COMPARATIVE ANALYSIS OF DEVELOPMENT OF CHLAMYDOPHILA AND SALMONELLA INFECTIONS IN THE INBRED MICE DIFFERENT IN THEIR SENSITIVITES TO M.TUBERCULOSIS
https://doi.org/10.15789/1563-0625-2005-5-6-583-586
Abstract
Abstract. The course of infections caused by intracellular parasitic bacteria Salmonella typhimurium and Chlamidophila pneumoniae was compared for inbred strains of mice with genetically determined susceptibity (I/St) or resistance (A/Sn) to Mycobacterium tuberculosis.
Similar differences in dynamics of some common parameters (life span and pathogen numbers in affected or gans) between A/Sn and I/St mice have been revealed for tuberculosis, salmonellosis and chlamidiasis. There has been demonstrated that A/Sn animals show increased resistance to Salmonella and Chlamidia infections, as compared to I/St mice, in spite of various mechanisms of intracellular parasitism for S.typhimurium and C.Pneumoniae, and different locations of lesions induced by these bacteria in the host organism.
Similar features of quite different infections at the level of macroorganism allows us to suggest that further investigation in A/Sn and I/St murine model will make it able to discover the basic features of physiolog$ical control for a lot of infections, and to reveal a genetic network that could be responsible for their favorable or adverse outcomes. (Med. Immunol., 2005, vol.7, № 5–6, pp. 583–586)
About the Authors
D. V. Balunets
ГУ НИИ эпидемиологии и микробиологии им. Гамалеи РАМН
Russian Federation
Russian Federation
L. N. Nesterenko
ГУ НИИ эпидемиологии и микробиологии им. Гамалеи РАМН
Russian Federation
Russian Federation
Yu. S. Romanova
ГУ НИИ эпидемиологии и микробиологии им. Гамалеи РАМН
Russian Federation
Russian Federation
Yu. S. Alyapkina
ГУ НИИ эпидемиологии и микробиологии им. Гамалеи РАМН
Russian Federation
Russian Federation
N. I. Kolkova
ГУ НИИ эпидемиологии и микробиологии им. Гамалеи РАМН
Russian Federation
Russian Federation
A. S. Apt
ГУ Центральный НИИ туберкулеза РАМН, Москва
Russian Federation
Russian Federation
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Review
For citations:
Balunets D.V., Nesterenko L.N., Romanova Yu.S., Alyapkina Yu.S., Kolkova N.I., Apt A.S. COMPARATIVE ANALYSIS OF DEVELOPMENT OF CHLAMYDOPHILA AND SALMONELLA INFECTIONS IN THE INBRED MICE DIFFERENT IN THEIR SENSITIVITES TO M.TUBERCULOSIS. Medical Immunology (Russia). 2005;7(5-6):583-586. (In Russ.) https://doi.org/10.15789/1563-0625-2005-5-6-583-586
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