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Медицинская иммунология

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АКТИВАЦИЯ ИММУНИТЕТА ПРИ ВИЧ-ИНФЕКЦИИ

https://doi.org/10.15789/1563-0625-2017-5-489-504

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Аннотация

Данный литературный обзор посвящен актуальной проблеме ВИЧ-инфекции – актива-ции иммунитета. Иммунная активация в значительной мере определяет утрату CD4+T-лимфоцитов, приводит к развитию СПИД-ассоциированных и СПИД-неассоциированных заболеваний, а ее по-казатели являются весомыми прогностическими факторами исхода болезни. Активация при ВИЧ-инфекции захватывает клетки как врожденного, так и адаптивного иммунитета, ведет к усилению продукции провоспалительных цитокинов и повышению коагуляции крови. Причиной развития иммунной активации могут быть инфекционные агенты (ВИЧ, цитомегаловирус, вирус Эпштейна– Барр, вирус гепатита C), лимфопения и индуцированный ею процесс гомеостатической пролифе-рации лимфоцитов, транслокация микробов и их продуктов из кишечника, что связано с глубоким дефицитом CD4+T-клеток в lamina propria и нарушением проницаемости кишечного барьера. Други-ми факторами, поддерживающими процесс активации иммунитета, являются «сторонняя» актива-ция T-лимфоцитов, усиление оборота T-клеток, развитие системного воспаления. В работе не только рассмотрены патогенетические механизмы развития ВИЧ-инфекции, связанные с синдромом им-мунной активации, но также приведены различные лабораторные параметры, характеризующие ее проявление у инфицированных пациентов. Представлены значение и прогностическая роль этих па-раметров в оценке эффективности антиретровирусной терапии, формировании осложнений и нега-тивного исхода инфекции.

Об авторах

К. В. Шмагель
ФГБУН «Институт экологии и генетики микроорганизмов» УрО РАН; ФГБОУ ВПО «Пермский государственный национальный исследовательский университет».
Россия

Шмагель К.В. – доктор медицинских наук, заведующий лабораторией экологической иммунологии ГБУН «Институт экологии и генетики микроорганизмов» УрО РАН; ФГБОУ ВПО «Пермский государственный национальный исследовательский университет».

614081, г.Пермь, ул.Голева, 13.



Н. Г. Шмагель
ФГБОУ ВПО «Пермский государственный национальный исследовательский университет»; ГКУЗ «Пермский краевой центр по борьбе со СПИД и инфекционными заболеваниями».
Россия

Шмагель Н.Г. – кандидат медицинских наук, врач-иммунолог ГКУЗ «Пермский краевой центр по борьбе со СПИД и инфекционными заболеваниями»; ФГБОУ ВПО «Пермский государственный национальный исследовательский университет».

г. Пермь.



В. А. Черешнев
ФГБОУ ВПО «Пермский государственный национальный исследовательский университет»; ФГБУН «Институт иммунологии и физиологии» УрО РАН.
Россия
Черешнев В.А. – доктор математических наук, академик РАН, директор ФГБУН «Институт иммунологии и физиологии» УрО РАН, г. Екатеринбург; ФГБОУ ВПО «Пермский государственный национальный исследовательский университет», г. Пермь.


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Для цитирования:


Шмагель К.В., Шмагель Н.Г., Черешнев В.А. АКТИВАЦИЯ ИММУНИТЕТА ПРИ ВИЧ-ИНФЕКЦИИ. Медицинская иммунология. 2017;19(5):489-504. https://doi.org/10.15789/1563-0625-2017-5-489-504

For citation:


Shmagel K.V., Shmagel N.G., Chereshnev V.A. IMMUNITY ACTIVATION IN HIV INFECTION. Medical Immunology (Russia). 2017;19(5):489-504. (In Russ.) https://doi.org/10.15789/1563-0625-2017-5-489-504

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