LONG-TERM CHANGES OF INFLAMMATION MARKERS IN PATIENTS WITH NON-ST ELEVATION ACUTE CORONARY SYNDROME FOLLOWING CORONARY ARTERY BYPASS GRAFTING SURGERY
https://doi.org/10.15789/1563-0625-2014-2-183-188
Abstract
It was found that soluble intercellular adhesion molecule-1 (ICAM-1) and leukocyte levels in patients with non-ST elevation acute coronary syndrome exhibited a gradual decrease during follow-up period of 6 to 12 months after CABG, as compared with pre-treatment baseline rates. In addition, sICAM-1 level showed an increase at 48 month post-CABG, tending to pre-treatment values. The levels of tumor necrosis factor-alpha (TNFa) and interleukin-6 (IL-6) did not express any significant changes during the entire observation period. TNFα level in the patients with non-STEMI before surgery did not differ from the levels in the patients with stable ischemic heart disease (60.0±9.8 pg/ml and 51.0±6.8 pg/ml; p > 0.05). Serum TNFα level remained unchanged in the patients after CABG. Similar changes were found for IL-6, with no differences between initial levels in the patients with non-STEMI and those with stable coronary artery disease (34.5±3.6 pg/ml and 28.6±3.1 pg/ml; p > 0.05). The IL-6 levels remained virtually unchanged over the observation time. Therefore, the ambiguous results obtained in present study deserve further studies of the role of inflammatory mediators in different clinical forms of ischemic heart disease following CABG.
About the Authors
N. A. Gavricheva
St. Petersburg I. Pavlov State Medical University, St. Petersburg
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, Department of Pathophysiology with a Course of Clinical Pathological Physiology, St. Petersburg I. Pavlov State Medical University
K. V. Korzhenevskaya
Almazov Federal Center of Heart, Blood, and Endocrinology, St. Petersburg
Russian Federation
Russian Federation
PhD (Medicine), Senior Research Associate, Almazov Federal Center of Heart Blood, and Endocrinology
G. V. Alekseeva
St. Petersburg I. Pavlov State Medical University, St. Petersburg
Russian Federation
Russian Federation
PhD (Medicine), Researche Associate, St. Petersburg I. Pavlov State Medical University
A. V. Panov
Almazov Federal Center of Heart, Blood, and Endocrinology, St. Petersburg
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, Almazov Federal Heart Blood and Endocrinology Center
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For citations:
Gavricheva N.A., Korzhenevskaya K.V., Alekseeva G.V., Panov A.V. LONG-TERM CHANGES OF INFLAMMATION MARKERS IN PATIENTS WITH NON-ST ELEVATION ACUTE CORONARY SYNDROME FOLLOWING CORONARY ARTERY BYPASS GRAFTING SURGERY. Medical Immunology (Russia). 2014;16(2):183-188. (In Russ.) https://doi.org/10.15789/1563-0625-2014-2-183-188
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