EFFECTS OF SECRETABLE PLACENTAL FACTORS UPON SECRETION OF CYTOKINES BY THP-1 MONOCYTE-LIKE CELLS
https://doi.org/10.15789/1563-0625-2013-3-227-234
Abstract
Abstract. Мonocytes in feto-placental circulation are exposed to factors secreted by placental tissue. These factors influence monocyte functions in pregnancy. In present study, an in vitro model (monocyte-like THP-1 cells) was used for assessing effects of soluble placental factors obtained from women with physiological pregnancies, or preeclampsia cases. The following effects of placental factors were revealed: increased secretion of VEGF by THP-1 cells along with decreased secretion of IL-6, IL-8 and MCP-1 under the influence of placental factors from the I. trimester of pregnancy in comparison with III. trimester. Secretion of IL-6 and MCP-1 by THP-1 cells was increased, and secretion of soluble TNFRII was decreased upon co-cultivation with soluble placental factors from the women with preeclampsia, as compared with placental products from physiological pregnancies.
The work is supported by grants ГК № 02.740.11.0711 from Ministry of Education and Science, and НШ-3594.2010.7 grant from the President of Russian Federation.
Supporting agencies: Ministry of Education and Science, grant from the President of Russian Federation
About the Authors
Ya. S. Onokhina
D. Ott Research Institute of Obstetrics and Gynecology, St. Petersburg
Russian Federation
Russian Federation
Investigator (Biologist), Laboratory of Immunology with an AIDS Diagnostic Group
T. Yu. Lvova
D. Ott Research Institute of Obstetrics and Gynecology, St. Petersburg
Russian Federation
Russian Federation
Investigator (Biologist), Laboratory of Immunology with an AIDS Diagnostic Group
D. Z. Tzitzkarava
D. Ott Research Institute of Obstetrics and Gynecology, St. Petersburg
Russian Federation
Russian Federation
Resident Physician, Laboratory of Immunology with an AIDS Diagnostic Group
S. A. Selkov
D. Ott Research Institute of Obstetrics and Gynecology, St. Petersburg
Russian Federation
Russian Federation
PhD, MD (Medicine), Professor, Chief, Laboratory of Immunology with an AIDS Diagnostic Group
D. I. Sokolov
D. Ott Research Institute of Obstetrics and Gynecology, St. Petersburg
Russian Federation
Russian Federation
PhD, MD (Biology), Leading Researcher, Laboratory of Immunology with an AIDS Diagnostic Group
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Review
For citations:
Onokhina Ya.S., Lvova T.Yu., Tzitzkarava D.Z., Selkov S.A., Sokolov D.I. EFFECTS OF SECRETABLE PLACENTAL FACTORS UPON SECRETION OF CYTOKINES BY THP-1 MONOCYTE-LIKE CELLS. Medical Immunology (Russia). 2013;15(3):227-234. (In Russ.) https://doi.org/10.15789/1563-0625-2013-3-227-234
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