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PATIENT-CENTRED SCREENING FOR PRIMARY IMMUNODEFICIENCY, A MULTI-STAGE DIAGNOSTIC PROTOCOL DESIGNED FOR NONIMMUNOLOGISTS: 2011 UPDATE

https://doi.org/10.15789/1563-0625-2013-5-477-492

Abstract

Abstract. Members of the European Society for Immunodeficiencies (ESID) and other colleagues have updated themulti-stage expert-opinion-based diagnostic protocol for non-immunologists incorporating newly defined primary immunodeficiency diseases (PIDs). The protocol presented here aims to increase the awareness of PIDs among doctors working in different fields. Prompt identification of PID is important for prognosis, but this may not be an easy task. The protocol therefore starts from the clinical presentation of the patient. Because PIDs may present at all ages, this protocol is aimed at both adult and paediatric physicians. The multi-stage design allows cost-effective screening for PID of the large number of potential cases in the early phases, with more expensive tests reserved for definitive classification in collaboration with a specialist in the field of immunodeficiency at a later stage.

About the Authors

E. de Vries
Jeroen Bosch Hospital ’s-Hertogenbosch
Netherlands
Department of Paediatrics


A. A. Cardona
Instituto Nacional de Pediatr a, Universidad Aut noma de M xico, Ciudad de Mexico
Mexico
Primary Immunodeficiency Investigation Unit


A. H. Abdul Latiff
Division of Clinical Immunology and Paediatrics School of Medicine and Health Sciences, Monash University, Sunway Campus
Malaysia


R. Badolato
Clinica Pediatrica dell’Universit di Brescia c/o Spedali Civili, Brescia, Italy
Italy


N. Brodszki
Lund University Hospital, Lund
Sweden
Department of Paediatric Immunology


A. J. Cant
Great North Children’s Hospital, Newcastle upon Tyne
United Kingdom


J. Carbone
Department of Immunology, Gregorio Mara on Hospital, Madrid
Spain


J. T. Casper
Medical College of Wisconsin, MACC Fund Research Center, Milwaukee
United States
Department of Paediatrics, Immunology/BMT


A. Ciznar
Comenius University Medical School, Children’ University Hospital, Bratislava
Slovakia
1st Paediatric Department


A. V. Cochino
University of Medicine and Pharmacy ‘Carol Davila’, Bucharest
Romania
Department of Paediatrics


B. Derfalvi
Semmelweis University Budapest, Budapest
Hungary
2nd Department of Paediatrics, Immunology–Rheumatology–Nephrology Unit


G. J. Driessen
Erasmus MC, University Medical Center Rotterdam, Rotterdam
Netherlands
Department of Paediatric Infectious Disease and Immunology


R. Elfeky
Ain Shams University, Cairo
Egypt
Department of Pediatrics


D. El-Ghoneimy
Ain Shams University, Cairo
Russian Federation
Department of Paediatric Allergy & Immunology, Faculty of Medicine


T. Espanol
University Hospital Vall d’Hebron, Barcelona
Spain
Immunology Unit


A. Etzioni
Meyer’s Children Hospital, Faculty of Medicine, Technion, Haifa
Israel


E. Gambineri
University of Florence, ‘Anna Meyer’ Children’s Hospital, Florence
Italy
Department of Sciences for Woman and Child’s Health


K. Gilmour
Great Ormond Street for Children NHS Trust, London
United Kingdom
Camelia Botnar Laboratories


L. I. Gonzalez-Granado
Hospital 12 octubre, Madrid
Spain
Immunodeficiencies Unit, Department of Paediatrics


M. N. Guseva
St. Petersburg Pediatric Medical Academy, St. Petersburg
Russian Federation
Consulting Center


M. H. Haverkamp
Leiden University Medical Center, Leiden
Netherlands
Department of Infectious Diseases


M. Helminen
University Hospital of Tampere, Tampere
Finland
Department of Paediatric Infectious Diseases


M. Honig
University Hospital Ulm, Ulm
Germany
Department of Paediatrics


M. G. Kanariou
Specific Center & Referral Center for Primary Immunodeficiencies – Paediatric Immunology, ‘Aghia Sophia’ Children’s Hospital, Athens
Greece


M. Kirschfink
Institute of Immunology, University of Heidelberg, Heidelberg
Germany


C. Klein
University Children’s Hospital, Dr von Haunersches Kinderspital, Munich
Germany


T. W. Kuijpers
Emma Children’s Hospital, Academic Medical Center, Amsterdam
Netherlands
Division of Paediatric Hematology, Immunology and Infectious diseases


N. Kutukculer
Ege University, Izmir
Turkey
Department of Pediatrics, Division of Pediatric Immunology


B. Martire
Policlinico Universit di Bari, Bari
Italy
Dipartimento di Biomedicina dell’Eta Evolutiva


I. Meyts
University Hospitals Leuven, Leuven
Belgium
Department of Paediatrics


T. Niehues
Helios Klinikum Krefeld; Krefeld Immunodeficiency Centre KIDZ, Krefeld
Germany


C. Pignata
‘Federico II’ University, Naples
Italy
Department of Paediatrics


S. M. Reda
Ain Shams University, Cairo
Egypt
Department of Paediatric Allergy and Immunology, Faculty of Medicine


E. D. Renner
University Children’s Hospital, Ludwig Maximilians Universit t, Munchen
Germany


N. Rezaei
Children’s Medical Center, Tehran University of Medical Sciences, Tehran
Islamic Republic of Iran
Molecular Immunology Research Centre and Research Group for Immunodeficiencies


M. Rizzi
University Medical Center Freiburg, Freiburg
Germany
Center for Chronic Immunodeficiency


M. A. Sampalo Lainz
Puerta del Mar Universitary Hospital, Cadiz
Spain
Department of Immunology


R. B. Sargur
Northern General Hospital, Sheffield
United Kingdom
Department of Immunology


A. Sediva
Institute of Immunology, University Hospital Motol, Prague
Czech Republic


M. G. Seidel
St Anna Children’s Hospital, Vienna
Austria
Paediatric Immunology Outpatient Clinic


S. L. Seneviratne
St Mary’s Hospital and Imperial College, London
United Kingdom
Department of Clinical Immunology


P. Soler-Palacin
Vall d’Hebron University Hospital, Barcelona
Spain
Pediatric Infectious Diseases and Immunodeficiencies Unit


A. Tommasini
Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste
Italy
Laboratory of Immunopathology


K. Warnatz
University Hospital of Freiburg, Freiburg
Germany
Centre of Chronic Immunodeficiency


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Review

For citations:

de Vries E., Cardona A.A., Abdul Latiff A.H., Badolato R., Brodszki N., Cant A.J., Carbone J., Casper J.T., Ciznar A., Cochino A.V., Derfalvi B., Driessen G.J., Elfeky R., El-Ghoneimy D., Espanol T., Etzioni A., Gambineri E., Gilmour K., Gonzalez-Granado L.I., Guseva M.N., Haverkamp M.H., Helminen M., Honig M., Kanariou M.G., Kirschfink M., Klein C., Kuijpers T.W., Kutukculer N., Martire B., Meyts I., Niehues T., Pignata C., Reda S.M., Renner E.D., Rezaei N., Rizzi M., Sampalo Lainz M.A., Sargur R.B., Sediva A., Seidel M.G., Seneviratne S.L., Soler-Palacin P., Tommasini A., Warnatz K. PATIENT-CENTRED SCREENING FOR PRIMARY IMMUNODEFICIENCY, A MULTI-STAGE DIAGNOSTIC PROTOCOL DESIGNED FOR NONIMMUNOLOGISTS: 2011 UPDATE. Medical Immunology (Russia). 2013;15(5):477-492. (In Russ.) https://doi.org/10.15789/1563-0625-2013-5-477-492

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