COMPARATIVE EVALUATION OF CHRONIC RECURRENT FURUNCULOSIS AND PHAGOCYTIC COMPONENT OF IMMUNITY AMONG PATIENTS DIFFERING IN IgE LEVELS
https://doi.org/10.15789/1563-0625-2014-3-295-300
Abstract
The aim of this work was to compare clinical features of severity and some basic indicators of immune state in the patients with chronic recurrent furunculosis (CRF), differing in levels of serum immunoglobulin E (IgE). In cases with increased IgE levels, the clinical course proved to be more severe, as characterized by persistent recurrence of infection, with multiple lesions and weak inflammatory reaction, as compared with patients with normal IgE levels. Meanwhile, additional purulent skin lesions were less common among patients from this group. Comparative evaluation of basic anti-pyogenic defense effects allowed us to show a significant decrease of induced chemiluminescence of whole heparinized blood (p < 0.05) in patients with increased IgE levels, thus regarding it as a potential factor of more severe CRF clinical course in this cohort of patients.
About the Authors
T. A. Druzhinina
Penza Institute of Postgraduate Education, Russian Ministry of Health Care, Penza
Russian Federation
PhD (Biology), Senior Research Associate, Penza Institute of Postgraduate Education, Russian Ministry of Health Care
Russian Federation
PhD (Biology), Senior Research Associate, Penza Institute of Postgraduate Education, Russian Ministry of Health Care
N. Yu. Alekseeva
Penza Institute of Postgraduate Education, Russian Ministry of Health Care, Penza
Russian Federation
Russian Federation
PhD (Medicine), Assistant Professor, Allergology and Immunology Department, Penza Institute of Postgraduate Education, Russian Ministry of Health Care
References
1. Belykh O.A., Levchin N.K. Soderzhanie IgE v krovi patsientov dermatologicheskoy kliniki. Materialy ob'edinennogo immunologicheskogo forum [Content of IgE in the blood of the patients of dermatological clinic (The materials of the united immunological forum)]. Ekaterinburg, 2004, p. 102.
2. Gostishchev V.K. Infektsii v khirurgii: Rukovodstvo dlya vrachey [Infections in the surgery: Management for the doctors]. Moscow, GEOTAR-Media, 2007. 768 p.
3. Druzhinina T.A., Levashova O.A. Sposob opredeleniya rezerva reaktivnosti neytrofilov (oksidantnogo potentsiala) [Method of determining the reserve of the reactivity of neutrophils (oxidant potential)]. Patent forthe Invention of RF N 2457488.
4. Zheleznikova G.F. Immunoglobulin E: biologicheskaya rol` pri infektsionnykh zabolevaniyakh [Immunoglobulin E: Biological role with the infectious diseases]. Meditsinskaya immunologiya – Medical Immunology, 2002, no. 4-5, pp. 515-534.
5. Man`ko K.S. Differentsirovannyy podkhod k naznacheniyu sinteticheskikh immunoregulyatornykh peptidov v sostave kompleksnoy terapii khronicheskogo retsidiviruyushchego furunkuleza: Avtoref. diss. … kand. med. nauk [Individual approach to the designation of synthetic immunoregulator peptide in the composition of the complex therapy of the chronic relapsing furunculosis. Autoref. Cand. med. sci. diss.]. Moscow, 2006, p. 54.
6. Savitskaya L.N. Kliniko-immunologicheskie osobennosti patogeneza, techeniya, terapii furunkuleza v Kazakhstane (kliniko-eksperimental`noe issledovanie): Avtoref. diss. … dokt. med. nauk [Clinicoimmunological special features of pathogenesis, flow, therapy of furunculosis in Kazakhstan (clinicalexperimental study): Autoref. Doct. med. sci. diss.]. Semipalatinsk, 1987.
7. Setdikova N.H., Latysheva T.V. Kompleksnye mekhanizmy razvitiya khronicheskogo retsidiviruyushchego furunkuleza i puti ikh korrektsii [Complex mechanisms underlying chronic recurrent furunculosis and methods of their correction]. Immunologiya – Immunology, 2000, no. 3, pp. 48-58.
8. Fedorov G.N., Leonov S.D. Osobennosti khemilyuminestsentsii tsel`noy razvedennoy krovi [Special features of the chemiluminescence of whole separated blood]. Elektronnyy matematicheskiy i medikobiologicheskiy zhurnal – Electronic Mathematical and Biomedical Periodical, 2007, vol. 6, no. 4.
9. Yaglova N.V. Tuchnye kletki i vrozhdennyy immunitet [Fat cells and the innate immunity]. Immunologiya – Immunology, 2009, no. 2, pp. 139-189.
10. Ito S., Shinomiya K., Mikawa H. Suppressive effect of IgE soluble immune complex on neutrophils chemotaxis. Clin. Exp. Immunol., 1983, vol. 51, no. 2, pp. 407-412.
11. Laube S. Skin infections and ageing. Ageing Res. Rev., 2004, no. 3, pp. 69-89.
12. Truong M.J., Gruart V., Kusnierz J.P., Papin J.P., Loiseau S., Capron A.,Capron M. Human neutrophyls express immunoglobulin E (IgE)-binding proteins (Mac-2/epsilon BP) of the S-type lectin family: role in IgE-dependent activation. J. Exp. Med., 1993, vol. 177, pp. 243-248.
Review
For citations:
Druzhinina T.A., Alekseeva N.Yu. COMPARATIVE EVALUATION OF CHRONIC RECURRENT FURUNCULOSIS AND PHAGOCYTIC COMPONENT OF IMMUNITY AMONG PATIENTS DIFFERING IN IgE LEVELS. Medical Immunology (Russia). 2014;16(3):295-300. (In Russ.) https://doi.org/10.15789/1563-0625-2014-3-295-300
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