ТРИПТОФАН И INDOLEAMINE-2,3-DIOXYGENASE (IDO) В ПАТОГЕНЕЗЕ ИММУНОКОМПРОМЕТИРОВАННЫХ ЗАБОЛЕВАНИЙ
Аннотация
Резюме. Все больше и больше литературных данных свидетельствуют о ведущей роли в формировании иммуносупрессорных механизмов фермента indoleamin 2,3-deoxygenase (IDO), которая продуцируется в основном дендритными клетками, в индукции которой участвует в основном IFNγ и функции которой состоят в индукции катаболизма незаменимой аминокислоты триптофана. Уже одно снижение уровня триптофана в околоклеточной среде обуславливает подавление ряда функций клеток иммунной системы и индукцию регуляторных Т-клеток. Появление ряда катаболитов триптофана еще более усугубляет иммунодепрессивное состояние, индуцированное повышенной экспрессией IDO. Предполагается, что цепочка из IDO, триптофана и его катаболитов в значительной степени определяет формирование гиперсупрессорного состояния при опухолевом росте и гипо- (или недостаточного) супрессорного состояния при аутоиммунных и аллергических заболеваниях. Отсюда вытекают и новые задачи в терапии: найти способы терапии, направленные на снижение активности фермента IDO, участвующего в индукции клеток-супрессоров при опухолевом росте, и в то же время направленные на стимуляцию активности данного фермента для повышения супрессорной активности регуляторных клеток.
Об авторах
В. А. Козлов
ФГБНУ «Научно-исследовательский институт фундаментальной и клинической иммунологии», г. Новосибирск
Россия
д.м.н., профессор, академик РАН, научный руководитель
Россия
д.м.н., профессор, академик РАН, научный руководитель
Д. В. Демина
ФГБНУ «Научно-исследовательский институт фундаментальной и клинической иммунологии», г. Новосибирск
Россия
к.м.н., заведующая отделением аллергологии клиники иммунопатологии
Россия
к.м.н., заведующая отделением аллергологии клиники иммунопатологии
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Для цитирования:
Козлов В.А., Демина Д.В. ТРИПТОФАН И INDOLEAMINE-2,3-DIOXYGENASE (IDO) В ПАТОГЕНЕЗЕ ИММУНОКОМПРОМЕТИРОВАННЫХ ЗАБОЛЕВАНИЙ. Медицинская иммунология. 2017;19(3):225-240. https://doi.org/10.15789/1563-0625-2017-3-225-240
For citation:
Kozlov V.A., Demina D.V. TRYPTOPHAN AND INDOLEAMINE-2,3-DIOXYGENASE (IDO) IN PATHOGENESIS OF IMMUNOSUPPRESSIVE CLINICAL CONDITIONS. Medical Immunology (Russia). 2017;19(3):225-240. (In Russ.) https://doi.org/10.15789/1563-0625-2017-3-225-240
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