IMMUNE COMPLEXES AS INDICES OF CHRONIC INFLAMMATION ACCOMPANYING POSTTRAUMATIC STRESS DISORDER
https://doi.org/10.15789/1563-0625-2012-6-545-548
Abstract
C1q- and C3d-IC, were determined in patients with posttraumatic stress disorder (PTSD), as compared to healthy subjects, using an enzyme-linked immunosorbent assay. According to the data obtained, the levels of both C1q- и C3d-IC were significantly increased in PTSD-patients versus healthy subjects, thus reflecting hyperactivation of classical complement pathway detected in this pathology. Moreover, a significant positive correlation was found between C1q- and C3d-IC levels in PTSD group. It was concluded that PTSD is characterized by altered mechanisms of IC recognition and elimination that may underly chronic activation of immune system and systemic inflammatory response associated with this disorder.
About the Authors
L. P. Hovhannisyan
Институт молекулярной биологии НАН РА, г. Ереван
Armenia
Armenia
A. S. Boyajyan
Институт молекулярной биологии НАН РА, г. Ереван
Armenia
Armenia
G. M. Mkrtchyan
Институт молекулярной биологии НАН РА, г. Ереван
Armenia
Armenia
S. H. Sukiasyan
«АртМед» Медицинский реабилитационный центр, г. Ереван
Armenia
Armenia
V. A. Ayvazyan
Институт молекулярной биологии НАН РА, г. Ереван
Armenia
Armenia
M. S. Petrosyan
Научный центр Арцаха
Armenia
Armenia
K. K. Harutyunyan
Научный центр Арцаха
Armenia
Armenia
R. I. Musaelian
Научный центр Арцаха
Armenia
Armenia
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Review
For citations:
Hovhannisyan L.P., Boyajyan A.S., Mkrtchyan G.M., Sukiasyan S.H., Ayvazyan V.A., Petrosyan M.S., Harutyunyan K.K., Musaelian R.I. IMMUNE COMPLEXES AS INDICES OF CHRONIC INFLAMMATION ACCOMPANYING POSTTRAUMATIC STRESS DISORDER. Medical Immunology (Russia). 2012;14(6):545-548. (In Russ.) https://doi.org/10.15789/1563-0625-2012-6-545-548
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