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Медицинская иммунология

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ИНТЕРЛЕЙКИН–18 И ЕГО РОЛЬ В ИММУННОМ ОТВЕТЕ

https://doi.org/10.15789/1563-0625-2005-4-355-364

Аннотация

Резюме. Интерлейкин–18 один из основных иммунорегуляторных цитокинов, индуцирующий продукцию IFNγ, что обуславливает его важное значение как фактора противоинфенкционной и противоопухолевой защиты организма. В представленном обзоре рассматриваются молекулярно–генетические и биохимические характеристики IL–18. Приведены данные о клетках продуцентах, строении рецептора и IL–18 связывающего белка, пути передачи сигнала в клетке. Кроме того, рассматриваются основные иммунорегуляторные эффекты IL–18.

Об авторах

Е. В. Якушенко
ГУ НИИ Клинической Иммунологии СО РАМН, Новосибирск
Россия
г. Новосибирск, ул. Ядринцевская, д. 14


Ю. А. Лопатникова
ГУ НИИ Клинической Иммунологии СО РАМН, Новосибирск
Россия


С. В. Сенников
ГУ НИИ Клинической Иммунологии СО РАМН, Новосибирск
Россия


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Рецензия

Для цитирования:


Якушенко Е.В., Лопатникова Ю.А., Сенников С.В. ИНТЕРЛЕЙКИН–18 И ЕГО РОЛЬ В ИММУННОМ ОТВЕТЕ. Медицинская иммунология. 2005;7(4):355-364. https://doi.org/10.15789/1563-0625-2005-4-355-364

For citation:


Yakushenko E.V., Lopatnikova J.A., Sennikov S.V. IL–18 AND IMMUNITY. Medical Immunology (Russia). 2005;7(4):355-364. (In Russ.) https://doi.org/10.15789/1563-0625-2005-4-355-364

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