CYTOKINES IN ANTERIOR EYE CHAMBER LIQUID: THEIR ROLE IN DEVELOPMENT OF SYSTEMIC IMMUNE RESPONSE TO OCULAR TISSUE ANTIGENS
https://doi.org/10.15789/1563-0625-2015-2-179-182
Abstract
The work is dedicated to studies of interrelations between the cytokine contents in the liquid from anterior eye chamber (AEC), and development of systemic immune response to ocular tissue antigens, described in terms of an anterior eye chamber-associated immune disturbance (ACAID phenomenon). The immune assays were conducted in parallel, using multiplex cytokine analysis (flow cytometry technique), and leukocyte inhibition migration reaction. Twenty-six patients with different forms of ophthalmic pathology were examined, including cases of uveitis (18), keratouveitis (3), glaucoma (5). It is shown that the reduced TGF-β1 levels and increased concentrations of proinflammatory, chemotactic cytokines in AEC liquid are associated with development of organ-specific immune sensitization.
About the Authors
I. G. Kulikova
The Moscow Helmholtz Research Institute of Eye Diseases 105062, Russian Federation, Moscow, Sadovaya- Chernogryazskaya str., 14/19.
Russian Federation
Russian Federation
Senior Research Associate, Laboratory of Immunology and Virology, The Moscow Helmholtz Research Institute of Eye Diseases, Moscow, Russian Federation
O. S. Slepova
The Moscow Helmholtz Research Institute of Eye Diseases 105062, Russian Federation, Moscow, Sadovaya- Chernogryazskaya str., 14/19.
Russian Federation
Russian Federation
PhD, MD (Biology), Professor, Head, Laboratory of Virology and Immunology, The Moscow Helmholtz Research Institute of Eye Diseases, Moscow, Russian Federation
E. V. Denisova
The Moscow Helmholtz Research Institute of Eye Diseases 105062, Russian Federation, Moscow, Sadovaya- Chernogryazskaya str., 14/19.
Russian Federation
Russian Federation
PhD (Medicine), Senior Research Associate, Department of Pediatric Ocular Pathology, The Moscow Helmholtz Research Institute of Eye Diseases, Moscow, Russian Federation
L. A. Kovaleva
The Moscow Helmholtz Research Institute of Eye Diseases 105062, Russian Federation, Moscow, Sadovaya- Chernogryazskaya str., 14/19.
Russian Federation
Russian Federation
Research Associate, Department of Infectious and Allergic Eye Diseases, The Moscow Helmholtz Research Institute of Eye Diseases, Moscow, Russian Federation
P. V. Makarov
The Moscow Helmholtz Research Institute of Eye Diseases 105062, Russian Federation, Moscow, Sadovaya- Chernogryazskaya str., 14/19.
Russian Federation
Russian Federation
PhD, MD (Medicine), Senior Research Associate, Department of Traumatology, Reconstructive Plastic Surgery and Ocular Prosthetics, The Moscow Helmholtz Research Institute of Eye Diseases, Moscow, Russian Federation
D. N. Lovpache
The Moscow Helmholtz Research Institute of Eye Diseases 105062, Russian Federation, Moscow, Sadovaya- Chernogryazskaya str., 14/19.
Russian Federation
Russian Federation
PhD (Medicine), Research Associate, Department of Glaucome, The Moscow Helmholtz Research Institute of Eye Diseases, Moscow, Russian Federation
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Review
For citations:
Kulikova I.G., Slepova O.S., Denisova E.V., Kovaleva L.A., Makarov P.V., Lovpache D.N. CYTOKINES IN ANTERIOR EYE CHAMBER LIQUID: THEIR ROLE IN DEVELOPMENT OF SYSTEMIC IMMUNE RESPONSE TO OCULAR TISSUE ANTIGENS. Medical Immunology (Russia). 2015;17(2):179-182. (In Russ.) https://doi.org/10.15789/1563-0625-2015-2-179-182
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