AGE-DEPENDENT FEATURES OF EVOLVING HUMORAL IMMUNITY IN CHILDREN
https://doi.org/10.15789/1563-0625-2012-4-5-289-294
Abstract
Abstract. Age dynamics of humoral immunity was studied in healthy children, i.e., 11 newborns, 33 infants of 4 to 8 months, 32 children of 1 to 2 years old,, 17 children of 4 to 5 years old, 25 children of 6 to 8 years old, 15 children of 9 to 11 years old, and 28 adolescents of 14 to 16 years old. Evaluation of membrane receptors on B cells was performed by means of three-colour fluorescent label and allowed of characterizing B1 subpopulations (CD19+CD5+CD27-), naпve B2 cells (CD19+CD5-CD27-), and B2 memory cells (CD19+CD5-CD27+). B1 cells have been shown to dominate in blood of newborns and younger children (up to 5 years old). By the contrary, B2 memory cells were nearly undetectable in newborns, and exceeded 20% in adolescents (by 15 years old). Meanwhile, it has been revealed that the amounts of IgG1 and IgG3 subclasses did progressively increase with age, whereas IgG2 remained decreased to 50% of adult values for a long time, and reached them by 11 years and later. We suggest that the age dynamics of IgG subclasses is connected with age-dependent changes in B cell subpopulations.
About the Authors
A. P. Toptygina
ФБУН Московский научно-исследовательский институт эпидемиологии и микробиологии
им. Г.Н. Габричевского, Москва
Russian Federation
Russian Federation
E. L. Semikina
Научный центр здоровья детей РАМН, Москва
Russian Federation
Russian Federation
E. A. Kopyltsova
Научный центр здоровья детей РАМН, Москва
Russian Federation
Russian Federation
V. A. Alyoshkin
ФБУН Московский научно-исследовательский институт эпидемиологии и микробиологии
им. Г.Н. Габричевского, Москва
Russian Federation
Russian Federation
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Review
For citations:
Toptygina A.P., Semikina E.L., Kopyltsova E.A., Alyoshkin V.A. AGE-DEPENDENT FEATURES OF EVOLVING HUMORAL IMMUNITY IN CHILDREN. Medical Immunology (Russia). 2012;14(4-5):289-294. (In Russ.) https://doi.org/10.15789/1563-0625-2012-4-5-289-294
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