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Медицинская иммунология

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КЛЕТОЧНАЯ ИММУНОТЕРАПИЯ – СОВРЕМЕННЫЙ ПОДХОД К ЛЕЧЕНИЮ ОНКОЛОГИЧЕСКИХ ЗАБОЛЕВАНИЙ

https://doi.org/10.15789/1563-0625-2018-3-313-340

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Аннотация

Выяснение механизмов врожденного иммунитета, отвечающих за защиту от возникновения злокачественных опухолей, способствует разработке новых подходов к терапии рака, основанных на активации иммунной системы пациента. Ранее иммунотерапия рака базировалась на подходах к активации иммунных механизмов противоопухолевой защиты путем разного рода неспецифических иммуностимуляторов, введения цитокинов и прочих белковых факторов, а также создания противораковых вакцин на основе опухолевых клеток. Новые данные о разнообразии взаимодействий между иммунными и опухолевыми клетками, позволяют использовать для терапии рака и препараты на основе самих иммунных клеток. В частности, активно испытывается эффективность трансплантации противоопухолевых иммунных клеток, экспансия активных популяций иммунных клеток ex vivo, приемы, приводящие к повышению их противоопухолевой активности и специфичности. На стадии разработки находятся подходы к нацеливанию иммунных клеток на определенные раковые антигены, конверсии супрессирующего действия клеток опухолевого микроокружения в противоопухолевое, а также к использованию иммунных клеток для подавления развития опухолевой инфраструктуры. В обзоре оцениваются перспективы развития клеточной иммунотерапии опухолей и области их применения.

Об авторах

Ю. Н. Лежнин
ФГБУН «Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова» Российской академии наук
Россия

Аспирант.

Москва



А. Ю. Христиченко
ФГБУН «Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова» Российской академии наук
Россия

Аспирант.

Москва



Н. М. Ратникова
ФГБУН «Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова» Российской академии наук
Россия

Аспирант.

Москва



Ю. Е. Кравченко
ФГБУН «Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова» Российской академии наук
Россия

Кандидат биологических наук, научный сотрудник.

Москва



С. П. Чумаков
ФГБУН «Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова» Российской академии наук
Россия

Чумаков Степан Петрович – кандидат биологических наук, научный сотрудник.

117997, Москва, ГСП-7,  ул. Миклухо-Маклая, 16/10, тел.: 8 (915) 006-69-68



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Для цитирования:


Лежнин Ю.Н., Христиченко А.Ю., Ратникова Н.М., Кравченко Ю.Е., Чумаков С.П. КЛЕТОЧНАЯ ИММУНОТЕРАПИЯ – СОВРЕМЕННЫЙ ПОДХОД К ЛЕЧЕНИЮ ОНКОЛОГИЧЕСКИХ ЗАБОЛЕВАНИЙ. Медицинская иммунология. 2018;20(3):313-340. https://doi.org/10.15789/1563-0625-2018-3-313-340

For citation:


Lezhnin Y.N., Khristichenko A.Y., Ratnikova N.M., Kravchenko Y.E., Chumakov S.P. CELLULAR IMMUNOTHERAPY: A MODERN APPROACH TO TREATMENT OF ONCOLOGICAL DISEASES. Medical Immunology (Russia). 2018;20(3):313-340. (In Russ.) https://doi.org/10.15789/1563-0625-2018-3-313-340

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