., Carra G. Structural analysis of the CD69 early activation antigen by two monoclonal antibodies directed to different epitopes. Mol. Immunol., 1991, vol. 28, no. 1-2, pp. 159-168.

64. Gimsa U., Oren A., Pandiyan P., Teichmann D., Bechmann I., Nitsch R., Brunner-Weinzierl M.C. Astrocytes protect the CNS: antigen-specific T helper cell responses are inhibited by astrocyte-induced upregulation of CTLA-4 (CD152). Journal of Molecular Medicine, 2004, vol. 82, pp. 364-372.

65. Giraldo N.A., Bolanos N.I. , Cuellar A., Roa N., Cucunub Z., Rosas F., Velasco V., Puerta C.J.,Gonzalez J.M. T Lymphocytes from Chagasic Patients Are Activated but Lack Proliferative Capacity and Down-Regulate CD28 and CD3ζ. PLoS Negl. Trop. Dis., 2013, vol. 7, no. 1, p. e2038.

66. Graca L., Cobbold S.P. Identification of regulatory T cells in tolerated allografts. J. Exp. Med., 2002, vol. 195, no. 12, pp. 1641-1646.

67. Grossman W.J., Verbsky J.W., Barchet W., Colonna M., Atkinson J.P., Ley T.J. Human T-regulatory cells can use the perforin pathway to cause autologous target cell death. Immunity, 2004, vol. 21, no. 4, pp. 589-601.

68. Gupta S., Gollapudi S. CD95-mediated apoptosis in naéve, central and effector memory subsets of CD4+ and CD8+ T cells in aged humans. Exp. Gerontol., 2008, vol. 43, no. 4, pp. 266-274.

69. Hasegawa A., Nakayama T. Role of CD69 in the pathogenesis of inflammation. Nihon Rinsho Meneki Gakkai Kaishi, 2010, vol. 33, no. 4, pp. 189-195.

70. Hellemans P., van Dam P.A., Weyler J., van Oosterom A.T., Buytaert P., Van Marck E. Prognostic value of bcl-2 expression in invasive breast cancer. Br. J. Cancer, 1995, vol. 72, pp. 354-360.

71. Henrich D., Zimmer S., Seebach C., Frank J., Barker J., Marzi I. Trauma-activated polymorphonucleated leukocytes damage endothelial progenitor cells: probable role of CD11b/CD18-CD54 interaction and release of reactive oxygen species. Shock., 2011, vol. 36, no. 3, pp. 216-222.

72. Herndler-Brandstetter D., Schwaiger S., Veel E., Fehrer C., Cioca D.P., Almanzar G., Keller M., Pfister G., Parson W., W rzner R., Sch nitzer D., Henson S.M., Aspinall R., Lepperdinger G., Grubeck-Loebenstein B. CD25-expressing CD8+ T cells are potent memory cells in old age. J. Immunol., 2005, vol. 175, no. 3, pp. 1566-1574.

73. Hervier B., Beziat V., Haroche J., Mathian A., Lebon P., Ghillani-Dalbin P., Musset L., Debr P., Amoura Z., Vieillard V. Phenotype and function of natural killer cells in systemic lupus erythematosus: excess interferon-γ production in patients with active disease. Arthritis Rheum., 2011, vol. 63, no. 6, pp. 1698-16706.

74. Honn K.V., Tang D.G. Adhesion molecules and tumor cell interaction with endothelium and subendothelial matrix. Cancer Metastasis Rev., 1992, vol. 11, no. 3-4, pp. 353-375.

75. H pken U.E., Droese J., Li J.P., Joergensen J., Breitfeld D., Zerwes H.G., Lipp M. The chemokine receptor CCR7 controls lymph node-dependent cytotoxic T cell priming in alloimmune responses. Eur. J. Immunol., 2004, vol. 34, no. 2, pp. 461-470.

76. Imamichi H., Lempicki R.A., Adelsberger J.W., Hasley R.B., Rosenberg A., Roby G., Rehm C.A., Nelson A., Krishnan S., Pavlick M., Woods C.J., Baseler M.W., Lane H.C. The CD8+ HLA-DR+ T cells expanded in HIV-1 infection are qualitatively identical to those from healthy controls. Eur. J. Immunol., 2012, vol. 42, no. 10, pp. 2608-2620.

77. Janeway C.A., Travers P. Immunobiology: The immune system in health and disease. London: Current Biology Ltd., 1994, 1-28 p.

78. Jonuleit H., Schmitt E., Stassen M., Tuettenberg A., Knop J., Enk A.H. Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood. J. Exp. Med., 2001, vol. 193, no. 11, pp. 1285-1294.

79. Kaigorodova E.V., Ryazantseva N.V., Novitskii V.V., Maroshkina A.N., Belkina M.V. Effects of HSP27 Chaperone on THP-1 Tumor Cell Apoptosis. Bulletin of Experimental Biology and Medicine, 2012, vol. 154, pp. 77- 79.

80. Karim M., Bushell A.R., Wood K.J. Regulatory T cells in transplantation. Curr. Opin. Immunol., 2002, vol. 14, no. 5, pp. 584-591.

81. Kirchhoff S., Muller W.W., Li-Weber M., Krammer P.H. Up-regulation of c-FLIPshort and reduction of activation-induced cell death in CD28-co-stimulated human T cells. European Journal of Immunology, 2000, vol. 30, pp. 2765-2774.

82. Kliche S., Worbs T., Wang X., Degen J., Patzak I., Meineke B., Togni M., Moser M., Reinhold A., Kiefer F., Freund C., Forster R., Schraven B. CCR7-mediated LFA-1 functions in T cells are regulated by 2 independent ADAP/SKAP55 modules. Blood, 2012, vol. 119, no. 3, pp. 777-785.

83. Kobayashi H., Kumai T., Hayashi S., Matsuda Y., Aoki N., Sato K., Kimura S., Celis E. A naturally processed HLA-DR-bound peptide from the IL-9 receptor alpha of HTLV-1-transformed T cells serves as a T helper epitope. Cancer Immunol. Immunother., 2012, vol. 61, no. 12, pp. 2215-2225.

84. Kolar P., Knieke K., Hegel J.K., Quandt D., Burmester G.R., Hoff H., Brunner-Weinzierl M.C. CTLA-4 (CD152) controls homeostasis and suppressive capacity of regulatory T cells in mice. Arthritis Rheum, 2009, vol. 60, pp. 123-132.

85. Kolber M.A. CD38+CD8+ T-cells negatively correlate with CD4 central memory cells in virally suppressed HIV-1-infected individuals. AIDS, 2008, vol. 22, no. 15, pp. 1937-1941.

86. Krampe B., Al-Rubeai M. Cell death in mammalian cell culture: molecular mechanisms and cell line engineering strategies. Cytotechnology, 2010, vol. 62, no. 3, pp. 175-188.

87. Lee H.C. Enzymatic functions and structures of CD38 and homologs. J. Chem. Immunol., 2000, vol. 75, pp. 39-59.

88. Leonard W. J., Lin J. X. Cytokine receptor signaling pathways. J. Allergy Clin. Immunol., 2000, vol. 105, no. 5, pp. 877-888.

89. Levacher M., Tallet S., Dazza M., Dournon E., Rouveix B., Pocidalo J. T activation marker evaluation in ARC patients treated with AZT: Comparison with CD4+ lymphocyte count in non-progressors and progressors towards AIDS. Clin. Exp. Immunol., 1990, vol. 81, pp. 177-182.

90. Li L., Fang C.J., Ryan J.C., Niemi E.C., Lebron J.A., Bjorkman P.J., Arase H., Torti F.M., Torti S.V., Nakamura M.C., Seaman W.E. Binding and uptake of H-ferritin are mediated by human transferrin receptor-1. Proc. Natl. Acad. Sci. USA, 2010, vol. 107, no. 8, pp. 3505-3510.

91. Li X., Miao H., Henn A., Topham D.J., Wu H., Zand M.S., Mosmann T.R. Ki-67 expression reveals strong, transient influenza specific CD4 T cell responses after adult vaccination. Vaccine, 2012, vol. 30, no. 31, pp. 4581- 4584.

92. Lin J., Weiss A. T cell receptor signaling. J. Cell Sci., 2001, vol. 114, no. 2, pp. 243-244.

93. Lindenmann M.J., Benczik M., Gaffen S.L. Anti-apoptotic signaling by the inrtleukin-2 receptor reveals a function for cytoplasmic tyrosine residues within the common g (gc) receptor subunit. J. Biol. Chem., 2003, vol. 278, no. 12, pp. 10239-10249.

94. Liu W., Putnam A.L., Xu-Yu Z., Szot G.L., Lee M.R., Zhu S., Gottlieb P.A., Kapranov P., Gingeras T.R., Fazekas de St. Groth B., Clayberger C., Soper D.M., Ziegler S.F., Bluestone J.A. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J. Exp. Med., 2006, vol. 203, no. 7, pp. 1701-1711.

95. Lund F.E., Cockayne D.A., Randall T.D., Solvason N., Schuber F., Howard M.C. CD38: a new paradigm in lymphocyte activation and signal transduction. Immunol. Rev., 1998, no. 161, pp.79-93.

96. Lv G., Ying L., Ma W.J., Jin X., Zheng L., Li L., Yang Y. Dynamic analysis of CD127 expression on memory CD8 T cells from patients with chronic hepatitis B during telbivudine treatment. Virol. J., 2010, vol. 7, no. 207, pp. doi: 10.1186/1743-422X-7-207.

97. MacEwan D.J. TNF ligands and receptors – a matter of life and death. Br. J. Pharmacol., 2002, vol. 135, no. 4, pp. 855-875.

98. Marsee D.K., Pinkus G.S., Yu H. CD71 (transferrin receptor): an effective marker for erythroid precursors in bone marrow biopsy specimens. Am. J. Clin. Pathol., 2010, vol. 134, no. 3, pp. 429-435.

99. Martin P., Gomez M., Lamana A., Cruz-Adalia A., Ramirez-Huesca M., Ursa M.A., Yez-Mo M., Sanchez-Madrid F. CD69 association with Jak3/Stat5 proteins regulates Th17 cell differentiation. Mol. Cell. Biol., 2010, vol. 30, no. 20, pp. 4877-4889.

100. Marzio R., Mauёl J., Betz-Corradin S. CD69 and regulation of the immune function. Immunopharmacol. Immunotoxicol., 1999, vol. 21, no. 3, pp. 565-582.

101. Maszyna F., Hoff H., Kunkel D., Radbruch A., Brunner-Weinzierl M.C. Diversity of clonal T cell proliferation is mediated by differential expression of CD152 (CTLA-4) on the cell surface of activated individual T lymphocytes. J. Immunol., 2003, vol. 171, pp. 3459-3466.

102. Micheau O., Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell., 2003, no. 114, pp. 181-190.

103. Moschovakis G.L., Forster R. Multifaceted activities of CCR7 regulate T-cell homeostasis in health and disease. Eur. J. Immunol., 2012, vol. 42, no. 8, pp. 1949-1955.

104. Mueller Y.M., Makar V., Bojczuk P.M., Witek J., Katsikis P.D. IL-15 enhances the function and inhibits CD95/Fas-induced apoptosis of human CD4+ and CD8+ effector-memory T cells. Int. Immunol., 2003, vol. 15, no. 1, pp. 49-58.

105. Munsaka S.M., Agsalda M., Troelstrup D., Hu N., Yu Q., Shiramizu B. Characteristics of Activated Monocyte Phenotype Support R5-Tropic Human Immunodeficiency Virus. Immunol. Immunogenet. Insights, 2009, vol. 1, pp. 15-20.

106. Myers C.L., Wertheimer S.J., Schembri-King J., Parks T., Wallace R.W. Induction of ICAM-1 by TNF- alpha, IL-1 beta, and LPS in human endothelial cells after downregulation of PKC. Am. J. Physiol., 1992, vol. 263, no. 4, pp. 767-772.

107. Newman R., Schneider C., Sutherland R., Vodinelich L., Greaves M. The transferrin receptor. Proc. Natl. Acad. Sci. USA, 1983, vol. 80, no. 3, pp. 835-839.

108. Noel P.J., Boise L.H., Thompson C.B. Regulation of T cell activation by CD28 and CTLA4. Adv. Exp. Med Biol., 1996, vol. 406, pp. 209-217.

109. Okamoto H., Takasawa S. Recent advances in the okamoto model: the CD38-cyclic ADP-ribose signal system and the regenerating gene protein (reg)-reg receptor system in beta-cells. Diabetes, 2002, vol. 51, pp. 462-473.

110. Olivares M., Walter T., Cook J.D., Hertrampf E., Pizarro F. Usefulness of serum transferrin receptor and serum ferritin in diagnosis of iron deficiency in infancy. Am. J. of Clin. Nutr., 2000, vol. 72, no. 5, pp. 1191-1195.

111. Owens R.M., Gu X., Shin M., Springer T.A., Jin M.M. Engineering of single Ig superfamily domain of intercellular adhesion molecule 1 (ICAM-1) for native fold and function. J. Biol. Chem., 2010, vol. 285, no. 21, pp. 15906-15915.

112. Pandiyan P., Gartner D., Soezeri O., Radbruch A., Schulze-Osthoff K., Brunner-Weinzierl M.C. CD152 (CTLA-4) determines the unequal resistance of Th1 and Th2 cells against activation-induced cell death by a mechanism requiring PI3 kinase function. J. Exp. Med., 2004, vol. 199, pp. 831-842.

113. Paszko E., Vaz G.M., Ehrhardt C., Senge M.O. Transferrin conjugation does not increase the efficiency of liposomal Foscan during in vitro photodynamic therapy of oesophageal cancer. Eur. J. Pharm. Sci., 2013, vol. 48, no. 1-2, pp. 202-210.

114. Pennica D., Nedwin G.E., Hayflick J.S., Seeburg P.H., Derynck R., Palladino M.A., Kohr W.J., Aggarwal B.B., Goeddel D.V. Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin. Nature, 1984, vol. 312, pp. 724-729.

115. Peter M.E., Krammer P.H. The CD95 (APO-1/Fas) DISC and beyond. Cell Death Differ., 2003, vol. 10, pp.26-35.

116. Ranera B., Lyahyai J., Romero A., V zquez F.J., Remacha A.R., Bernal M.L., Zaragoza P., Rodellar C., Mart n-Burriel I. Immunophenotype and gene expression profiles of cell surface markers of mesenchymal stem cells derived from equine bone marrow and adipose tissue. Vet. Immunol. Immunopathol., 2011, vol. 144, no. 1-2, pp. 147-54.

117. Rioux-Leclercq N., Turlin B., Bansard J., Patard J., Manunta A., Moulinoux J.P., Guillé F., Ram e M.P., Lobel B. Value of immunohistochemical Ki-67 and p53 determinations as predictive fac tors of outcome in renal cell carcinoma. Urology, 2000, vol. 55, pp. 501-505.

118. Roebuck K.A., Finnegan A. Regulation of intercellular adhesion molecule-1 (CD54) gene expression. J. Leukoc. Biol., 1999, vol. 66, no. 6, pp. 876-888.

119. Rothlein R., Czajkowski M., Kishimoto T.K. Intercellular adhesion molecule-1 in the inflammatory response. Chem. Immunol., 1991, no. 50, pp. 135-142.

120. Roussev R.G., Dons’koi B.V., Stamatkin C., Ramu S., Chernyshov V.P., Coulam C.B., Barnea E.R. Preimplantation factor inhibits circulating natural killer cell cytotoxicity and reduces CD69 expression: implications for recurrent pregnancy loss therapy. Reprod. Biomed. Online, 2013, vol. 26, no. 1, pp. 79-87.

121. Ryazantseva N.V., Novitskii V.V., Chasovskikh N.Yu., Kaigorodova E.V., Starikova E.G., Starikov Yu.V., Radzivil T.T., Krat I.V. Redox-dependent signal system in regulation of apoptosis under oxidative stress. Cell and Tissue Biology, 2009, vol. 3, no. 4, pp. 311-316.

122. Sabbaj S., Heath S.L., Bansal A., Vohra S., Kilby J.M., Zajac A.J., Goepfert P.A. Functionally competent antigen-specific CD127(hi) memory CD8+ T cells are preserved only in HIV-infected individuals receiving early treatment. J. Infect. Dis., 2007, vol. 195, no. 1, pp. 108-117.

123. Sanchez J., Casano J., Alvarez M.A.. Roman-Gomez J., Martin C., Martinez F., Gomez P., Serrano J., Herrera C., Torres A. Kinetic of regulatory CD25high and activated CD134+ (OX40) T lymphocytes during acute and chronic graft-versus-host disease after allogeneic bone marrow transplantation. Br. J. Haematol., 2004, vol. 126, no. 5, pp. 697-703.

124. Sandoval-Montes C., Santos-Argumedo L. CD38 is expressed selectively during the activation of a subset of mature T-cells with redused proliferation but improved potential to produce cytokines. Leukocyte Biology, 2005, vol. 77, pp. 513-521.

125. Sasson S.C., Zaunders J.J., Seddiki N., Bailey M., McBride K., Koelsch K.K., Merlin K.M., Smith D.E., Cooper D.A., Kelleher A.D. Progressive activation of CD127+132- recent thymic emigrants into terminally differentiated CD127-132+ T-cells in HIV-1 infection. PLoS One, 2012, vol. 7, no. 2, pp. e31148.

126. Scholzen T., Gerdes J. The Ki-67 protein: from the known and the unknown. J. Cell. Physiol., 2000, vol. 182, no. 3, pp. 311-322.

127. Sheikh N.A., Jones L.A. CD54 is a surrogate marker of antigen presenting cell activation. Cancer Immunol. Immunother., 2008, vol. 57, no. 9, pp. 1381-1390.

128. Shinoda K., Tokoyoda K., Hanazawa A., Hayashizaki K., Zehentmeier S., Hosokawa H., Iwamura C., Koseki H., Tumes D.J., Radbruch A., Nakayama T. Type II membrane protein CD69 regulates the formation of resting T-helper memory. Proc. Natl. Acad. Sci. USA, 2012, vol. 109, no. 19, pp. 7409-7414.

129. Shipkova M., Wieland E. Surface markers of lymphocyte activation and markers of cell proliferation. Clin. Chim. Acta., 2012, vol. 413, no. 17-18, pp. 1338-1349.

130. Shu H.B., Takeuchi M., Goeddel D.V. The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of thetumor necrosis factor receptor 1 signaling complex. Proc. Natl. Acad. Sci. USA, 1996, vol. 93, no. 24, pp. 13973-13978.

131. Simonetta F., Chiali A., Cordier C., Urrutia A., Girault I., Bloquet S., Tanchot C., Bourgeois C. Increased CD127 expression on activated FOXP3+CD4+ regulatory T cells. Eur. J. Immunol., 2010, vol. 40, no. 9, pp. 2528- 2538.

132. Soares A., Govender L., Hughes J., Mavakla W., de Kock M., Barnard C., Pienaar B., Janse van Rensburg E., Jacobs G., Khomba G., Stone L., Abel B., Scriba T.J., Hanekom W.A. Novel application of Ki67 to quantify antigen- specific in vitro lymphoproliferation. J. Immunol. Methods, 2010, vol. 362, no. 1-2, pp. 43-50.

133. Soliman H., Rawal B., Fulp J., Lee J.H., Lopez A., Bui M.M., Khalil F., Antonia S., Yfantis H.G., Lee D.H., Dorsey T.H., Ambs S. Analysis of indoleamine 2-3 dioxygenase (IDO1) expression in breast cancer tissue by immunohistochemistry. Cancer Immunol. Immunother., 2013, vol. 62, no. 5, pp. 829-837.

134. Stites D., Casavant C., McHugh T., Moss A.R., Beal S.L., Ziegler J.L., Saunders A.M., Warner N.L. Flow cytometric analysis of lymphocyte phenotypes in AIDS using monoclonal antibodies and simultaneous dual immunofluorescence. Clin. Immunol. Immunopathol, 1986, vol. 38, pp.161-177.

135. Strasser A., Newton K. FADD/MORT1, a signal transducer that can promote cell death or cell growth. Int. J. Biochem. Cell Biol., 1999, no. 31, pp. 533-537.

136. Strasser A., Jost P.J., Nagata S. The many roles of FAS receptor signaling in the immune system. Immunity, 2009, vol. 30, no. 2, pp. 180-192.

137. Takada H., Chen N.J., Mirtsos C., Suzuki S., Suzuki N., Wakeham A., Mak T.W., Yeh W.C. Role of SODD in regulation of tumor necrosis factor responses. Mol. Cell. Biol., 2003, vol. 23, pp. 4026-4033.

138. Tang D.G., Honn K.V. Adhesion molecules and tumor metastasis: an update. Invasion Metastasis, 1994-1995, vol. 14, no. 1-6, pp. 109-122.

139. Tereshchenko S., Babushkin V.A., Ol’khovski I.A., Novitski I.A., Isakov I.V., Shakina N.A. The phenotype IFNγ+cd69- of T-lymphocytes of umbilical blood associated with epidemiologically verified risk factors of atopy formation. Klin. Lab. Diagn., 2012, vol. 6, pp. 50-52.

140. Thompson C.B., Allison J.P. The emerging role of CTLA-4 as an immune attenuator. Immunity, 1997, vol. 7, no. 4, pp. 445-450.

141. Tomkinson B.E., Wagner D.K., Nelson D.L., Sullivan J.L. Activated lymphocytes during acute Epstein-Barr virus infection. J. Immunol., 1987, vol. 139, pp. 3802-3807.

142. Uehara T., Miyawaki T., Ohta K., Tamaru Y., Yokoi T., Nakamura S., Taniguchi N. Apoptotic cell death of primed CD45RO+ T lymphocytes in Epstein-Barr virus-induced infectious mononucleosis. Blood, 1992, vol. 80, no. 2, pp. 452-458.

143. Urbani S., Amadei B., Fisicaro P., Tola D., Orlandini A., Sacchelli L., Mori C., Missale G., Ferrari C. Outcome of acute hepatitis C is related to virus-specific CD4 function and maturation of antiviral memory CD8 responses. Hepatology, 2006, vol. 44, no. 1, pp. 126-139.

144. Wajant H. Death receptors. Essays Biochem., 2003, no. 39, pp. 53-71.

145. Waldmann T. A. The interleukin-2 receptor. J. Biol. Chem., 1994, vol. 266, no. 5, pp. 2681-2684.

146. Wang L., Du F., Wang X. TNF-α Induces Two Distinct Caspase-8 Activation Pathways Cell, 2008, vol. 133, no. 4, pp. 693-703.

147. Wojciechowski S., Jordan M.B., Zhu Y., White J., Zajac A.J., Hildeman D.A. Bim mediates apoptosis of CD127(lo) effector T cells and limits T cell memory. Eur. J. Immunol., 2006, vol. 36, no. 7, pp. 1694-1706.

148. Wong M., Ziring D., Korin Y., Desai S., Kim S., Lin J., Gjertson D., Braun J., Reed E., Singh R.R. TNFα blockade in human diseases: Mechanisms and future directions. Clin. Immunol., 2008, vol. 126, no. 2, pp. 121-136.

149. Yoshino T., Kondo E., Cao L., Takahashi K., Hayashi K., Nomura S., Akagi T. Inverse expression of bcl-2 protein and Fas antigen in lymphoblasts in peripheral lymph nodes and activated peripheral blood T and B lymphocytes. Blood, 1994, vol. 83, no. 7, pp. 1856-1861.

150. Zaunders J.J., Dyer W.B., Munier M.L., Ip S., Liu J., Amyes E., Rawlinson W., De Rose R., Kent S.J., Sullivan J.S., Cooper D.A., Kelleher A.D. CD127+CCR5+CD38+CD4+ Th1 effector cells are an early component of the primary immune response to vaccinia virus and precede development of interleukin-2+ memory CD4+ T cells. J. Virol., 2006, vol. 80, no. 20, pp. 10151-10161.

151. Zhang Y.Y., Huang X.M., Kang M.L., Gong F.Q., Qian B.Q. Changes in CD69, CD25 and HLA-DR expressions in peripheral blood T cells in Kawasaki disease]. Zhonghua Er Ke Za Zhi., 2006, vol. 44, no. 5, pp. 329-332.

152. Zhao Q., Kuang D.M., Wu Y., Xiao X., Li X.F., Li T.J., Zheng L. Activated CD69+ T cells foster immune privilege by regulating IDO expression in tumor-associated macrophages. J. Immunol., 2012, vol. 188, no. 3, pp. 1117-11124.

153. Ziegler E., Oberbarnscheidt M., Bulfone-Paus S., F rster R., Kunzendorf U., Krautwald S. CCR7 signaling inhibits T cell proliferation. J. Immunol., 2007, vol. 179, no. 10, pp. 6485-6493.


Для цитирования:


Литвинова Л.С., Гуцол А.А., Сохоневич Н.А., Кофанова К.А., Хазиахматова О.Г., Шуплецова В.В., Кайгородова Е.В., Гончаров А.Г. ОСНОВНЫЕ ПОВЕРХНОСТНЫЕ МАРКЕРЫ ФУНКЦИОНАЛЬНОЙ АКТИВНОСТИ Т-ЛИМФОЦИТОВ. Медицинская иммунология. 2014;16(1):7-26. https://doi.org/10.15789/1563-0625-2014-1-7-26

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Litvinova L.S., Gutsol A.A., Sokhonevich N.A., Kofanova K.A., Khaziakhmatova O.G., Shupletsova V.V., Kaigorodova E.V., Goncharov A.G. BASIC SURFACE MARKERS OF FUNCTIONAL ACTIVITY T-LYMPHOCYTES. Medical Immunology (Russia). 2014;16(1):7-26. (In Russ.) https://doi.org/10.15789/1563-0625-2014-1-7-26

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