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CONTENTS OF LYMPHOCYTE SUB-POPULATIONS IN THE CHILDREN WITH ACUTE LEUKEMIA AND LYMPHOMAS DEPENDENT ON INFECTIOUS COMPLICATION AND NEUTROPENIA

https://doi.org/10.15789/1563-0625-2005-5-6-551-556

Abstract

Abstract. The aim of the present work was to evaluate the contents of some lymphocyte sub-populations in peripheral blood of the children with tumors of hematopoietic and lymphoid tissues, depending on infectious complication of cytostatic therapy and neutropenia. In all children undergoing cytostatic therapy for acute lympho-blastic leukemia and non-B cell non-Hodgkinґs lymphomas, we found significant decrease in the numbers of CD95 lymphocytes, absolute amounts of natural killer cells (CD16, CD56-lymphocytes) and activated lymphocytes (СD11b, HLA-DR-cells), irrespective of neutrophile numbers in their blood and infectious complications. However, absolute number of CD25- lymphocytes was significantly decreased in the children with neutropenia. Relative contents of CD16, CD56, СD11b, HLA-DR, CD25-lymphocytes did not significantly differ from those in healthy children, or they were found to be significantly increased.

About the Authors

M. V. Peshikova
Государственная медицинская академия, г. Челябинск
Russian Federation


I. I. Dolgushin
Государственная медицинская академия, г. Челябинск
Russian Federation


O. L. Kolesnikov
Государственная медицинская академия, г. Челябинск
Russian Federation


N. N. Rusanova
Государственная медицинская академия, г. Челябинск
Russian Federation


References

1. Алейникова О.В. Современные технологии диагностики и лечения острых лейкозов у детей. Дис. … д–ра мед. наук. — М., 1999. — 196 с.

2. Винокуров М.Г., Прохоренко И.Р., Юринская М.М., Долгачева Н.Н., Печатников В.А. Действие липополисахаридов и УФ–облучения диапазона С на регуляцию апоптоза нейтрофилов человека // Иммунология. — 2001. — № 2. — C. 25–27.

3. Гланц С. Медико–биологическая статистика: (пер. с англ.). — М.: Практика, 1998. — 459 с.

4. Грачева Л.А., Осипов С.Г., Еремеев В.С., Румянцев А.Г. Обоснование цитокиновой терапии опухолевых заболеваний иммунной системы // Гематология и трансфузиология. — 1998. — Т. 43, № 4. — С. 42 – 46.

5. Злокачественные новообразования кроветворной и лимфоидной ткани у детей / Под ред. Л.А. Дурнова. — М.: Медицина, 2001. — 272 с.

6. Кетлинский С.А., Калинина Н.М. Иммунология для врача. — Спб.: Гиппократ, 1998. — 156 с.

7. Масчан А.А., Самочатова Е.В., Крыжановский О.И. Тактика сопроводительной терапии при лечении острого лимфобластного лейкоза по программе БФМ // Педиатрия. — 1992. — № 2. — С. 68–78.

8. Махонова Л.А., Киселев А.В., Гордина Г.А., Кадагидзе З.Г. Интерферон и тактивин в программе лечения неходжкинских лимфом у детей в период ремиссии // Вопр. онкологии. — 1995. — № 2. — С. 80–81.

9. Маянский А.Н., Маянский Н.А., Заславская М.И., Поздеев Н.М., Плескова С.Н. Апоптоз нейтрофилов // Иммунология. — 1999. — № 6. — С. 11–20.

10. Маянский Н.А. Состояние каспазы–3 при подавлении апоптоза нейтрофилов гранулоцитарно–макрофагальным колониестимулирующим фактором // Иммунология. — 2001. — № 2. — С. 22– 25.

11. Румянцев А.Г., Самочатова Е.В., Табет Хамдан. Лечение острого лимфобластного лейкоза у детей по программе BFM // Педиатрия. — 1991. — № 11. — С. 58–63.

12. Сибиряк С.В., Юсупова Р.Ш., Курчатова Н.И. Иммунофенотипирование лимфоцитов в клинической практике. — Уфа, 1997. — 24 с.

13. Bergmann L., Heil G., Kolbe K., Lengfelder E., Puzicha E., Martin H., Lohmeyer J., Mitrou P.S., Hoelzer D. Interleukin–2 bolus infusion as late consolidation therapy in 2nd remission of acute myeloblastic leukemia // Leuk. Lymphoma. — 1995. — Vol. 16, № 3 – 4. — P. 271–279.

14. Bone R.C., Balk R.A., Cerra F.B. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis // Chest. — 1992. — Vol. 101. — P. 1644–1655.

15. Bone R.S., Sprung C.I., Sibbald W.J. Definitions of sepsis and organ failure // Crit. Care Med. — 1992. — Vol. 20. — P. 724–726.

16. Brach M.A., de Vos S., Gruss H.J., Herrmann F. Prolongation of survival of human polymorphonuclear neutrophils by granulocyte–macrophage colony–stimulating factor is caused by inhibition of programmed cell death // Blood. — 1992. — Vol. 80, № 11. — P. 2920–2924.

17. Chakraborty A., Chakraborty N.G., Chattopadhyay U. Age related natural killer activity of peripheral blood lymphocytes from healthy subjects and cancer patients. A comparative in vitro study with interleukin–2 // Tumori. — 1994. — Vol. 80, № 3. — P. 233 237. Erratum in: Tumori. — 1995. — Vol. 81, № 3. — Following 224.

18. Frasch S.C., Nick J.A., Fadok V.A., Bratton D.L., Worthen G.S., Henson P.M. p38 mitogen–activated protein kinase–dependent and –independent intracellular signal transduction pathways leading to apoptosis inhuman neutrophils // J. Biol. Chem. — 1998. — Vol. 273, № 14. — P. 8389–8397.

19. Grandgirard D., Studer E., Monney L., Belser T., Fellay I., Borner C., Michel M.R. Alphaviruses induce apoptosis in Bcl–2–overexpressing cells: evidence for a caspase–mediated, proteolytic inactivation of Bcl–2 // EMBO J. — 1998. — Vol. 17, № 5. — P. 1268–1278.

20. Kothakota S., Azuma T., Reinhard C., Klippel A., Tang J., Chu K., McGarry T.J., Kirschner M.W., Koths K., Kwiatkowski D.J., Williams L.T. Caspase–3generated fragment of gelsolin: effector of morphological change in apoptosis // Science. — 1997 – Vol. 278, № 5336. — P. 294–298.

21. Lord B.I., Gurney H., Chang J., Thatcher N., Crowther D., Dexter T.M. Haemopoietic cell kinetics in humans treated with rGM–CSF // Int. J. Cancer. — 1992. — Vol. 50, № 1. — P. 26–31.

22. Lorenzen J., Lewis C.E., McCracken D., Horak E., Greenall M., McGee J.O. Human tumor–associated NK cells secrete increased amounts of interferon–gamma and interleukin–4 // Br. J. Cancer. — 1991. — Vol. 64, № 3. — P. 457–462.

23. Meunder F. Infections in patients with acute leukemia and lymphoma // Principles and practice of infectious diseases / ed. by Mandell G.L. — New York: Churchill Livingstone, 1989. — P. 2265–2275.

24. Payne C.M., Glasser L., Tischler M.E., Wyckoff D., Cromey D., Fiederlein R., Bohnert O. Programmed cell death of the normal human neutrophil: an in vitro model of senescence // Microsc. Res. Tech. — 1994. — Vol. 28, № 4. — P. 327–344.

25. Rangel–Frausto M.S., Wenzel R.P. The epidemiology and natural history of bacterial sepsis // Sepsis and multiorgan failure. — New York, 1997. — P. 27–34.

26. Rook A.H., Kubin M., Cassin M., Vonderheid E.C., Vowels B.R., Wolfe J.T., Wolf S.F., Singh A., Trinchieri G., Lessin S.R. IL–12 reverses cytokine and immune abnormalities in Sezary syndrome // J. Immunol. — 1995. — Vol. 154, № 3. — P. 1491–1498.

27. Sanghavi D.M., Thelen M., Thornberry N.A., Casciola–Rosen L., Rosen A. Caspase–mediated proteolysis during apoptosis: insights from apoptotic neutrophils // FEBS Lett. — 1998. — Vol. 422, № 2. — P.179–184.

28. Thornberry N.A., Lazebnik Y. Caspases: enemies within // Science. — 1998. — Vol. 281, № 5381. — P.1312–1316.

29. Vaughan III V.C., Litt I.F. Assessment of growth and development // Nelson textbook of pediatrics / ed. by Behrman R.E. — Philadelphia: WB Saunders, 1992. — P. 32–43.

30. Woo M., Hakem R., Soegans M.S., Duncan G.S., Shahinian A., Kagi D., Hakem A., McCurrach M., Khoo W., Kaufman S.A., Senaldi G., Howard T., Lowe S.W., Mak T.W. Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes // Genes. Dev. — 1998. — Vol. 12, № 6. — P. 806–819.

31. Zheng T.S., Schlosser S.F., Dao T., Hingorani R., Crispe I.N., Boyer J.L., Flavell R.A. Caspase–3 controls both cytoplasmic and nuclear events associated with Fas–mediated apoptosis in vivo // Proc. Natl. Acad. Sci. USA. — 1998. — Vol. 95, № 23. — P. 13618–13623.


Review

For citations:


Peshikova M.V., Dolgushin I.I., Kolesnikov O.L., Rusanova N.N. CONTENTS OF LYMPHOCYTE SUB-POPULATIONS IN THE CHILDREN WITH ACUTE LEUKEMIA AND LYMPHOMAS DEPENDENT ON INFECTIOUS COMPLICATION AND NEUTROPENIA. Medical Immunology (Russia). 2005;7(5-6):551-556. (In Russ.) https://doi.org/10.15789/1563-0625-2005-5-6-551-556

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