FEATURES OF IMMUNE RESPONSE AND BASOPHIL ACTIVATION IN CHILDREN WITH CHRONIC URTICARIA
https://doi.org/10.15789/1563-0625-2015-1-39-46
Abstract
Some features of peripheral bood basophil activation were studied in children with different types of chronic urticaria, in order to specify the sustaining mechanisms of chronic urticaria. This study presents comparative data concerning spontaneous basophil activation, IgE level and Th2 helper cells. We observed forty-seven children with chronic urticaria, seventy children with exacerbated atopic dermatitis with different disease severity, fifteen healthy children without signs of allergy, or pseudo-allergy. High degree of the basophil activation was detected in children with exacerbation of atopic dermatitis (a comparison group), which was different from the groups of healthy children and patients with chronic urticaria. Spontaneous basophile activation was higher in children with chronic urticaria than in healthy children, as influenced by immune and non-immune pathogenetic factors of the disease. A positive pairwise correlation was shown between total IgE level, and Th2 helper cell numbers in peripheral blood in patients with chronic urticaria, thus confirming a Th2 immune shift. The results obtained contribute to our understanding of immune pathology in chronic urticaria.
About the Authors
N. A. Sinelnikova
St. Petersburg State Pediatric Medical University
198097, Russian Federation, St. Petersburg, Stachek pr., 32-42.
Russian Federation
Russian Federation
PhD Candidate, Department of Faculty Pediatrics, St. Petersburg State Pediatric Medical University, , St. Petersburg, Russian Federation
N. V. Bychkova
All-Russian Center of Extremal and Radiation Medicine, Russian Ministry of Extreme Situations, St. Petersburg, Russian Federation
Russian Federation
Russian Federation
PhD (Biology), Senior Research Associate, Laboratory of Clinical Immunology, All-Russian Center
of Extremal and Radiation Medicine, Russian Ministry
of Extreme Situations, St. Petersburg, Russian Federation
N. M. Kalinina
All-Russian Center of Extremal and Radiation Medicine, Russian Ministry of Extreme Situations, St. Petersburg, Russian Federation
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, Head, Research Department of Clinical Immunology, All-Russian Center of Extremal and Radiation Medicine, Russian Ministry of Extreme Situations, St. Petersburg, Russian Federation
References
1. Church M.K., Weller K., Stock P., Maurer M. Chronic spontaneous urticaria in children: Itching for insight. Pediatric Allergy and Immunology, 2011, Vol. 22, pp. 1-8.
2. Siracusa M.C., Kim B.S., Spergel J.M., Artis D. Basophils and allergic inflammation Glossary. Journal of Allergy and Clinical Immunology, 2013, Vol. 132, pp. 789-801.
3. Konstantinou G.N., Asero R., Ferrer M., Knol E.F., Maurer M., Raap U., Schmid-Grendelmeier P., Skol P. S., Grattan C. E. H. EAACI taskforce position paper: evidence for autoimmune urticaria and proposal for defining diagnostic criteria. Allergy, 2013, Vol. 68, pp. 27-36.
4. Kang M.G., Song W.J., Park H.K., Lim K.H., Kim S.J., Lee S.Y., Kim S.H., Cho S.H., Min K.U., Chang Y.S. Basophil Activation Test with Food Additives in Chronic Urticaria Patients. Clinical Nutrition Research, 2014, Vol. 3, pp. 9-16.
5. Gao J., Yang A., Chen M., Li A., Yao X., Li Y., Xie S., Yang X., Zhong L., Chen Z. mRNA profiles of cytokine receptors in unstimulated peripheral blood mononuclear cells from patients with chronic idiopathic urticaria. The Journal of Biomedical Research, 2011, Vol. 25, pp. 141-147.
6. Santos J.C., de Brito C.A., Futata E.A., Azor M.H., Orii N.M., Maruta C.W., Rivitti E.A., Duarte A.J.S., Sato M.N. Up-regulation of chemokine C–C ligand 2 (CCL2) and C-X-C chemokine 8 (CXCL8) expression by monocytes in chronic idiopathic urticaria. Clinical and Experimental Immunology, 2012, Vol. 167, pp. 129-136.
7. Maurer M., Magerl M., Metz M., Zuberbier T. Revisions to the international guidelines on the diagnosis and therapy of chronic urticaria. Journal der Deutschen Dermatologischen Gesellschaft, 2013, Vol. 11, pp. 971-978.
8. Machura E., Jońska-Golus M., Krakowczyk H., Kasperska-Zając A., Ziora K. Etiology and clinical course of urticaria in hospitalized children. Med Wieku Rozwoj, 2013, Vol. 17, pp. 64-71.
9. Sand F.L., Thomsen S.F.. TNF-Alpha Inhibitors for Chronic Urticaria: Experience in 20 Patients. Journal of Allergology, 2013, Vol. 2013, pp. 1-4.
10. Grattan C.E.H., Sabroe R.A., Greaves M.W. Chronic urticaria. Journal of the American Academy of Dermatology, 2002, Vol. 46, pp. 645-657.
Review
For citations:
Sinelnikova N.A., Bychkova N.V., Kalinina N.M. FEATURES OF IMMUNE RESPONSE AND BASOPHIL ACTIVATION IN CHILDREN WITH CHRONIC URTICARIA. Medical Immunology (Russia). 2015;17(1):39-46. (In Russ.) https://doi.org/10.15789/1563-0625-2015-1-39-46
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