IMMUNOLOGICAL FEATURES OF OBESITY AND THEIR INTERRELATION WITH VIOLATIONS OF A CARBOHYDRATE AND FATTY EXCHANGES
https://doi.org/10.15789/1563-0625-2013-5-465-470
Abstract
Abstract. The article deals with biological issues of obesity, a global epidemic of XXI century. Adipose tissue is considered not only an energy-storage tissue, but as an endocrine organ as well which secretes a variety of bioactive substances (adipokines) including tumor necrosis factor (TNF)-α, interleukin-6 (IL-6). Cardiovascular diseases represent the main cause of morbidity and mortality in persons with excessive weight and obese patients. Atherosclerotic lesions represent a pathological substrate of these illnesses. The aim of our study was to analyze corelations between some specific adipocytokines (such as leptine) and some nonspecific cytokines (such as IL-6, TNFα) with indicators of lipid and carbohydrate metabolism. The study group included 123 persons (100 subjects with overweight and obesity, 23 persons with normal weight).
The article present results of studying immune parameters of patients with obesity, including cytokine levels, major classes of immunoglobulins, lymphocyte subpopulations in blood serum, and their interrelations with disturbances of carbohydrate and fat metabolism.
About the Authors
A. F. Salikhova
Bashkir State Medical University, Russian Ministry of Health Care, Ufa
Russian Federation
Russian Federation
PhD candidate, Department of Therapy and General Practice, Institute of Postgraduate Education
453124, Republic of Bashkortostan, Sterlitamak Sacco and Vancetti str., 67, apt 23. Phone: 7 (961) 355-27-45
L. M. Farkhutdinova
Bashkir State Medical University, Russian Ministry of Health Care, Ufa
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, Department of Therapy and General Practice, Institute of Postgraduate Education
References
1. Гончаров Н.П. Роль адипокинов в развитии ожирения // Вестник РАМН. – 2009. – № 9. – С. 43-48. Goncharov N.P. Rol` adipokinov v razvitii ozhireniya х Role of adipokines in development of obesity]. Vestnik RAMN – Bulletin of the Russian Academy of Medical Sciences, 2009, no. 9, pp. 43-48.
2. Дедов И., Мельниченко Г., Романцова Т., Бобров А., Вознесенская Т., Роик О., Гурова О., Полубояринова И., Волкова Г., Бухарова Г. Современные методы лечения ожирения // Врач. – 2008. – № 8. – С. 5-8. Dedov I., Mel`nichenko G., Romantsova T., Bobrov A., Voznesenskaya T., Roik O., Gurova O., Poluboyarinova I., Volkova G., Bukharova G. Sovremennye metody lecheniya ozhireniya [Modern methods of treatment obesity]. Vrach – Doctor, 2008, no. 8, pp. 5-8.
3. Дедов И.И., Балаболкин М.И., Мамаева Г.Г., Клебанова Е.М., Креминская В.М. Инсулиновая резистентность и роль гормонов жировой ткани в развитии сахарного диабета: Пособие для врачей. – М., 2005. – 88 с. Dedov I.I., Balabolkin M.I., Mamaeva G.G., Klebanova E.M., Kreminskaya V.M. Insulinovaya rezistentnost` i rol` gormonov zhirovoy tkani v razvitii sakharnogo diabeta. Posobie dlya vrachey [Insulin resistance and role of hormones of fatty tissue in diabetes development. Grant for doctors]. Moscow, 2005. 88 p.
4. Остроухова Е., Красильникова Е. Ожирение // Врач. – 2009. – № 11. – С. 33-36. Ostroukhova E., Krasil`nikova E. Ozhirenie [Obesity]. Vrach – Doctor, 2009, no. 11, pp. 33-36.
5. Румянцев П.О., Саенко В.А., Румянцева У.В. Статистические методы анализа в клинической практике. Часть I. Одномерный статистический анализ // Проблемы эндокринологии. – 2009. – Т. 55, № 5. – С. 48-55. Rumyantsev P.O., Saenko V.A., Rumyantseva U.V. Statisticheskie metody analiza v klinicheskoy praktike. Chast` I. Odnomernyy statisticheskiy analiz [Statistical methods of the analysis in clinical practice. Part I. One-dimensional statistical analysis]. Problemy endokrinologii – Endocrinology Problems, 2009, vol. 55. no. 5, pp. 48-55.
6. Трошина И.А, Гагина Т.А., Петров И.М., Медведева И.В. Метаболический синдром, как проявление взаимосвязи нервной, эндокринной и иммунной систем // Вестник Новосибирского государственного университета, серия: биология и клиническая медицина. – 2006. – Т. 4, № 3. – С. 92-101. Troshina I.A, Gagina T.A., Petrov I.M., Medvedeva I.V. Metabolicheskiy sindrom, kak proyavlenie vzaimosvyazi nervnoy, endokrinnoy i immunnoy sistem [Metabolic syndrome, as manifestation of interrelation nervous, endocrine and immune system]. Vestnik Novosibirskogo gosudarstvennogo universiteta, seriya: biologiya i klinicheskaya meditsina – Bulletin of Novosibirsk State University. Series: Biology and Clinical Medicine, 2006, vol. 4, no. 3, pp. 92-101.
7. Цибулькина В.Н., Цибулькин Н.А. Бронхиальная астма и ожирение: совпадение или закономерность? // Практическая медицина. Акушерство. Гинекология. Эндокринология. – 2011. – Т. 54, № 6. – С. 36-41. Tsibul`kina V.N., Tsibul`kin N.A. Bronkhial`naya astma i ozhirenie: sovpadenie ili zakonomernost`? [Bronchial asthma and obesity: coincidence or regularity?]. Prakticheskaya meditsina. Akusherstvo. Ginekologiya. Endokrinologiya – Practical Medicine. Obstetrics. Gynecology. Endocrinology, 2011, vol. 54, no. 6, pp. 36-41.
8. Шварц В. Жировая ткань как эндокринный орган // Проблемы эндокринологии. – 2009. – Т. 55, № 1. – С. 38-44. Shvarts V. Zhirovaya tkan` kak endokrinnyy organ [Adipose tissue as endocrine organ]. Problemy endokrinologii – Endocrinology Problems, 2009, vol. 55, no. 1, pp. 38-44.
9. Шварц В. Регуляция метаболических процессов интерлейкином-6 // Цитокины и воспаление. – 2009. – Т. 8, № 3. – С. 3-10. Shvarts V. Regulyatsiya metabolicheskikh protsessov interleykinom-6 [Regulation of metabolic processes by interleykin-6]. Tsitokiny i vospalenie – Cytokines and Inflammation, 2009, vol. 8, no. 3, pp. 3-10.
10. Balistreri C.R., Caruso C., Candore G. The role of adipose tissue and adipokines in obesity-related inflammatory diseases. Mediators Inflamm., 2010, 2010:802078.
11. Greenberg A.S., Obin M.S. Obesity and the role of adipose tissue in inflammation and metabolism. Am. J. Clin. Nutr., 2006, vol. 83, pp. 461S-465S.
Review
For citations:
Salikhova A.F., Farkhutdinova L.M. IMMUNOLOGICAL FEATURES OF OBESITY AND THEIR INTERRELATION WITH VIOLATIONS OF A CARBOHYDRATE AND FATTY EXCHANGES. Medical Immunology (Russia). 2013;15(5):465-470. (In Russ.) https://doi.org/10.15789/1563-0625-2013-5-465-470
Views:
1502
Email this article 