MAJOR LYMPHOCYTE SUBPOPULATIONS IN COMBINED INFECTIONS HERPES VIRUS (HSV) AND VARIOUS FORMS OF TUBERCULOSIS
https://doi.org/10.15789/1563-0625-2010-1-2-139-142
Abstract
The goal of present work was to study main cell subpopulations of immune system, frequency of human herpes virus (HSV) type 1 activation, and presence of HSV in patients with tuberculosis (TB). We have shown an increased level of herpesvirus type 1 and type 2 manifestation in patients with different types of tuberculosis (TB). A statistically significant decrease in the CD4/CD8 ratio and in percentage of CD3+, CD4+ cells patients with certain clinical forms of TB was shown, as compared to the group with active HSV infection. The data obtained showed absence of correlation between TB-related reactions, HSV infection, and levels of HSV-specific antibodies. Deficient function of cells with natural killer (NK) activity, and decreased numbers of CD56+ cells have been also of shown. NK cells may be among most relevant components of immune reactions to HSV infection. Main role in HSV activation in the TB patients depends on deficiency of NK-like cells.
About the Author
M. A. Karalyan
Республиканский противотуберкулезный клинический диспансер Минздрава Республики Армении, г. Ереван
Russian Federation
Russian Federation
References
1. Гордиенко С.М. Приемлемый для клинической практики метод оценки активности естественных и антителозависимых киллерных клеток//Лабораторное дело. -1983. -№ 9. -С. 45-48.
2. Каралян М.А., Степанян С.М., Улумян А.К., Карапетян Э.Т. Роль герпес-вируса человека I в развитии туберкулезного менингоэнцефалита//Проблемы туберкулеза и болезней легких. -2005. -№ 12. -С. 39-41.
3. Хоменко. А.Г. Туберкулез: Руководство для врачей. -М.: Медицина -1996. -496 с.
4. Bona C., Bonilla F. Textbook of immunology, second ed. -Amsterdam.: Harwood Acad. Publ. -1996. -Р. 406.
5. Dunlap, N. E., and D. E. Briles. Immunology of tuberculosis//Med. Clin. North Am. -1993. -N 77. -P. 1235-1251.
6. Grubor-Bauk B., Arthur J.L., Mayrhofer G. Importance of NKT cells in resistance to herpes simplex virus, fate of virus-infected neurons, and level of latency in mice//J. Virol. 2008. -Vol. 82, N 22. -P. 11073-11083.
7. Nandakumar S., Woolard S.N., Yuan D., Rouse B.T., Kumaraguru U. Natural killer cells as novel helpers in anti-herpes simplex virus immune response//J. Virol. -2008. -Vol. 82, N 21. -P. 10820-10831.
8. Schierloh P., Aleman M., Yokobori N., Alves L., Roldan N., Abbate E., del C Sasiain M., de la Barrera S. NK cell activity in tuberculosis is associated with impaired CD11a and ICAM-1 expression: a regulatory role of monocytes in NK activation//Immunology. -2005. -Vol. 116, N 4. -P. 541-552.
9. Schiff D., Rosenblum M.K. Herpes simplex encephalitis (HSE) and the immunocompromised: A clinical and autopsy study of HSE in the settings of cancer and human immunodeficiency virus-type 1 infection//Hum. Pathol. -1998. -N 29. -P. 215.
10. Vankayalapati R., Klucar P., Wizel B., Weis S.E., Samten B., Safi H., Shams H., Barnes P.F. NK cells regulate CD8+ T cell effector function in response to an intracellular pathogen//J. Immunol. -2004. -Vol. 172, N 1. -P. 130-137.
Review
For citations:
Karalyan M.A. MAJOR LYMPHOCYTE SUBPOPULATIONS IN COMBINED INFECTIONS HERPES VIRUS (HSV) AND VARIOUS FORMS OF TUBERCULOSIS. Medical Immunology (Russia). 2010;12(1-2):139-142. (In Russ.) https://doi.org/10.15789/1563-0625-2010-1-2-139-142
Views:
1240
Email this article 