АMINO ACID BALANCE PLASMA AND MONOCYTES IN PATIENTS WITH TUBERCULOSIS AS A FACTOR, REFLECTS THE SEVERITY OF DEVELOPMENT OF TUBERCULOSIS
https://doi.org/10.15789/1563-0625-2015-1-75-80
Abstract
The study included 90 patients with pulmonary tuberculosis who were divided into 3 groups, according to intensity and clinical form of the disease. Group 1 included 32 patients with infiltrative tuberculosis and two-segment pulmonary lesions; group 2, 31 patients with pulmonary tuberculoma, and group 3, 27 patients with fibrous/cavernous tuberculosis for less than two years after the process stabilization. Group 4 represented a control (comparison) group of 30 healthy volunteers. The analysis showed that amino acid balance of monocytes in pulmonary tuberculosis can be, in general, characterized as deficient for antioxidant resources. In case of tuberculous inflammation, the criteria of specific resistance comprise a necessary taurine pool to greater extent than glutathione oxidation in immunocompetent cells. The plasma/monocyte taurine ratios exhibit different values, depending on clinical form of pulmonary tuberculosis. Redistribution of plasma amino acids to the monocytes, or, vice versa, probable “washout” certain amino acids from the cells may be considered a factor that reflects severity of the infectious process.
About the Authors
S. N. Skorniakov
Ural Research Institute of Phthysiopneumology, Russian Ministry of Health Care
620039, Russian Federation, Ekaterinburg, 22-go Partsyezda str., 50.
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, Director, Ural Research Institute of Phthysiopneumology, Russian Ministry of Health Care, Ekaterinburg, Russian Federation
E. V. Sabadash
Ural Research Institute of Phthysiopneumology, Russian Ministry of Health Care
620039, Russian Federation, Ekaterinburg, 22-go Partsyezda str., 50.
Russian Federation
Russian Federation
PhD (Medicine), Senior Research Associate, Ural Research Institute of Phthysiopneumology, Russian Ministry of Health Care, Ekaterinburg, Russian Federation
I. D. Medvinsky
Ural Research Institute of Phthysiopneumology, Russian Ministry of Health Care
620039, Russian Federation, Ekaterinburg, 22-go Partsyezda str., 50.
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, Deputy Director for Research, Ural Research Institute of Phthysiopneumology, Russian Ministry of Health Care, Ekaterinburg, Russian Federation
B. I. Novikov
Ural Research Institute of Phthysiopneumology, Russian Ministry of Health Care
620039, Russian Federation, Ekaterinburg, 22-go Partsyezda str., 50.
Russian Federation
Russian Federation
PhD (Medicine), Senior Research Associate, Head of the Center of Extrapulmonary Tuberculosis, Ural Research Institute of Phthysiopneumology, Russian Ministry of Health Care, Ekaterinburg, Russian Federation
V. A. Pavlov
Ural Research Institute of Phthysiopneumology, Russian Ministry of Health Care
620039, Russian Federation, Ekaterinburg, 22-go Partsyezda str., 50.
Russian Federation
Russian Federation
PhD, MD (Medicine), Leading Research Associate, Ural Research Institute of Phthysiopneumology, Russian Ministry of Health Care, Ekaterinburg, Russian Federation
References
1. Авербах М.М. Туберкулезная гранулема. Современный взгляд на иммуногенез и клеточный состав // Туберкулез и болезни легких, 2010. No 6. С. 3-9. [Averbach M.М. Tuberculous granulomas. The modern view on immunogenesis and cellular composition .Tuberkulez i bolezni legkikh = Tuberculosis and Lung Disease, 2010, no. 6, pp. 3-9. (In Russ.)]
2. Александрова А.Е. Место средств патогенетической направленности действия в терапии туберкулеза // Патогенетическая терапия легочного и внелегочного туберкулеза. Л., 1987. С. 11-18. [Alexandrova A.E. Place of the pathogenetic orientation of action in the treatment of tuberculosis. Pathogenetic therapy of pulmonary and еxtrapulmonary tuberculosis]. Leningrad, 1987, pp 11-18 .
3. Белокрылов Г.А., Молчанова И.М., Сорочинская Е.И., Хаитов Р.Б., Пинегин Б.В., Исламов Х.И. Аминокислоты как стимуляторы иммуногенеза // Экологическая иммунология. М.: ВНИРО, 1995. 219 с. [Belokrylov G.A., Molchanova I.M., Sorochinskaya E.I., Khaitov R.B., Pinegin B.V., Islamov H.I. Amino acids as stimulants immunogenesis. Ecological immunology]. Moscow: VNIRO, 1995. 219 р.
4. Брудастов Ю.А., Журлов О.С., Грудинин Д.А. Активные метаболиты кислорода при фагоцитозе // Вестник ОГУ, 2008. No 12. С. 148-151. [Brudastov Y.A., Zhurlov O.S., Grudinin D.A. Active oxygen metabolites during phagocytosis. Vestnik OGU = Bulletin OSU. 2008, no. 12, pp. 148-151. (In Russ.)]
5. Бубочкин Б.П., Ратников В.И., Потапов И.В. Характеристика нитроксидергического профиля у впервые заболевших очаговым и инфильтративным туберкулезом легких // Тез. докладов 4 съезда науч.мед. ассоциации фтизиатров. М.: Йошкар-Ола, 1999. С. 15-19. [Bubochkin B.P., Ratnikov V.I., Potapov I.V. Feature nitroksidergicheskogo profile in newly diagnosed focal and infiltrative pulmonary tuberculosis // Proc. 4 Reports the Congress Scientific Medical Association of Phthisiologists]. Moscow: Yoshkar-Ola, 1999, pp. 15-19. (In Russ.)]
6. Волков М.С., Генкин А.М., Глотов Н.А. Глутаминовая кислота. Биохимические механизмы практического использования. Свердловск, 1975. 225 с. [Volkov M.S., Genkin A.В. Swallowing N.A. Glutamic acid. Biochemical mechanisms of practical use]. Sverdlovsk, 1975. 225 р.
7. Гончаров А.Е. Функциональная характеристика моноцитарных дендритных клеток больных туберкулезом легких // Докл. НАН Беларуси, 2008. Т. 52, No 1. С. 92-96. [Goncharov A.E. Functional characterization of monocyte-derived dendritic cells of patients with pulmonary tuberculosis // Report NASB, 2008, Vol. 52, no. 1, pp. 92-96. (In Russ.)]
8. Игнатьева Г.А. Современные представления об иммунитете (контуры общей теории) // Патофизиология и экспериментальная терапия, 2003. No 2. С. 2-7. [Ignatieff G.A. Modern concepts of immunity (contours of the general theory). Patofiziologiya i eksperimental`naya terapiya = Pathophysiology and Experimental Therapy. 2003, no. 2, pp. 2-7. (In Russ.)]
9. Гаркави Л.Х., Квакина Е.Б., Уколова М.А. Адаптационные реакции и резистентность организма. Ростов-на-Дону: Из-во Ростовского университета, 1990. 224 с. [Garkavi L.H., Kvakina E.B., Ukolov M.A. Adaptive response and resistance]. Rostov-on-Don: Publisher of Rostov University, 1990. 224 p.
10. Еремеев В.В., Майоров К.Б. Взаимодействие макрофаг-микобактерия, в процессе реакции микроорганизма на туберкулезную инфекцию // Проблемы туберкулеза, 2002. No 3. С. 54-56. [Eremeyev V.V., Mayorov K.B. Interaction macrophag-mycobacterium, during the reaction microorganism to TB infection. Problemy tuberkuleza = Problems of Tuberculоsis, 2002, no. 3, pp. 54-56. (In Russ.)]
11. Западнюк В.И., Купраш Л.И., Заика Л.У. Аминокислоты в медицине. Киев: Здоров’я, 1982. С. 58-63. [Zapadnyuk V.I., Kuprash L.I., Zaika L.U. Amino acids in medicine]. Kiev: Health, 1982, pp. 58-63.
12. Криворученко Н.С. Содержание соединений серы в моче у больных туберкулезом легких //Проблемы туберкулеза, 1984. No 11. С. 64-66. [Krivoruchenko N.S. Content of sulfur compounds in the urine of patients with pulmonary tuberculosis. Problemy tuberkuleza = Problems of Tuberculosis, 1984, no. 11, pp. 64-66. (In Russ.)]
13. Кричевская А.А., Шугалей В.С., Цветненко Е.З. Аргиназа и полиамины мозга и печени в механизме защитного действия аргинина при гипероксии // Бюлл. экспер. биол. и мед., 1981. Т. 91, No 4. С. 445-447. [Krichevskaya A.A., Shugaley V.S., Tsvetnenko E.Z. Arginase and polyamines of the brain and liver in the mechanism of the protective action of arginine with hyperoxia. Byullen` eksperimental`noy biologii i meditsiny = Bulletin of Experimental Biology and Medicine, 1981, no. 4, pp. 445-447. (In.Russ.)]
14. Маянский А.Н. Туберкулез (микробиологические и иммунопатогенетические аспекты) // Иммунология, 2001. No 2. С. 53-63. [Mayansky A.N. Tuberculosis (microbiological and immunopathogenetic aspects). Immunologiya = Immunology, 2001, no. 2, pp. 53-63. (In Russ.)]
15. Павлов В.А., Медвинский И.Д., Чугаев Ю.П., Сабадаш Е.В. Защитно-адаптивные механизмы при туберкулезной инфекции // Фтизиатрия и пульмонология, 2011. No 1. С. 42-54. [Pavlov V.A., Medvinsky I.D., Chugai Y.P., Sabadash E.V. Protective and adaptive mechanisms in tuberculosis infection. Ftiziatriya i pul`monologiya = Phthisiology and Pulmonology, 2011, no. 1, pp. 42-54. (In Russ.)]
16. Сахно Л. В., Черных Е.Р. Антигенпрезентирующие клетки при туберкулезе легких //Туберкулез и болезни легких, 2012. No 1. С. 3-9. [Sahno L.V., Chernykh E.R. Antigen-presenting cells in pulmonary tuberculosis. Tuberkulez i bolezni legkikh = Tuberculosis and Lung Disease, 2012, no. 1, pp. 3-9. (In Russ.)]
17. Сахно Л.В., Тихонова М.А., Кожевников В.С. Фенотипическая и функциональная характеристика моноцитов у больных туберкулезом легких // Медицинская иммунология, 2005. Т. 7, No 1. С. 49-56. [Sahno L.V., Tikhonova M.A., Kozhevnikov V.S. Phenotypic and functional characteristics of monocytes in patients with pulmonary tuberculosis. Meditsinskaya immunologiya = Medical Immunology (Russia), 2005, Vol. 7, no. 1. pp. 49-56. (In Russ.)]
18. Струков А.И., Соловьева И.П. Морфология туберкулеза в современных условиях. М.: Медицина, 1986. 232 с. [Strukov A.I., Solovyovа I.P. Morphology of tuberculosis in modern conditions]. Moscow: Medicine, 1986. 232 р.
19. Шатаева Л.К., Хавинсон В.Х., Ряднова И.Ю. Пептидная саморегуляция (факты и гипотезы). СПб.: Наука, 2003. 210 с. [Shataeva L.K., Havinson V.H., Ryadnova I.Y. Peptide self-regulation (facts and hypotheses)]. St. Petersburg: Science, 2003. 210 p.
20. Ярилин А.А. Иммунология. М.: ГЭОТАР-Медиа, 2010. 752 c. [Yarilin A.A. Immunology]. Moscow: GEOTAR-Media, 2010. 752 р.
21. Amano F., Noda T. Improved detection of nitric oxide radical (NO•) production in an activated macrophage culture with a radical scavenger, carry PTIO, and Griess reagent. FEBS Let., 1995, Vol. 368, pp. 425-428.
22. Fenton M.J., Vermilion M.W. Immunopathology of tuberculosis role of macrophages and monocytes. Infect. Immun., 1996, Vol. 4, pp. 683-690.
23. Galan A.I., Minoz M.E., Palomero J., Moreno C., Jimenez R. Role of S-adenosylme-thionine on the hepatobiliary homeostasis of glutathione during cyclosporine a treatment. J. Physiol. Biochem., 2000, no. 56, pp. 189-200.
24. North R.J., Jung Y.J. Immunity to tuberculosis. Annual Review of Immunology, 2004, Vol. 22, pp. 599-623.
25. Pereira C.B., Palace M., Leyte O.H., Duarte A.J., Benard G. Monocyte cytokine secretion in patients with pulmonary tuberculosis differs from that of healthy infected subjects and correlates with clinical manifestations. Microbes and Infection, 2004, pp. 25-33.
26. Saton H., Kang J. Modulation by taurine of human arterial stiffness and wave reflection. Adv. Exp. Med. Biol., 2009, Vol. 643, pp. 47-55.
Review
For citations:
Skorniakov S.N., Sabadash E.V., Medvinsky I.D., Novikov B.I., Pavlov V.A. АMINO ACID BALANCE PLASMA AND MONOCYTES IN PATIENTS WITH TUBERCULOSIS AS A FACTOR, REFLECTS THE SEVERITY OF DEVELOPMENT OF TUBERCULOSIS. Medical Immunology (Russia). 2015;17(1):75-80. (In Russ.) https://doi.org/10.15789/1563-0625-2015-1-75-80
Views:
1434
Email this article 