IN VITRO ANALYSIS OF MIGRATION ACTIVITY OF ENCEPHALYTOGENIC T CEL
https://doi.org/10.15789/1563-0625-2010-6-565-568
Abstract
Experimental autoimmune encephalomyelitis in an adoptive transfer model is caused by injecting animal with activated T cells specific for a CNS antigen, e.g., basic myelin protein. Development of autimmune inflammation in such a model is connected with changed functional stateof encephalytogenic (EG) T cells in the coure of disease progression, as reflected by changes in their activation, proliferation and motility levels. Present work describes an original technique allowing for in vitro analysis of encephalytogenic T cell motility, and studying effects of certain compomemts of extracellular matrix upon migration and functional activities of EG T cells.
About the Authors
M. A. Nosov
НИИ экспериментальной медицины СЗО РАМН, Санкт-Петербург
Институт регенерационной медицины, Национальный Университет Ирландии, Голуэй, Ирландия
Russian Federation
Russian Federation
E. A. Korneva
НИИ экспериментальной медицины СЗО РАМН, Санкт-Петербург
Russian Federation
Russian Federation
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Review
For citations:
Nosov M.A., Korneva E.A. IN VITRO ANALYSIS OF MIGRATION ACTIVITY OF ENCEPHALYTOGENIC T CEL. Medical Immunology (Russia). 2010;12(6):565-568. (In Russ.) https://doi.org/10.15789/1563-0625-2010-6-565-568
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