References

mimmun

Медицинская иммунология

Medical Immunology (Russia)

1563-06252313-741X

SPb RAACI

10.15789/1563-0625-2008-4-5-307-318

mimmun-178

Research Article

ОБЗОРЫ

REVIEWS

МЕТИЛИРОВАНИЕ ДНК КЛЕТКИ И ПАТОЛОГИЯ ОРГАНИЗМА

METHYLATION OF CELLULAR DNA AND PATHOLOGY OF THE ORGANISM

Козлов

В. А.

Kozlov

V. A.

Кафедра клинической иммунологии НГМУ

v_kozlov@online.nsk.su

ГУ НИИ клинической иммунологии СО РАМН, г. НовосибирскRussian Federation

2008

17072014

104-5307318

2014

Козлов В.А.

Kozlov V.A.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.mimmun.ru/mimmun/article/view/178

Abstract. In spite of stable opinions concerning clear pathogenetic differences in main disease states (i.e., cancer, atherosclerosis, autoimmune and allergic diseases), there are sufficient reasons to assume some fundamental processes, that are common to development of these diseases, and represent a general factor of their pathogenesis. Such processes include, e.g., DNA methylation and demethylation events, acetylation and deacetylation of histones, the processes of telomere shortening connected with telomerase activity. It proves that, at least, cancer, atherosclerosis, and autoimmune diseases are characterized by total hypomethylation of different cellular elements, against «recurrent» DNA hypermethylation of single specific genes in the background. It is assumed that information about such common developmental mechanisms for different disease states may evoke an issue of a search for some common approaches to treatment of these diseases, along with elaboration of conventional treatment modalities, being specific to individual pathology. (Med. Immunol., vol. 10, N 4-5, pp 307-318).

метилированиеДНКгистоныацетилированиегены

methylationDNAhistonesacetylationgene

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The authors declare that there are no conflicts of interest present.