THE GROUNDS OF CLARITROMYCIN USE IN THE TREATMENT OF PSORIASIS
https://doi.org/10.15789/1563-0625-2005-4-405-410
Abstract
Abstract. Claritromycin influence on the keratinocytes proliferation and differentiation and lymphocytes proliferation and clasters of differentiation expression in vitro was investigated. It was established that claritromycin in dose 2 mkg/ml inhibited psoriatic keratinocytes proliferation and increased its differentiation degree in culture. Claritromycin influence was mediated by CD4+ lymphocytes. Furthermore, claritromycin in vitro decreased the number of СD25+ lymphocytes and spontaneous and PHA-induced lymphocytes proliferation for psoriatic patients. These data allow to include claritromycin in the treatment regimen of psoriasis.
About the Author
V. L. Rybkina
Научно–исследовательский кожно–венерологический институт МЗ
Kazakhstan
Kazakhstan
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Review
For citations:
Rybkina V.L. THE GROUNDS OF CLARITROMYCIN USE IN THE TREATMENT OF PSORIASIS. Medical Immunology (Russia). 2005;7(4):405-410. (In Russ.) https://doi.org/10.15789/1563-0625-2005-4-405-410
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