CYTOKINE-PRODUCING POTENTIAL OF BLOOD CELLS AND SERUM CYTOKINES IN PATIENTS WITH CHRONIC ATROPHIC GASTRITIS
https://doi.org/10.15789/1563-0625-2013-3-247-254
Abstract
Abstract. Cytokine-producing potential of peripheral blood cells was determined as a stimulation index with polyclonal activators (i.e., a cytokine production ratio of stimulated versus resting cells), as well as concentrations of cytokines were investigated in blood serum of patients with chronic atrophic gastritis. It was revealed that the stimulation indices concerning production of TNFα, IL-1β, IL-6, IL-8 and IL-10 by whole blood cells, along with serum concentrations of IL-8 and IL-18BP were increased in patients with epithelial dysplasia of stomach mucosa, as compared to patients without dysplasia. It was sahown, that the patients with higher polyclonal stimulation indices for IL-6 and IL-8 (resp., > 164 and > 38 arbitrary units) should be referred to a high-risk group for development of mucous epithelial dysplasia of stomach.
About the Authors
A. V. Sosnina
Research Institute of Molecular Biology and Biophysics, Russian Academy of Medical Sciences, Siberian Branch, Novosibirsk
Russian Federation
Russian Federation
PhD (Medicine), Leading Research Associate, Laboratory of Physico-Chemical Indication of Immune Processes,
E. S. Mikhailova
Research Institute of Molecular Biology and Biophysics, Russian Academy of Medical Sciences, Siberian Branch, Novosibirsk
Russian Federation
Russian Federation
Senior Research Associate, Laboratory of Physico-Chemical Indication of Immune Processes
A. I. Autenshlyus
Research Institute of Molecular Biology and Biophysics, Russian Academy of Medical Sciences, Siberian Branch, Novosibirsk
Russian Federation
Russian Federation
PhD, MD (Biology), Professor, Chief, Laboratory of Physico-Chemical Indication of Immune Processes
N. A. Varaksin
Vector Best Ltd, Novosibirsk Region
Russian Federation
Chief, The Cytokine Laboratory
Russian Federation
Chief, The Cytokine Laboratory
N. A. Dotoleva
Novosibirsk State Medical University, Novosibirsk
Russian Federation
Physician (Endoscopist)
Russian Federation
Physician (Endoscopist)
I. P. Mikhno
Novosibirsk State Medical University, Novosibirsk
Russian Federation
Pathologist
Russian Federation
Pathologist
T. A. Ageeva
Novosibirsk State Medical University, Novosibirsk
Russian Federation
Russian Federation
MD, Professor, Department of Pathological Anatomy, Therapeutic Faculty
L. A. Shpagina
Novosibirsk State Medical University, Novosibirsk
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, Chief, Department of Hospital Therapy and Medical Rehabilitation, Pediatric Faculty
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Review
For citations:
Sosnina A.V., Mikhailova E.S., Autenshlyus A.I., Varaksin N.A., Dotoleva N.A., Mikhno I.P., Ageeva T.A., Shpagina L.A. CYTOKINE-PRODUCING POTENTIAL OF BLOOD CELLS AND SERUM CYTOKINES IN PATIENTS WITH CHRONIC ATROPHIC GASTRITIS. Medical Immunology (Russia). 2013;15(3):247-254. (In Russ.) https://doi.org/10.15789/1563-0625-2013-3-247-254
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