ИНТЕРЛЕЙКИН–18 И ЕГО РОЛЬ В ИММУННОМ ОТВЕТЕ
https://doi.org/10.15789/1563-0625-2005-4-355-364
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Аннотация
Резюме. Интерлейкин–18 один из основных иммунорегуляторных цитокинов, индуцирующий продукцию IFNγ, что обуславливает его важное значение как фактора противоинфенкционной и противоопухолевой защиты организма. В представленном обзоре рассматриваются молекулярно–генетические и биохимические характеристики IL–18. Приведены данные о клетках продуцентах, строении рецептора и IL–18 связывающего белка, пути передачи сигнала в клетке. Кроме того, рассматриваются основные иммунорегуляторные эффекты IL–18.
Об авторах
Е. В. Якушенко
ГУ НИИ Клинической Иммунологии СО РАМН, Новосибирск
Россия
г. Новосибирск, ул. Ядринцевская, д. 14
Россия
г. Новосибирск, ул. Ядринцевская, д. 14
Ю. А. Лопатникова
ГУ НИИ Клинической Иммунологии СО РАМН, Новосибирск
Россия
Россия
С. В. Сенников
ГУ НИИ Клинической Иммунологии СО РАМН, Новосибирск
Россия
Россия
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Для цитирования:
Якушенко Е.В., Лопатникова Ю.А., Сенников С.В. ИНТЕРЛЕЙКИН–18 И ЕГО РОЛЬ В ИММУННОМ ОТВЕТЕ. Медицинская иммунология. 2005;7(4):355-364. https://doi.org/10.15789/1563-0625-2005-4-355-364
For citation:
Yakushenko E.V., Lopatnikova J.A., Sennikov S.V. IL–18 AND IMMUNITY. Medical Immunology (Russia). 2005;7(4):355-364. (In Russ.) https://doi.org/10.15789/1563-0625-2005-4-355-364
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ISSN 1563-0625 (Print)
ISSN 2313-741X (Online)
ISSN 2313-741X (Online)
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