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Медицинская иммунология

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ИММУНОПАТОГЕНЕЗ ПСОРИАЗА И ПСОРИАТИЧЕСКОГО АРТРИТА

https://doi.org/10.15789/1563-0625-2014-2-127-138

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Аннотация

Актуальность изучения псориаза (ПС) обусловлена ростом заболеваемости, учащением случаев тяжелых форм, таких как псориатический артрит (ПсА). Клиника и исход псориаза и псориатического артрита во многом зависят от степени иммунологических нарушений и дисбаланса цитокиновой регуляции межклеточных взаимодействий. В иммунопатогенезе ПС и ПсА ведущими являются иммунные нарушения, характеризующиеся девиацией цитокинового профиля по Th1-типу (TNFα, IL-2, IFNγ и др.). Проведен анализ данных литературы, раскрывающих особенности иммунопатогенеза ПС и ПсА в ассоциации с характером течения патологического процесса. Привлечено внимание к относительно новым и малоизученным данным о роли цитокинов, продуцируемых Th17- и Th22-клетками (IL-17, IL-22, IL-23, IL-26), подсемейства цитокинов IL-19 (IL-19, IL-20 и IL-24) в патогенезе ПС и ПсА. Поиск иммунологических маркеров риска развития ПС и ПсА является важным шагом персонализированного подхода к прогнозу их течения и формированию профилактических мероприятий с целью предупреждения прогрессирования патологии.

Об авторах

С. В. Смирнова
ФГБУ «Научно-исследовательский институт медицинских проблем Севера» СО РАМН, г. Красноярск
Россия

профессор, заместитель директора по научной работе, руководитель отдела клинической иммунологии и клеточных технологий ФГБУ «Научно-исследовательский институт медицинских проблем Севера» СО РАМН



М. В. Смольникова
ФГБУ «Научно-исследовательский институт медицинских проблем Севера» СО РАМН, г. Красноярск
Россия

к.б.н., ведущий научный сотрудник, лаборатория клеточно-молекулярной физиологии и патологии ФГБУ «Научно-исследовательский институт медицинских проблем Севера» СО РАМН



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Для цитирования:


Смирнова С.В., Смольникова М.В. ИММУНОПАТОГЕНЕЗ ПСОРИАЗА И ПСОРИАТИЧЕСКОГО АРТРИТА. Медицинская иммунология. 2014;16(2):127-138. https://doi.org/10.15789/1563-0625-2014-2-127-138

For citation:


Smirnova S.V., Smolnikova M.V. IMMUNE PATHOGENESIS OF PSORIASIS AND PSORIATIC ARTHRITIS. Medical Immunology (Russia). 2014;16(2):127-138. (In Russ.) https://doi.org/10.15789/1563-0625-2014-2-127-138

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