СВОБОДНАЯ ВНЕКЛЕТОЧНАЯ ДНК В НОРМЕ И ПРИ ПАТОЛОГИИ
Аннотация
Резюме. В работе представлены литературные данные о существовании в организме свободной ДНК (свДНК), не связанной с клетками, которая определяется практически во всех жидкостях организма. Данные свидетельствуют о том, что свДНК определяется в нормальном, здоровом организме. При этом повышение уровня свДНК в плазме и сыворотке крови определяется при многих заболеваниях, включая аутоиммунные заболевания, злокачественные новообразования, инфаркт миокарда и др. Во многих случаях уровень свДНК становится предиктором появления того или иного заболевания, а также утяжеления течения болезни. До сих пор не ясна физиологическая роль свДНК, а также ее значение в развитии того или иного заболевания. Показано, что свДНК может стимулировать и подавлять функции иммунокомпетентных клеток, может выполнять роль индуктора аутоиммунных состояний. Кроме того, предполагается, что свДНК может служить переносчиком генетической информации в организме между опухолевыми и нормальными клетками, так же как между последними из различных органов и тканей.
Об авторе
В. А. Козлов
ФГБУ «Научно-исследовательский институт клинической иммунологии» СО РАМН, г. Новосибирск
Россия
Россия
д.м.н., профессор, академик РАМН, директор
630090, ул. Ядринцевская, 14. Тел.: 8 (383) 222-66-27. Факс: 8 (383) 222-70-28
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Для цитирования:
Козлов В.А. СВОБОДНАЯ ВНЕКЛЕТОЧНАЯ ДНК В НОРМЕ И ПРИ ПАТОЛОГИИ. Медицинская иммунология. 2013;15(5):399-412. https://doi.org/10.15789/1563-0625-2013-5-399-412
For citation:
Kozlov V.А. FREE EXTRACELLULAR DNA IN NORMAL STATE AND UNDER PATHOLOGICAL CONDITIONS. Medical Immunology (Russia). 2013;15(5):399-412. (In Russ.) https://doi.org/10.15789/1563-0625-2013-5-399-412
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