НОВЫЕ УЧАСТНИКИ НАРУШЕНИЯ ТОЛЕРАНТНОСТИ К АНТИГЕНАМ ЩИТОВИДНОЙ ЖЕЛЕЗЫ: К КОНЦЕПЦИИ ИММУНОПАТОГЕНЕЗА АУТОИММУННЫХ ЗАБОЛЕВАНИЙ ЩИТОВИДНОЙ ЖЕЛЕЗЫ (ОБЗОР ЛИТЕРАТУРЫ)
https://doi.org/10.15789/1563-0625-2016-3-209-220
Аннотация
Механизмы потери толерантности к аутоантигенам щитовидной железы до сих пор точно неизвестны, что не позволяет прояснить ключевые этапы патогенеза аутоиммунных заболеваний щитовидной железы и, следовательно, применить таргетные способы лечения этих заболеваний. Детальное изучение роли клеток врожденного и адаптивного иммунитета в нарушении толерантности к аутоантигенам щитовидной железы при болезни Грейвса и аутоиммунном тиреоидите прояснит и подготовит ряд теоретических основ для создания в перспективе клинико-иммунологического мониторинга и прогнозирования этих заболеваний.
Об авторах
В. В. ЗдорРоссия
к.м.н., научный сотрудник центральной научно-исследовательской лаборатории 690002, Россия, г. Владивосток, пр. Острякова, 4. Тел.: 8 (914) 791-96-25
Е. В. Маркелова
Россия
д.м.н., профессор, заведующая кафедрой нормальной и патологической физиологии
Б. И. Гельцер
Россия
д.м.н., профессор, член-корр. РАН, директор департамента фундаментальной и клинической медицины школы биомедицины Дальневосточного федерального университета и советник ректора по науке и инновациям
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Рецензия
Для цитирования:
Здор В.В., Маркелова Е.В., Гельцер Б.И. НОВЫЕ УЧАСТНИКИ НАРУШЕНИЯ ТОЛЕРАНТНОСТИ К АНТИГЕНАМ ЩИТОВИДНОЙ ЖЕЛЕЗЫ: К КОНЦЕПЦИИ ИММУНОПАТОГЕНЕЗА АУТОИММУННЫХ ЗАБОЛЕВАНИЙ ЩИТОВИДНОЙ ЖЕЛЕЗЫ (ОБЗОР ЛИТЕРАТУРЫ). Медицинская иммунология. 2016;18(3):209-220. https://doi.org/10.15789/1563-0625-2016-3-209-220
For citation:
Zdor V.V., Markelova E.V., Geltser B.I. NEW PLAYERS IN ALTERED TOLERANCE TO THYROID GLAND ANTIGENS: AN IMMUNOPATHOGENESIS CONCEPT OF AUTOIMMUNE THYROID DISEASE (REVIEW). Medical Immunology (Russia). 2016;18(3):209-220. (In Russ.) https://doi.org/10.15789/1563-0625-2016-3-209-220