ЭФФЕКТЫ γc-ЦИТОКИНОВ (IL-2, IL-7 И IL-15) НА СОЗРЕВАНИЕ И ДИФФЕРЕНЦИРОВКУ CD45RО⁺CD4⁺/ CD8⁺Т-ЛИМФОЦИТОВ IN VITRO

Исследовано влияние γс-цитокинов (IL-2, IL-7 и IL-15) на созревание и дифференцировку цитотоксических и хелперных популяций CD45RО⁺Т-клеток в условиях гомеостатического культивирования in vitro. Выявлено, что IL-2, IL-7 и IL-15 опосредуют созревание и дифференцировку CD8+Т-лимфоцитов центральной памяти, пополняя популяцию клеток, обладающих эффекторными функциями. Действие IL-2 на CD4⁺Т-клетки центральной памяти сопровождается генерацией клеток эффекторной памяти за счет снижения числа незрелых эффекторов – CD62L–CD27⁺, тогда как IL-7 стимулирует образование незрелых эффекторов – CD62L–CD27+. В субпопуляции CD8⁺CD45RО⁺ лимфоцитовIL-2, IL-7 и IL-15 инициируют образование терминально-дифференцированных клеток, обеспечивающих устойчивую иммунологическую память на реинвазию патогена.

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