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Медицинская иммунология

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ИНТЕРЛЕЙКИН–18 И ЕГО РОЛЬ В ИММУННОМ ОТВЕТЕ

https://doi.org/10.15789/1563-0625-2005-4-355-364

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Аннотация

Резюме. Интерлейкин–18 один из основных иммунорегуляторных цитокинов, индуцирующий продукцию IFNγ, что обуславливает его важное значение как фактора противоинфенкционной и противоопухолевой защиты организма. В представленном обзоре рассматриваются молекулярно–генетические и биохимические характеристики IL–18. Приведены данные о клетках продуцентах, строении рецептора и IL–18 связывающего белка, пути передачи сигнала в клетке. Кроме того, рассматриваются основные иммунорегуляторные эффекты IL–18.

Об авторах

Е. В. Якушенко
ГУ НИИ Клинической Иммунологии СО РАМН, Новосибирск
Россия
г. Новосибирск, ул. Ядринцевская, д. 14


Ю. А. Лопатникова
ГУ НИИ Клинической Иммунологии СО РАМН, Новосибирск
Россия


С. В. Сенников
ГУ НИИ Клинической Иммунологии СО РАМН, Новосибирск
Россия


Список литературы

1. Турчинович А.А., Дейнеко Е.В., Филипенко М.Л., Храпов Е.А., Загорская А.А., Филипенко Е.А., Сенников С.В., Козлов В.А., Шумный В.К. Получение трансгенных растений табака – продуцентов интерлейкина 18 человека // Доклады АН.– 2004.– Т. 395(5).– С.704–707.

2. Ahn H.J., Maruo S., Tomura M., Mu J., Hamaoka T., Nakanishi K., Clark S., Kurimoto M., Okamura H., Fujiwara H. A mechanism underlying synergy between IL–12 and IFN–gamma–inducing factor in enhanced production of IFN–gamma // J. Immunol. – 1997.– Vol. 159.– P.2125–31.

3. Akita K., Ohtsuki T., Nukada Y., Tanimoto T., Namba M., Okura T., Takakura–Yamamoto R., Torigoe K., Gu Y., Su M.S., Fujii M., Satoh–Itoh M., Yamamoto K., Kohno K., Ikeda M., Kurimoto M. Involvement of caspase–1 and caspase–3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells // J. Biol. Chem.– 1997.– Vol. 272. — P. 26595–603.

4. Bacon C.M., Petricoin E.F. 3rd, Ortaldo J.R., Rees R.C., Larner A.C., Johnston J.A., O’Shea J.J. Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes // Proc. Natl. Acad. Sci .USA. – 1995. – Vol. 92. – P.7307–11. 5. Cai G., Kastelein R.A., Hunter C.A. IL–10 enhances NK cell proliferation, cytotoxicity and production of IFN–gamma when combined with IL–18 // Eur. J. Immunol.–1999 .–Vol. 29.– P.2658–65.

5. Conti B., Jahng J.W., Tinti C., Son J.H., Joh T.H. Induction of interferon–gamma inducing factor in the adrenal cortex // J. Biol. Chem.– 1997.– Vol.272. — P.2035–7.

6. Conti B., Park L.C., Calingasan N.Y., Kim Y., Kim H., Bae Y., Gibson G.E., Joh T.H. Cultures of astrocytes and microglia express interleukin 18 // Brain Res. Mol. Brain Res.– 1999.–Vol.67.– P.46–52.

7. Dao T., Ohashi K., Kayano T., Kurimoto M., Okamura H. Interferon–gamma–inducing factor, a novel cytokine, enhances Fas ligand–mediated cytotoxicity of murine T helper 1 cells // Cell Immunol.– 1996. — Vol.173.– P230–5.

8. Demeure C.E., Tanaka H., Mateo V., Rubio M., Delespesse G., Sarfati M. CD47 engagement inhibits cytokine production and maturation of human dendritic cells// J. Immunol.– 2000.– Vol.164.– P.2193–9.

9. Dinarello C.A. IL–18: A TH1–inducing, proinflammatory cytokine and new member of the IL–1 family // J. Allergy Clin. Immunol.– 1999.– Vol.103.– P.1124.

10. Dinarello C.A. Targeting interleukin 18 with interleukin 18 binding protein // Ann. Rheum. Dis. — 2000.– Vol. 59.– P.17–20.

11. Fehniger T.A., Shah M.H., Turner M.J., VanDeusen J.B., Whitman S.P., Cooper M.A., Suzuki K., Wechser M., Goodsaid F., Caligiuri M.A. Differential cytokine and chemokine gene expression by human NK cells following activation with IL–18 or IL–15 in combination with IL–12: implications for the innate immune response // J. Immunol.– 1999.– Vol.162.– P. 4511–20.

12. Fujimori Y., Yoshimoto T., Matsui K., Tsutsui H., Okamoto T., Kashiwamura S., Hada T., Okamura H., Kakishita E., Hara H., Nakanishi K. Increased pression of interleukin–18 receptor on T lymphocytes in patients with acute graft–versus–host disease after allogeneic bone marrow transplantation // J. Interferon Cytokine Res.– 2002.– Vol.22.– P. 751–4.

13. Fukami T., Miyazaki E., Matsumoto T., Kumamoto T., Tsuda T. Elevated expression of interleukin18 in the granulomatous lesions of muscular sarcoidosis // Clin. Immuno.– 2001.– Vol.101.– P.12–20.

14. Gu Y., Kuida K., Tsutsui H., Ku G., Hsiao K., Fleming M.A., Hayashi N., Higashino K., Okamura H., Nakanishi K., Kurimoto M., Tanimoto T., Flavell R.A., Sato V., Harding M.W., Livingston D.J., Su M.S. Activation of interferon–gamma inducing factor mediated by interleukin–1beta converting enzyme // Science.– 1997.– Vol.275.– P. 206–9.

15. Hashimoto W., Tanaka F., Robbins P.D., Taniguchi M., Okamura H., Lotze M.T., Tahara H. Natural killer, but not natural killer T, cells play a necessary role in the promotion of an innate antitumor response induced by IL–18 // Int. J. Cancer.– 2003.– Vol.103.– P.508–13.

16. Heinzmann A., Gerhold K., Ganter K., Kurz T., Schuchmann L., Keitzer R., Berner R., Deichmann K.A. Association study of polymorphisms within interleukin–18 in juvenile idiopathic arthritis and bronchial asthma // Allergy.– 2004.– Vol.59.– P. 845–9.

17. Higa S., Hirano T., Mayumi M., Hiraoka M., Ohshima Y., Nambu M., Yamaguchi E., Hizawa N., Kondo N., Matsui E., Katada Y., Miyatake A., Kawase I., Tanaka T. Association between interleukin–18 gene polymorphism 105A/C and asthma // Clin. Exp. Allergy.– 2003.– Vol.33.– P. 1097–102.

18. Hofstra C.L., Van Ark I., Hofman G., Kool M., Nijkamp F.P., Van Oosterhout A.J. Prevention of Th2like cell responses by coadministration of IL–12 and IL18 is associated with inhibition of antigen–induced airway hyperresponsiveness, eosinophilia, and serum IgE levels // J. Immunol.– 1998.– Vol.161.– P. 5054–60.

19. Hong T.P., Andersen N.A., Nielsen K., Karlsen A.E., Fantuzzi G., Eizirik D.L., Dinarello C.A., Mandrup–Poulsen T. Interleukin–18 mRNA, but not interleukin18 receptor mRNA, is constitutively expressed in islet beta–cells and up–regulated by interferon–gamma // Eur. Cytokine Netw. – 2000. – Vol. 11. – P.193–205.

20. Hoshino T., Wiltrout R.H., Young H.A. IL–18 is a potent coinducer of IL–13 in NK and T cells: a new potential role for IL–18 in modulating the immune response // J. Immunol. – 1999. – Vol.162. – P.5070–7.

21. Hunter C.A., Timans J., Pisacane P., Menon S., Cai G., Walker W., Aste–Amezaga M., Chizzonite R., Bazan J.F., Kastelein R.A. Comparison of the effects of interleukin–1 alpha, interleukin–1 beta and interferongamma–inducing factor on the production of interferon–gamma by natural killer // Eur. J. Immunol. – 1997. – Vol. 27. – P. 2787–92.

22. Ide A., Kawasaki E., Abiru N., Sun F., Kobayashi M., Fukushima T., Takahashi R., Kuwahara H., Kita A., Oshima K., Uotani S., Yamasaki H., Yamaguchi Y., Eguchi K. Association between IL–18 gene promoter polymorphisms and CTLA–4 gene 49A/G polymorphism in Japanese patients with type 1 diabetes // J. Autoimmun. – 2004. – Vol. 22. – P. 73–8.

23. Janssen R., Grutters J.C., Ruven H.J., Zanen P., Sato H., Welsh K.I., du Bois R.M., van den Bosch J.M. No association between interleukin–18 gene polymorphisms and haplotypes in Dutch sarcoidosis patients / / Tissue Antigens. – 2004. – Vol.63. – P.578–83.

24. Kalina U., Ballas K., Koyama N., Kauschat D., Miething C., Arnemann J., Martin H., Hoelzer D., Ottmann O.G. Genomic organization and regulation of the human interleukin–18 gene // Scand. J. Immunol. — 2000. – Vol.52. – P.525–30.

25. Kalina U., Kauschat D., Koyama N., Nuernberger H., Ballas K., Koschmieder S., Bug G., Hofmann W.K., Hoelzer D., Ottmann O.G. IL–18 activates STAT3 in the natural killer cell line 92, augments cytotoxic activity, and mediates IFN–gamma production by the stress kinase p38 and by the extracellular regulated kinases p44erk–1 and p42erk–21 // J. Immunol. – 2000. — Vol. 165. – P.1307–13.

26. Kashiwamura S., Ueda H., Okamura H. Roles of interleukin–18 in tissue destruction and compensatory reactions // J. Immunother. – 2002. – Vol.25, Suppl. 1. — P. 4–11.

27. Kim Y.M., Talanian R.V., Li J., Billiar T.R. Nitric oxide prevents IL–1beta and IFN–gamma–inducing factor (IL–18) release from macrophages by inhibiting caspase–1 (IL–1beta–converting enzyme) // J. Immunol. – 1998. – Vol. 161. – P. 4122–8.

28. Kim S.H., Eisenstein M., Reznikov L., Fantuzzi G., Novick D., Rubinstein M., Dinarello C.A. Structural requirements of six naturally occurring isoforms of the IL–18 binding protein to inhibit IL–18 // Proc. Natl.Acad. Sci. U S A. – 2000.– Vol. 97.– P.1190–5.

29. Kinjo Y., Kawakami K., Uezu K., Yara S., Miyagi K., Koguchi Y., Hoshino T., Okamoto M., Kawase Y., Yokota K., Yoshino K., Takeda K., Akira S., Saito A. Contribution of IL–18 to Th1 response and host defense against infection by Mycobacterium tuberculosis: a comparative study with IL–12p40 // J. Immunol. – 2002. – Vol. 169. – P. 323–9.

30. Klein S.A., Ottmann O.G., Ballas K., Dobmeyer T.S., Pape M., Weidmann E., Hoelzer D., Kalina U. Quantification of human interleukin 18 mRNA expression by competitive reverse transcriptase polymerase chain reaction // Cytokine. – 1999. – Vol. 11. – P. 451–8.

31. Kohno K., Kataoka J., Ohtsuki T., Suemoto Y., Okamoto I., Usui M., Ikeda M., Kurimoto M. IFN–gamma–inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL–12 // J. Immunol.– 1997. — Vol.158.– P. 1541–50.

32. Kruse S., Kuehr J., Moseler M., Kopp M.V., Kurz T., Deichmann K.A., Foster P.S., Mattes J. Polymorphisms in the IL 18 gene are associated with specific sitization to common allergens and allergic rhinitis // J. Allergy Clin. Immunol.– 2003.– Vol.111.– P.117–22.

33. Kunikata T., Torigoe K., Ushio S., Okura T., Ushio C., Yamauchi H., Ikeda M., Ikegami H., Kurimoto M. Constitutive and induced IL–18 receptor expression by various peripheral blood cell subsets as determined by anti–hIL–18R monoclonal antibody // Cell Immunol.– 1998.– Vol.189.– P.135–43.

34. Lauwerys B.R., Renauld J.C., Houssiau F.A Synergistic proliferation and activation of natural killer cells by interleukin 12 and interleukin 18 // Cytokine.– 1999.– Vol. 11.– P. 822–30.

35. Matsui K., Yoshimoto T., Tsutsui H., Hyodo Y., Hayashi N., Hiroishi K., Kawada N., Okamura H., Nakanishi K., Higashino K. Propionibacterium acnes treatment diminishes CD4+ NK1.1+ T cells but induces type I T cells in the liver by induction of IL–12 and IL–18 production from Kupffer cells // J. Immunol.– 1997.– Vol.159.– P. 97–106.

36. McDaniel O.D., Yamout S., Aru G., Moore C.K. IL–18 gene polymorphism and expression correlates with coronary vasculopathy following transplantation // Hum. Immunol.– 2003.– Vol.64.– P.10.

37. Merendino R.A., Di Pasquale G., Sturniolo G.C., Ruello A., Albanese V., Minciullo P.L., Di Mauro S., Gangemi S. Relationship between IL–18 and sICAM–1 serum levels in patients affected by coeliac disease: preliminary considerations // Immunol. Lett.– 2003.– Vol. 85.– P. 257–60.

38. Micallef M.J., Ohtsuki T., Kohno K., Tanabe F., Ushio S., Namba M., Tanimoto T., Torigoe K., Fujii M., Ikeda M., Fukuda S., Kurimoto M. Interferon–gammainducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin–12 for interferon–gamma production // Eur. J. Immunol.– 1996.– Vol. 26.– P. 1647–51.

39. Monteforte G.M., Takeda K., Rodriguez–Sosa M., Akira S., David J.R., Satoskar A.R. Genetically resistant mice lacking IL–18 gene develop Th1 response and control cutaneous Leishmania major infection // J. Immunol. – 2000.– Vol.164.– P. 5890–3.

40. Morel J.C., Park C.C., Zhu K., Kumar P., Ruth J.H., Koch A.E. Signal transduction pathways involved in rheumatoid arthritis synovial fibroblast interleukin18–induced vascular cell adhesion molecule–1 expression // J. Biol. Chem.– 2002.– Vol. 277.– P. 34679–91.

41. Naik S.M., Cannon G., Burbach G.J., Singh S.R., Swerlick R.A., Wilcox J.N., Ansel J.C., Caughman S.W. Human keratinocytes constitutively express interleukin–18 and secrete biologically active interleukin–18 after treatment with pro–inflammatory mediators and dinitrochlorobenzene // J. Invest. Dermatol. – 1999. — Vol.113.– P. 766–72.

42. Nakamura K., Okamura H., Wada M., Nagata K., Tamura T. Endotoxin–induced serum factor that stimulates gamma interferon production // Infect. Immun.– 1989.– Vol.57.– P. 590–5.

43. Nakanishi K., Yoshimoto T., Tsutsui H., Okamura H. Interleukin–18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu // Cytokine Growth Factor Rev. — 2001. – Vol.12.– P. 53–72.

44. Nolan K.F., Greaves D.R., Waldmann H. The human interleukin 18 gene IL18 maps to 11q22.2–q22.3closely linked to the DRD2 gene locus and distinct from mapped IDDM loci // Genomics.– 1998.– Vol.51.– P. 161–3.

45. Nolsoe R.L., Pociot F., Novick D., Rubinstein M., Kim S.H., Dinarello C.A., Mandrup–Poulsen T. Mutation scan of a type 1 diabetes candidate gene: the human interleukin–18 binding protein gene // Ann .N. Y. Acad .Sci. – 2003 .– Vol. 1005.– P. 332–9.

46. Nomaguchi H., Jahan N., Mandal B.C., Yogi Y., Kawatsu K., Yoshizawa Y., Okamura H., Makino M. IL–12 and IL–18 synergistically induce the bactericidal activity of murine peritoneal cells against M. leprae // Nihon Hansenbyo Gakkai Zasshi.– 2001.– Vol. 70. — P. 113–9.

47. Novick D., Kim S.H., Fantuzzi G., Reznikov L.L., Dinarello C.A., Rubinstein M. Interleukin–18 binding protein: a novel modulator of the Th1 cytokine response // Immunity.– 1999.– Vol. 10.– P. 127–36.

48. Novick D., Schwartsburd B., Pinkus R. Suissa D., Belzer I., Sthoeger Z., Keane W.F., Chvatchko Y., Kim S.H., Fantuzzi G., Dinarello C.A., Rubinstein M. A novel IL–18BP ELISA shows elevated serum IL18BP in sepsis and extensive decrease of free IL–18 // Cytokine.– 2001.– Vol. 14.– P. 334–42.

49. Ogura T., Ueda H., Hosohara K., Tsuji R., Nagata Y., Kashiwamura S., Okamura H. Interleukin–18 stimulates hematopoietic cytokine and growth factor formation and augments circulating granulocytes inmice // Blood.– 2001.– Vol. 98.– P. 2101–7.

50. Ohkusu K., Yoshimoto T., Takeda K., Ogura T., Kashiwamura S., Iwakura Y., Akira S., Okamura H., Nakanishi K. Potentiality of interleukin–18 as a useful reagent for treatment and prevention of Leishmania major infection // Infect. Immun. – 2000.– Vol. 68.– P. 2449–56.

51. Okamura H., Kashiwamura S., Tsutsui H., Yoshimoto T., Nakanishi K. Regulation of interferongamma production by IL–12 and IL–18 // Curr Opin Immunol.– 1998.– Vol. 10.– P. 259–64.

52. Okamura H., Nagata K., Komatsu T., Tanimoto T., Nukata Y., Tanabe F., Akita K., Torigoe K., Okura T., Fukuda S. et al. A novel costimulatory factor for gamma interferon induction found in the livers of mice causes endotoxic shock // Infect. Immun. – 1995. – Vol. 63.– p. 3966–72.

53. Okamura H., Tsutsi H., Komatsu T., Yutsudo M., Hakura A., Tanimoto T., Torigoe K., Okura T., Nukada Y., Hattori K., et al. Cloning of a new cytokine that induces IFN– gamma production by T cells // Nature.– 1995.– Vol. 378.– P. 88–91.

54. Osaki T., Hashimoto W., Gambotto A., Okamura H., Robbins P.D., Kurimoto M., Lotze M.T., Tahara H. Potent antitumor effects mediated by local expression of the mature form of the interferon–gamma inducing factor, interleukin–18 (IL–18) // Gene Ther.– 1999. — Vol. 6.– P. 808–15.

55. Prinz M., Hanisch U.K. Murine microglial cells produce and respond to interleukin–18 // J. Neurochem.– 1999.– Vol. 72.– p. 2215–8.

56. Puren A.J., Fantuzzi G., Gu Y., Su M.S., Dinarello C.A. Interleukin–18 (IFNgamma–inducing factor) induces IL–8 and IL–1beta via TNFalpha production from non–CD14+ human blood mononuclear cells // J. Clin. Invest. – 1998.– Vol. 101.– P. 711–21.

57. Puren A.J., Razeghi P., Fantuzzi G., Dinarello C.A. Interleukin–18 enhances lipopolysaccharide–induced interferon–gamma production in human whole blood cultures // J. Infect. Dis. – 1998. – Vol. 178. – P. 1830–4.

58. Robinson D., Shibuya K., Mui A., Zonin F., Murphy E., Sana T., Hartley S.B., Menon S., Kastelein R., Bazan F., O’Garra A. IGIF does not drive Th1 development but synergizes with IL–12 for interferongamma production and activates IRAK and NfkappaB // Immunity.– 1997.– Vol. 7.– P. 571–81.

59. Rothe H., Jenkins N.A., Copeland N.G., Kolb H. Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2 // J. Clin. Invest. –1997. – Vol. 99.– P. 469–74.

60. Son Y.I., Dallal R.M., Mailliard R.B., Egawa S., Jonak Z.L., Lotze M.T. Interleukin–18 (IL–18) synergizes with IL–2 to enhance cytotoxicity, interferongamma production, and expansion of natural killer cells // Cancer Res.– 2001.– Vol. 61.– P. 884–8.

61. Stober D., Schirmbeck R., Reimann J. IL–12/IL18–dependent IFN–gamma releases by murine dendritic cells // J. Immunol. – 2001.– Vol. 167.– P. 957–65.

62. Stoll S., Muller G., Kurimoto M., Saloga J., Tanimoto T., Yamauchi H., Okamura H., Knop J., Enk A.H. Production of IL–18 (IFN–gamma–inducing factor) messenger RNA and functional protein by murine keratinocytes // J. Immunol.– 1997.– Vol. 159.– P. 298302.

63. Sugawara S., Uehara A., Nochi T., Yamaguchi T., Ueda H., Sugiyama A., Hanzawa K., Kumagai K., Okamura H., Takada H. Neutrophil proteinase 3–mediated induction of bioactive IL–18 secretion by human oral epithelial cells // J. Immunol.– 2001.– Vol. 167.– P. 6568–75.

64. Takeda K., Tsutsui H., Yoshimoto T., Adachi O., Yoshida N., Kishimoto T., Okamura H., Nakanishi K., Akira S. Defective NK cell activity and Th1 response in IL–18–deficient mice // Immunity.– 1998.– Vol. 8. — P. 383–90.

65. Takeuchi M., Nishizaki Y., Sano O., Ohta T., Ikeda M., Kurimoto M. Immunohistochemical and immuno–electron–microscopic detection of interferongamma–inducing factor («interleukin–18») in mouse intestinal epithelial cells // Cell Tissue Res.– 1997. — Vol. 289. – P. 499–503.

66. Tamura K., Fukuda Y., Sashio H., Takeda N., Bamba H., Kosaka T., Fukui S., Sawada K., Tamura K., Satomi M., Yamada T., Yamamura T., Yamamoto Y., Furuyama J., Okamura H., Shimoyama T. IL18 polymorphism is associated with an increased risk of Crohn’s disease // J. Gastroenterol.– 2002.– Vol. 37.– P. 111–6.

67. Tan J., Crucian B.E., Chang A.E., Aruga E., Aruga A., Dovhey S.E., Tanigawa K., Yu H. Interferon–gamma–inducing factor elicits antitumor immunity in association with interferon–gamma production // J. Immunother.– 1998.– Vol. 21.– P. 48–55.

68. Taub D.D., Cox G.W. Murine Th1 and Th2 cell clones differentially regulate macrophage nitric oxide production // J Leukoc Biol .– 1995.– Vol. 58.– P. 80–9.

69. Tomura M., Maruo S., Mu J., Zhou X.Y., Ahn H.J., Hamaoka T., Okamura H., Nakanishi K., Clark S., Kurimoto M., Fujiwara H. Differential capacities of CD4+, CD8+, and CD4–CD8– T cell subsets to express IL–18 receptor and produce IFN–gamma in response toIL–18 // J. Immunol.– 1998.– Vol. 160.– P. 3759–65.

70. Tomura M., Zhou X.Y., Maruo S., Ahn H.J., Hamaoka T., Okamura H., Nakanishi K., Tanimoto T., Kurimoto M., Fujiwara H. A critical role for IL–18 in the proliferation and activation of NK1.1+ CD3– cells // J. Immunol.– 1998.– Vol. 160.– P. 4738–46.

71. Tone M., Thompson S.A., Tone Y., Fairchild P.J., Waldmann H. Regulation of IL–18 (IFN–gamma–inducing factor) gene expression // J. Immunol. – 1997. – Vol. 159. – P. 6156–63.

72. Torigoe K., Ushio S., Okura T., Kobayashi S.Taniai M., Kunikata T., Murakami T., Sanou O., Kojima H., Fujii M., Ohta T., Ikeda M., Ikegami H., Kurimoto M. Purification and characterization of the humaninterleukin–18 receptor // J. Biol. Chem.– 1997. – Vol. 272. – P. 25737–42.

73. Tsuji–Takayama K., Aizawa Y., Okamoto I., Kojima H., Koide K., Takeuchi M., Ikegami H., Ohta T., Kurimoto M. Interleukin–18 induces interferon–gamma production through NF–kappaB and NFAT activation in murine T helper type 1 cells // Cell Immunol. 1999. – Vol. 196. – P. 41–50.

74. Tsutsui H., Matsui K., Okamura H., Nakanishi K. Pathophysiological roles of interleukin–18 in inflammatory liver diseases // Immunol. Rev. – 2000. – Vol. 174. – P. 192–209.

75. Tsutsui H., Nakanishi K., Matsui K., Higashino K., Okamura H., Miyazawa Y., Kaneda K. IFN–gamma–inducing factor up–regulates Fas ligandmediated cytotoxic activity of murine natural killer cell clones // J. Immunol. – 1996. – Vol. 157. – P.3967–73.

76. Udagawa N., Horwood N.J., Elliott J., Mackay A., Owens J., Okamura H., Kurimoto M., Chambers T.J. Martin T.J., Gillespie M.T. Interleukin–18 (interferongamma–inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony–stimulating factor and not via interferon–gamma to inhibit osteoclast formation // J. Exp. Med.– 1997. – Vol. 185. – P. 1005–12.

77. Ushio S., Namba M., Okura T., Hattori K., Nukada Y., Akita K., Tanabe F., Konishi K., Micallef M., Fujii

78. M., Torigoe K, Tanimoto T., Fukuda S., Ikeda M., Okamura H., Kurimoto M. Cloning of the cDNA for human IFN–gamma–inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein // J. Immunol. – 1996. – Vol. 156. – P. 4274–9.

79. Wei X.Q., Leung B.P., Arthur H.M., McInnes I.B., Liew F.Y. Reduced incidence and severity of collagen–induced arthritis in mice lacking IL–18 // J. Immunol. – 2001. – Vol.166. – P. 517–21.

80. Wei X.Q., Leung B.P., Niedbala W., Piedrafita D., Feng G.J., Sweet M., Dobbie L., Smith A.J., Liew F.Y. Altered immune responses and susceptibility to Leishmania major and Staphylococcus aureus infection in IL–18–deficient mice // J. Immunol. – 1999. – Vol. 163. – P. 2821–8.

81. Xiang Y., Moss B. IL–18 binding and inhibition of interferon gamma induction by human poxvirus–encoded proteins // Proc. Natl. Acad. Sci. U S A. – 1999. – Vol. 96. – P. 11537–42.

82. Xu D., Chan W.L., Leung B.P., Hunter D.Schulz K., Carter R.W., McInnes I.B., Robinson J.H.Liew F.Y. Selective expression and functions of leukin 18 receptor on T helper (Th) type 1 but not Th2 cells // J. Exp. Med.– 1998. – Vol. 188. – P. 1485–92.

83. Yakushenko E.V., Lopatnikova J.A, Khrapov E.A., Filipenko M.L., Pustoshilova N.M., Zakabunin A.L., Sennikov S.V., Kozlov V.A.. Biological and specific activity of recombinant human Interleukin–18 // Cytokine network, and Regulatory Cells. – Medimond, Inernational proceedings, – 2004.– P. 423–428.

84. Yoshimoto T., Mizutani H., Tsutsui H., Noben–Trauth N., Yamanaka K., Tanaka M., Izumi S., Okamura H., Paul W.E., Nakanishi K. IL–18 induction of IgE: dependence on CD4+ T cells, IL–4 and STAT6 // Nat. Immunol. – 2000. – Vol. 1. – P. 132–7.

85. Yoshimoto T., Okamura H, Tagawa Y.I., Iwakura Y., Nakanishi K. Interleukin 18 together with interleukin 12 inhibits IgE production by induction of interferon–gamma production from activated B cells // Proc. Natl. Acad. Sci. U S A. – 1997. – Vol. 94. – P. 3948–53.

86. Yoshimoto T., Takeda K., Tanaka T., Ohkusu K., Kashiwamura S., Okamura H., Akira S., Nakanishi K. IL–12 up–regulates IL–18 receptor expression on Tcells, Th1 cells, and B cells: synergism with IL–18 for IFN–gamma production // J. Immunol. – 1998. – Vol. 161. – P. 3400–7.

87. Yoshimoto T., Tsutsui H., Tominaga K., Hoshino K., Okamura H., Akira S., Paul W.E., Nakanishi K. IL–18, although antiallergic when administered with IL–12, stimulates IL–4 and histamine release by basophils // Proc. Natl. Acad Sci. U S A. – 1999. – Vol. 96. — P. 13962–6.


Для цитирования:


Якушенко Е.В., Лопатникова Ю.А., Сенников С.В. ИНТЕРЛЕЙКИН–18 И ЕГО РОЛЬ В ИММУННОМ ОТВЕТЕ. Медицинская иммунология. 2005;7(4):355-364. https://doi.org/10.15789/1563-0625-2005-4-355-364

For citation:


Yakushenko E.V., Lopatnikova J.A., Sennikov S.V. IL–18 AND IMMUNITY. Medical Immunology (Russia). 2005;7(4):355-364. (In Russ.) https://doi.org/10.15789/1563-0625-2005-4-355-364

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