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Медицинская иммунология

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МЕТИЛИРОВАНИЕ ДНК КЛЕТКИ И ПАТОЛОГИЯ ОРГАНИЗМА

https://doi.org/10.15789/1563-0625-2008-4-5-307-318

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Аннотация

Резюме. Несмотря на устоявшиеся представления о существовании явных различий в патогенезе основных заболеваний (рак, атеросклероз, аутоиммунные и аллергические заболевания), имеются основания думать о существовании неких фундаментальных процессов, лежащих в основе развития всех этих заболеваний, составляющих общую, единую часть их патогенеза. К таким процессам следует отнести процессы метилирования и деметилирования ДНК, ацетилирования и деацетилирования гистонов, процесс укорочения теломер, связанный с активностью теломеразы. Оказывается, что, по крайней мере, рак, атеросклероз, аутоиммунные заболевания характеризуются процессами тотального гипометилирования ДНК в различного рода клеточных элементах на фоне возвратного гиперметилирования отдельных генов. Предполагается, что данные об этих единых механизмах развития различных патологических процессов могут ставить вопрос о разработке единых методов терапии данных заболеваний, естественно, на фоне совершенствования методов лечения, специфических для отдельно взятой патологии.

Об авторе

В. А. Козлов
ГУ НИИ клинической иммунологии СО РАМН, г. Новосибирск
Россия

Кафедра клинической иммунологии НГМУ

630090, г. Новосибирск-91, ул. Ядринцевская, 14

 



Список литературы

1. Козлов В.А., Журавкин И.Н., Цырлова И.Г. Стволовая кроветворная клетка и иммунный ответ. – Новосибирск: Наука, 1982. – 221 с.

2. Патрушев Л.И. Экспрессия генов. – М.: Наука, 2000. – 527 с.

3. Balada E., Ordi-Ros J., Serrano-Acedo S., Martinez-Lostano L., Vilardell-Tarres M. Transcript overexpression of the MBD2 and MBD4 genes in CD4+ T cells from systemic lupus erythematosus patients // J. Leukoc. Biol. – 2007. – Vol. 81, N 6. – P. 1609-1619.

4. Ballestar E., Esteller M., Richardson B.C. The epigenetic face of systemic lupus erythematosus // J. Immunol. – 2006. – Vol. 176. – P. 7143-7147.

5. Bird J.J., Brown D.R., Mullen A.C., Moskowitz N.H., Mahowald M.A., Sider J.R., Gajewski T.F., Wang C-R., Reiner S.L. Helper T cell differentiation is controlled by the cell cycle // Immunity. – 1998. Vol. 9, N 2. – P. 229-237.

6. Castro R., Rivera I., Struys E.A., Jansen E.E., Ravasco P., Camilo M.E., Blom H.J., Jakobs C., Tavares de Almeida I. Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease // Clin. Chemistry. – 2003. – Vol. 49, N 8. – P. 1292-1296.

7. Chappell C., Beard C., Altman J., Jaenisch R., Jacob J. DNA methylation by DNA methyltransferase 1 is critical for effector CD8 T Cell expansion // J. Immunol. – 2006. – Vol. 176, N 11. – P. 4562-4572.

8. Dong C., Yoon W., Goldsmidt-Clermont P.J. DNA methylation and atherosclerosis // J. Nutr. – 2002. – Vol. 132. – P. 2406S-2409S.

9. Egger G., Liang G., Aparicio A., Jones P.A. Epigenetics in human disease and prospects for epigenetic therapy // Nature. – 2004. – Vol. 429, N 6990. – P. 457-563.

10. Feltus F.A., Lee E.K., Costello J.F., Plass C., Vertino P.M. Predicting aberrant CpG island methylation // PNAS. – 2003. – Vol. 100, N 21. – P. 12253-12258.

11. Fu L.H., Cong B., Zhen Y.F., Li S.J., Ma C.L., Ni Z.Y., Zhang G.Z., Zuo M., Yao Y.X. Methylation status of the IL-10 gene promoter in the peripheral blood mononuclear cells of rheumatoid arthritis parients // Yi Chuan. – 2007. – Vol. 29, N 11. – P. 1357-1361.

12. Hayden M.R., Tyagi S.C. Homocysteine and reactive oxygen species in metabolic syndrome, type 2 diabetes mellitus, and atheroscleropathy: the pleiotropic effects of folate supplementation // Nutrition J. – 2004. – N 3. – P. 1-23.

13. Hiltunen M.O., Turunen M.P., Häkkinen T.P., Rutanen J., Hedman M., Mäkinen K., Turunen A.M., Aalto-Setälä K., Ylä-Herttuala S. DNA hypomethylation and methyltransferase expression in atherosclerotic lesions // Vasc. Med. – 2002. – Vol. 7, N 1. – P. 5-11.

14. Hiltunen M.O., Yla-Herttuala S. DNA methylation, smooth muscle cells, and atherogenesis // Arterioscler. Thromb. Vasc. Biol. – 2003. – Vol. 13. – P. 1750-1753.

15. Hutchins A.S., Artis D., Hendrich B.D., Bird A.P., Scott P., Reiner S.L. Cutting edge: a critical rolw for gene silencing in preventing excessive type 1 Immunity // J. Immunol. – 2005. – Vol. 175, N 10. – P. 5606-5610.

16. Ihling C., Haendeler J., Menzel G., Hess R.D., Fraedrich G., Schaefer H.E., Zeiher A.M. Co-expression of p53 and MDM2 in human atherosclerosis: implications for the regulation of cellularity of atherosclerotic lesions // J. Pathol. – 1999. – Vol. 185, N 3. – P. 303-312.

17. Ingrosso D., Cimmino A., Perna A.F., Masella L., De Santo N.G., De Bonis M.L., Vacca M., D'Esposito M., D'Urso M., Galletti P., Zappia V. Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia // The Lancet. – 2003. – Vol. 361, N 9370. – P. 1693-1699.

18. Kersh E.N., Fitzpatrick D.R., Murali-Krishna K., Shives J., Speck S.H., Boss J.M., Ahmed R. Rapid demethylation of the IFN-gamma gene occurs in memory but not naive D8 T cells // J. Immunol. – 2006. – Vol. 176, N 7. – P. 4083-4093.

19. Kim H-R., Hwang K-A., Kim K.C., Kang I. Down-regulation of IL-7Rα expression in human T cells via DNA methylation // J. Immunol. – 2007. Vol. 178, N 11. – P. 5473-5479.

20. Kwon N.H., Kim J.S., Lee J.Y., Oh M.J., Choi D.C. DNA methylation and the expression of IL-4 and IFN-gamma promoter genes in patients with bronchial asthma // J. Clin. Immunol. – 2007. – Vol. 28, N 2. – P. 139-146.

21. Lee W.J., Kim H.J. Inhibition of DNA methylation is involved in transdifferentiation of myoblasts into smooth muscle cells // Mol. Cells. – 2007. – Vol. 24, N 3. – P. 441-444.

22. Li E. The mojo of methylation // Nature Genetics. – 1999. – Vol. 23, N 1. – P. 5-6.

23. Luczak M.W., Jagodzinski P.P. The role of DNA methylation in cancer development // Folia Histochemica et Cytobiologica. – 2006. – Vol. 44, N 3. – P. 143-154.

24. Lund G., Andersson L., Lauria M., Lindholm M., Fraga M.F., Villar-Garea A., Ballestar E., Esteller M., Zaina S. DNA methylation polymorphisms precede any histological sign of atherosclerosis in mice lacking apolipoprotein E // J. Biol. Chemistry. – 2004. – Vol. 279, N 28. – P. 29147-29154.

25. Lyko F., Brown R. DNA methyltransferasa inhibitor and the development of epigenetics cancer therapies // J. Natl. Cancer Inst. – 2005. – Vol. 97, N 20. – P. 1498-1506.

26. Marin M.L., Gordon R.E., Veith F.J., Tulchin N., Panetta T.F. Distribution of c-myc oncoprotein in healthy and atherosclerotic human carotid arteries // J. Vasc. Surg. – 1993. – Vol. 18, N 2. – P. 170-176.

27. Murry C.E., Gipaya C.T., Bartosek T., Benditt E.P. Schwartz S.M. Monoclonality of smooth muscle in human atherosclerosis // Am. J. Pathol. – 1997. – Vol. 151. – P. 697-705.

28. Nakamura T., Sekigawa I., Ogasawara H., Mitsuishi K., Hira K., Ikeda S., Ogawa H. Expression of DNMT-1 in patients with atopic dermatitis // Arch. Dermatol. Res. – 2006. – Vol. 298, N 5. – P. 253-256.

29. Post W.S., Goldschmidt-Clermont P.J., Wilhide C.C., Heldman A.W., Sussman M.S., Ouyang P., Milliken E.E., Issa J.P. Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system // Cardiovascular Res. – 1999. – Vol. 43. – P. 985-991.

30. Qing Ya., Thien V.T., Kaplan M.H. Stat4 limits DNA methyltransferase recruitment and DNA methylation of the IL-18Rα gene during Th1 differentiation // EMBO J. – 2007. – Vol. 26. – P. 2052-2060.

31. Rauch T., Wang Z., Zhang X., Zhong X., Wu X., Lau S.K., Kernstine K.H., Riggs A.D., Pfeifer G.P. Homeobox gene methylation in lung cancer studied by genome-wide analysis with a microarray-based methylated CpG island recovery assay // PNAS. – 2007. – Vol. 104, N 13. – P. 5527-5532.

32. Reiss D., Zhang Y., Mager D.L. Widely variable endogenous retroviral methylation levels in human placenta // Nucleic Acids Res. – 2007. – Vol. 35, N 14. – P. 4743-4754.

33. Robertson K.D. DNA methylation and human disease // Nature Reviews. Genetics. – 2005. – Vol. 6. – P. 597-610.

34. Rodenhiser D., Mann M. Epigenetics and human disease: translating basic biology into clinical application // CMAJ. – 2006. – Vol. 174, N 3. – P. 341-348.

35. Sanders V.M. Epigenetic regulation of Th1 and Th2 cell development // Brain, Behavior, and Immunity. – 2006. – Vol. 20. – P. 317-324.

36. Sano H., Compton L.J., Steinberg A.D., Jackson R.A., Sasaki T. Low expression of human histocompatibility leukocyte antigen-DR is associated with hypermethylation of human histocompatibility leukocyte antigen-DR gene regions in B cells from patients with systemic lupus erythematosus // J. Clin. Invest. – 1985. – Vol. 76, N 4. – P. 1314-1322.

37. Scarano M.I., Strazzullo M., Matarazzo R., D’Esposito M. DNA methylation 40 years later: its role in human health and disease // J. Cell. Physiol. – 2005. – Vol. 204, N 1. – P. 21-35.

38. Sekigawa I., Kawasaki M., Ogasawara H., Kaneda K., Kaneko H., Nakasaki Y., Ogawa H. DNA methylatioan: its contribution to systemic lupus erythematosus // Clin. Exp. Med. – 2006. – Vol. 6, N 3. – P. 99-106.

39. Shen L., Catalano P.J., Benson A.B. 3rd, O’Dwyer P., Hamilton S.R., Issa J-P J. Association between DNA methylation and shortened survival in patients with advanced colorectal cancer treated with 5-fluorouracil-based chemotherapy // Clin. Cancer Res. – 2007. – Vol. 13. – P. 6093-6098.

40. Shibata K.R., Aoyama T., Shima Y., Fukiage K., Otsuka S., Furu M., Ito K., Fujibayashi S., Neo M., Nakayama T., Toguchida J. Expression of the p161NK4A gene is associated closely with senescence of human mesenchymal stem cells and is potentially silenced by DNA methylation during in vitro expansion // Stem Cells. – 2007. – Vol. 25, N 9. – P. 2371-2382.

41. Shin H.J., Jeong S.J., Park H.W., Kim Y.K., Cho S.H., Kim Y.Y., Cho M.L., Kim H.Y., Min K.U., Lee C.W. STAT4 expression in human T cells is regulated by DNA methylation but not by promoter polymorphism // J. Immunol. – 2005. – Vol. 175, N 11. – P. 7143-7150.

42. Sugino Y., Misawa A., Inoue J., Kitagawa M., Hosoi H., Sugimoto T., Imoto I., Inazawa J. Epigenetic silencing of prostaglandin E 2 (PTGER2) is associated with progression of neuroblastomas // Oncogene. – 2007. – Vol. 26, N 53. – P. 7401-7413.

43. Tadokoro Y., Ema H., Okano M., Li E., Nakauchi H. De novo DNA methyltransferase is essential for self-reneval, but not for differentiation, in hematopoietic stem cells // J. Exp. Med. – 2007. – Vol. 204, N 4. – P. 715-722.

44. Takami N., Osawa K., Miura Y., Komani K., Taniguchi M., Shiraishi M., Sato K., Iguchi T., Shiozawa K., Hashiramoto A., Shiozawa S. Hypermethylated promoter region of DR3, the death receptor 3 gene, in rheumatoid arthritis synovial cells // Arthritis Rheum. – 2006. – Vol. 54, N 3. – P. 779-787.

45. van Vliet J., Oates N.A., Whitelaw. Epigenetic mechanisms in context in the complex diseases // Cell. Mol. Life Sci. – 2007. – Vol. 64. – P. 1531-1538.

46. Vivekanandan P., Thomas D., Torbenson M. Hepatitis B viral DNA is methylated in liver tissues // J. Viral. Hepat. – 2008. – Vol. 15, N 2. – P. 103-107.

47. Waggoner D. Mechanisms of disease: epigenesist // Semin Pediatr. Neurol. – 2007. – Vol. 14. – P. 7-14.

48. Wen Z.K., Xu W., Xu L., Cao Q.H., Wang Y., Chu Y.W., Xiong S.D. DNA hypomethylation is crucial for apoptotic DNA to induce systemic lupus erythematosus-like autoimmune desease in SLE-non-susceptible mice // Rheumatology. – 2007. – Vol. 46, N 12. – P. 1796-1803.

49. White G.P., Hollams E.M., Yerkovich S.T., Bosco A., Holt B.J., Bassami M.R., Kusel M., Sly P.D., Holt P.G. CpG methylation patterns in the IFNgamma promoter in naive T cells: variation during Th1 and Th2 differentiation and between atopic and non-atopics // Pediatr. Allergy Immunol. – 2006. – Vol. 17, N 8. – P. 557564.

50. Yano S., Glosh P., Kusaba H., Buchholz M., Longo D.l. Effect of promoter methylation on the regulation of IFN-gamma gene during in vitro differentiation of human peripheral blood T cells into a Th2 population // J. Immunol. – 2003. – Vol. 171, N 5. – P. 2510-2516.

51. Ying A.K., Hassanain H.H., Roos C.M., Smiraglia D.J., Issa J.J., Michler R.E., Caligiuri M., Plass C., Goldschmidt-Clermont P.J. Methylation of the estrogen receptor-a gene promoter is selectively increased in proliferating human aortic smooth muscle cells // Cardiovasc. Res. – 2000. – Vol. 46. – P. 172-179.

52. Yoder J.A., Walsh C.P., Bestor T.H. Cytosine methylation and the ecology of intragenomic parasites // Trends Genet. – 1997. – Vol. 13, N 3. – P. 335-340.

53. Zaina S., Lindholm M.W., Lund G. Nutrition and aberrant DNA methylation patterns in atherosclerosis: More than just hyperhomocysteinemia? // J. Nutr. – 2005. – Vol. 135, N 1. – P. 5-8.


Для цитирования:


Козлов В.А. МЕТИЛИРОВАНИЕ ДНК КЛЕТКИ И ПАТОЛОГИЯ ОРГАНИЗМА. Медицинская иммунология. 2008;10(4-5):307-318. https://doi.org/10.15789/1563-0625-2008-4-5-307-318

For citation:


Kozlov V.A. METHYLATION OF CELLULAR DNA AND PATHOLOGY OF THE ORGANISM. Medical Immunology (Russia). 2008;10(4-5):307-318. (In Russ.) https://doi.org/10.15789/1563-0625-2008-4-5-307-318

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