IMMUNOPROTEOMICS OF INFECTIOUS ENDOCARDITIS OF NATIVE HEARTVALVES
https://doi.org/10.15789/1563-0625-2008-1-27-34
Abstract
Abstract. The aim of present study was to analyze the most commonly detected blood plasma immune proteins, that reflect molecular pathways in development of infectious endocarditis of native valves, together with analysis of marker proteins of disease on the base of modern technological platform for clinical proteomics. Ninety-nine patients with infectious endocarditis of native heart valves were included into the study. All the patients were examined according to hospital assessment protocol, including clinical, laboratory and instrumental methods of evaluation. Separation and identification of proteins of microorganisms in blood and materials taken at surgery, detection of proteins related to functioning of immune system, were carried out using new methods of clinical proteomics. We have revealed same proteins, that are specific of pathogens causing infectious endocarditis, that thus representing immunogenic determinants and defining a systemic immune response in the patients.
About the Authors
A. A. Rumbesht
Государственное учреждение здравоохранения «Ростовская областная клиническая больница», г. Ростов-на-Дону
Russian Federation
Russian Federation
A. E. Matsionis
Государственное учреждение здравоохранения «Ростовская областная клиническая больница», г. Ростов-на-Дону
Russian Federation
Russian Federation
A. A. Dyuzhikov
Государственное учреждение здравоохранения «Ростовская областная клиническая больница», г. Ростов-на-Дону
Russian Federation
Russian Federation
I. V. Sarvilina
Южный научный центр Российской академии наук, г. Ростов-на-Дону
Russian Federation
Russian Federation
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Review
For citations:
Rumbesht A.A., Matsionis A.E., Dyuzhikov A.A., Sarvilina I.V. IMMUNOPROTEOMICS OF INFECTIOUS ENDOCARDITIS OF NATIVE HEARTVALVES. Medical Immunology (Russia). 2008;10(1):27-34. (In Russ.) https://doi.org/10.15789/1563-0625-2008-1-27-34
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