ROLE OF CYTOKINE PRODUCTION DISORDERS IN GENESIS OF PLACENTAL INSUFFICIENCY AND EARLY REPRODUCTIVE LOSSES

Abstract

We have analyzed clinical and laboratory data for 256 women surveyed in early pregnancy, being later classified by their pregnancy outcomes, i.e., placental insufficiency (n=106), interruption in the first trimester (n = 38) and uncomplicated cases with delivery of live, full-term infants (n = 112). We evaluated serum levels of cytokines and their soluble receptors, as well as spontaneous and induced cytokine production by whole blood cells and intracellular synthesis of IFNг and IL-4 by the T-helpers from peripheral blood. It was shown that the cases complicated with subsequent compensated placental insufficiency are associated with activation of mitogen-induced cellular production of IL-1в, whereas development of subcompensated placental insufficiency is associated with increased serum levels of IL-1в and IL-1ra at early terms of gestation. An increased mitogen-induced synthesis of IFNг in blood cells represents a common risk factor for subcompensated placental insufficiency and miscarriage in the first trimester of gestation. Along with elevated mitogen-induced interferonogenesis, cellular overproduction of IL-2, as well as increased intracellular synthesis of IFNг and IL-4 by T-helpers under additional stimulation, accompanied by a growing polarization of Th1/Th2 are predictive for early reproductive losses.