МАЛЫЕ СУБПОПУЛЯЦИИ Т-ХЕЛПЕРОВ (Th НАИВНЫЕ ТИМИЧЕСКИЕ, Th НАИВНЫЕ ЦЕНТРАЛЬНЫЕ, Th9, Th22 И CD4+CD8+ ДВАЖДЫ ПОЛОЖИТЕЛЬНЫЕ Т-КЛЕТКИ)
https://doi.org/10.15789/1563-0625-2013-6-503-512
Аннотация
Резюме. Одну из ключевых ролей в процессах, происходящих в организме при попадании чужеродного антигена, играют Т-клетки, а именно Т-хелперы (Th). Появление новых высокочувствительных инструментов позволило исследовать более тонкую структурную организацию Т-клеток, выявить среди них целый ряд функционально значимых малых субпопуляций. Данные Т-клетки были охарактеризованы как фенотипически, так и функционально. Представленный обзор посвящен Th наивным тимическим, Th наивным центральным, Th9, Th22 и CD4+CD8+ дважды положительным Т-клеткам, отражена их роль и функциональная значимость при различных патологических состояниях. В настоящее время имеются четкие данные о наличии определенных наборов мембранных молекул, транскрипционных факторов и продукции специфических медиаторов иммунной системы, отличающих эти субпопуляции.
Использование этих данных в лабораторных исследованиях, несомненно, скажется на качестве диагностики нарушений функционирования иммунной системы и адекватности назначаемой иммунотерапии.
Об авторе
С. В. Хайдуков
ФГБУ «Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава РФ, Москва;
Технопарк, ФГБУН «Институт биоорганической химии имени академиков М.М. Шемякина и Ю.А. Овчинникова» РАН, Москва
Россия
Россия
д.б.н., заведующий лабораторией клеточной иммунологии, старший научный сотрудник
117997, ГСП-7, ул. Миклухо-Маклая, 16/10. Тел.: 8 (985) 923-41-62
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Рецензия
Для цитирования:
Хайдуков С.В. МАЛЫЕ СУБПОПУЛЯЦИИ Т-ХЕЛПЕРОВ (Th НАИВНЫЕ ТИМИЧЕСКИЕ, Th НАИВНЫЕ ЦЕНТРАЛЬНЫЕ, Th9, Th22 И CD4+CD8+ ДВАЖДЫ ПОЛОЖИТЕЛЬНЫЕ Т-КЛЕТКИ). Медицинская иммунология. 2013;15(6):503-512. https://doi.org/10.15789/1563-0625-2013-6-503-512
For citation:
Khaidukov S.V. MINOR SUBSETS OF T-HELPER CELLS (Th THYMIC NAIVE, Th CENTRAL NAIVE, Th9, Th22 AND CD4+CD8+ DOUBLE POSITIVE T-CELLS). Medical Immunology (Russia). 2013;15(6):503-512. (In Russ.) https://doi.org/10.15789/1563-0625-2013-6-503-512
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