STUDIES ON THE ROLE OF CYTOKINES POLYMORPHISM IN PATHOGENESIS OF CHRONIC URTICARIA
https://doi.org/10.15789/1563-0625-2015-2-167-172
Abstract
Fifty patients with chronic autoimmune urticaria (CAU) and forty-eight patients with chronic idiopathic urticaria (CIU) have been examined. Blood serum contents of IL-4, IL-10 and IL-17A, spontaneous and induced cytokine production in blood cells, as well as polymorphism of IL-4 (C-589T), IL-10 (G-1082A), IL-17A (G-197A) cytokine genes has been studied. No differences have been detected when studying IL-4 levels, depending on genetic variants of IL-4 gene in patients with CAU and CIU. Increased IL-10 amounts in patients with CIU still did not show any correlations with IL-10 genotype (G-1082A). Increased IL-17A levels in patients with CAU were associated with homozygous genotype of AA in comparison to control group, and with heterozygous GA genotype, in comparison to CIU group. The revealed differences of cytokines` genes polymorphism in CAU and CIU provide a molecular-genetic evidence for different clinical forms of chronic urticaria.
About the Authors
N. I. Baranova
Penza Institute of Postgraduate Medical Education 440060, Russian Federation, Penza, Stasova str., 8a.
Russian Federation
Russian Federation
PhD, MD (Biology), Associate Professor, Head, Central Research Laboratory, Penza Institute of Postgraduate Medical Education, Penza, Russian Federation
O. A. Levashova
Penza Institute of Postgraduate Medical Education 440060, Russian Federation, Penza, Stasova str., 8a.
Russian Federation
Russian Federation
PhD (Biology), Associate Professor, Senior Research Associate, Central Research Laboratory, Penza Institute of Postgraduate Medical Education, Penza, Russian Federation
S. V. Kozhenkova
Penza Institute of Postgraduate Medical Education 440060, Russian Federation, Penza, Stasova str., 8a.
Russian Federation
Russian Federation
PhD Fellow, Department of Allergology and Immunology, Penza Institute of Postgraduate Medical Education, Penza, Russian Federation
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Review
For citations:
Baranova N.I., Levashova O.A., Kozhenkova S.V. STUDIES ON THE ROLE OF CYTOKINES POLYMORPHISM IN PATHOGENESIS OF CHRONIC URTICARIA. Medical Immunology (Russia). 2015;17(2):167-172. (In Russ.) https://doi.org/10.15789/1563-0625-2015-2-167-172
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