INFLUENCE OF SOLUBLE PLACENTADERIVED FACTORS UPON EXPRESSION OF SURFACE RECEPTORS ON THP-1 CELLS
https://doi.org/10.15789/1563-0625-2013-5-449-456
Abstract
Abstract. During the passage through the utero-placental circulation, peripheral blood monocytes are exposed to action of various soluble placenta-derived factors. Subsequently these cells migrate to placental tissue and play a key role in regulation of placental growth and development. We investigated the influence of placental secretory factors upon expression of THP-1 cells surface receptors during normal pregnancy, and pregnancy complicated with preeclampsia. Soluble placenta-derived factors produced by the third-trimester placenta caused reduced intensity of CD11а, CD18, CD54, CD14, TRAIL and VEGFR1 expression on THP-1 cells, as compared with the first-trimester placental extracts. Soluble placenta-derived factors from preeclamptic placenta caused an increased intensity of CD18 and CD54 expression by THP-1 cells and decreased intensity of VEGFR1 expression in comparison to normal pregnancy. The work was supported by grants of the President of the Russian Federation № НШ-131.2012.7, СП-3492.2013.4 МК-1580.2013.7 and by grant РФФИ № 13-04-00304 А.
Supporting agencies: grants of the President of the Russian Federation and grant РФФИ
About the Authors
T. Yu. Lvova
D. Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, St. Petersburg
Russian Federation
Research assistant, Department of Immunology
Russian Federation
Research assistant, Department of Immunology
Ya. S. Onochina
D. Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, St. Petersburg
Russian Federation
Russian Federation
Research assistant, Department of Immunology
D. A. Korenkov
D. Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, St. Petersburg
Russian Federation
Russian Federation
Senior Research Associate, Department of Immunology
O. I. Stepanova
D. Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, St. Petersburg
Russian Federation
Russian Federation
Research Associate, Department of Immunology
K. N. Furaeva
D. Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, St. Petersburg
Russian Federation
Student, Department of Immunology
Russian Federation
Student, Department of Immunology
E. A. Potolicina
D. Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, St. Petersburg
Russian Federation
Student, Department of Immunology
Russian Federation
Student, Department of Immunology
S. A. Selkov
D. Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, St. Petersburg
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, Chief, Department of Immunology
D. I. Sokolov
D. Ott Research Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, St. Petersburg
Russian Federation
Russian Federation
PhD, MD, Senior Research Associate, Department of Immunology
199034, Mendeleev Line, 3. Phone: 7 (812) 328-98-50
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Review
For citations:
Lvova T.Yu., Onochina Ya.S., Korenkov D.A., Stepanova O.I., Furaeva K.N., Potolicina E.A., Selkov S.A., Sokolov D.I. INFLUENCE OF SOLUBLE PLACENTADERIVED FACTORS UPON EXPRESSION OF SURFACE RECEPTORS ON THP-1 CELLS. Medical Immunology (Russia). 2013;15(5):449-456. (In Russ.) https://doi.org/10.15789/1563-0625-2013-5-449-456
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