References

mimmun

Медицинская иммунология

Medical Immunology (Russia)

1563-06252313-741X

SPb RAACI

10.15789/1563-0625-2018-3-313-340

mimmun-1535

Research Article

ОБЗОРЫ

REVIEWS

КЛЕТОЧНАЯ ИММУНОТЕРАПИЯ – СОВРЕМЕННЫЙ ПОДХОД К ЛЕЧЕНИЮ ОНКОЛОГИЧЕСКИХ ЗАБОЛЕВАНИЙ

CELLULAR IMMUNOTHERAPY: A MODERN APPROACH TO TREATMENT OF ONCOLOGICAL DISEASES

Лежнин

Ю. Н.

Lezhnin

Yu. N.

Аспирант.

Москва

Research Fellow.

Moscow

Христиченко

А. Ю.

Khristichenko

A. Yu.

Аспирант.

Москва

Research Fellow.

Moscow

Ратникова

Н. М.

Ratnikova

N. M.

Аспирант.

Москва

Research Fellow.

Кравченко

Ю. Е.

Kravchenko

Yu. E.

Кандидат биологических наук, научный сотрудник.

Москва

PhD (Biology).

Чумаков

С. П.

Chumakov

S. P.

Чумаков Степан Петрович – кандидат биологических наук, научный сотрудник.

117997, Москва, ГСП-7, ул. Миклухо-Маклая, 16/10, тел.: 8 (915) 006-69-68

Chumakov Stepan P. - PhD (Biology).

117997, Moscow, Miklukho-Maklaya str., 16/10, Phone: 7 (915) 006-69-68

stepan@chumakov.email

ФГБУН «Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова» Российской академии наукРоссияShemyakin–Ovchinnikov Institute of Bioorganic ChemistryRussian Federation

2018

10062018

203313340

2018

Лежнин Ю.Н., Христиченко А.Ю., Ратникова Н.М., Кравченко Ю.Е., Чумаков С.П.

Lezhnin Y.N., Khristichenko A.Y., Ratnikova N.M., Kravchenko Y.E., Chumakov S.P.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.mimmun.ru/mimmun/article/view/1535

Выяснение механизмов врожденного иммунитета, отвечающих за защиту от возникновения злокачественных опухолей, способствует разработке новых подходов к терапии рака, основанных на активации иммунной системы пациента. Ранее иммунотерапия рака базировалась на подходах к активации иммунных механизмов противоопухолевой защиты путем разного рода неспецифических иммуностимуляторов, введения цитокинов и прочих белковых факторов, а также создания противораковых вакцин на основе опухолевых клеток. Новые данные о разнообразии взаимодействий между иммунными и опухолевыми клетками, позволяют использовать для терапии рака и препараты на основе самих иммунных клеток. В частности, активно испытывается эффективность трансплантации противоопухолевых иммунных клеток, экспансия активных популяций иммунных клеток ex vivo, приемы, приводящие к повышению их противоопухолевой активности и специфичности. На стадии разработки находятся подходы к нацеливанию иммунных клеток на определенные раковые антигены, конверсии супрессирующего действия клеток опухолевого микроокружения в противоопухолевое, а также к использованию иммунных клеток для подавления развития опухолевой инфраструктуры. В обзоре оцениваются перспективы развития клеточной иммунотерапии опухолей и области их применения.

Our understanding of anticancer immune surveillance currently serves as a basis for development of novel therapies that utilize patient’s own immune system as an anticancer agent. Previously, cancer immunotherapy mostly included non-specific immunomodulating agents, cytokines, or cancer cell-based tumor vaccines. Emerging understanding of diverse interactions between the immune system and cancer cells allows to develop novel, more effective therapeutic approaches that target only specific populations of immune cells. Recent studies focus on testing efficiency of allogenic and authologous anticancer immunity, strategies for ex vivo expansion of these cells, and approaches to increase their anticancer activity and specificity. Most recent approaches focus on re-targeting immune cells to specific tumor antigens, shifting the balance of immunosuppressive tumor microenvironment towards immune stimulation and utilizing immune cells to target tumor architecture. This review is focused on the prospects of different immuno-therapeutic strategies.

клеточная иммунотерапиятерапевтические антителаадоптивная иммунотерапияденритноклеточные вакциныхимерные рецепторы

сellular immunotherapytherapeutic antibodiesadoptive immunotherapycancer vaccinechimeric antigen receptor

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The authors declare that there are no conflicts of interest present.