POSSIBLE ROLE OF PROBIOTIC MICROORGANISMS OF BIFIDOBACTERIUM AND LACTOBACILLUS GENUS IN PATHOGENESIS OF AUTOIMMUNE THYROID DISEASES
https://doi.org/10.15789/1563-0625-2010-1-2-71-80
Abstract
It was revealed, that, in blood samples of the patients with autoimmune thyroid diseases, serum antibodies against cell-free fraction of Bifidobacterium bifidum 791 and Lactobacillus plantarum B-01 were detected, respectively, in 71 and 63% of cases, that being two-fold higher than appropriate frequencies in healthy blood donors. An evidence was obtained that presence of some components specifically reacting with autoantibodies against thyroid peroxidase and thyroglobulin on the surface of the microorganisms cells and competing for binding of these immunoglobulins with thyroid antigens. One may also suggest a presence of bacterial components, interacting with thyroid peroxidase. The data obtained let us suggest that probiotic microorganisms of Bifidobacterium and Lactobacillus genus could take part in pathogenesis of autoimmune thyroid diseases, by means of molecular mimicry mechanisms.
About the Authors
E. P. Kiseleva
Институт биоорганической химии НАН Беларуси, г. Минск, Республика Беларусь
Russian Federation
Russian Federation
O. V. Tsyganova
Институт биоорганической химии НАН Беларуси, г. Минск, Республика Беларусь
Russian Federation
Russian Federation
K. I. Mikhailopulo
Институт биоорганической химии НАН Беларуси, г. Минск, Республика Беларусь
Russian Federation
Russian Federation
O. V. Sviridov
Институт биоорганической химии НАН Беларуси, г. Минск, Республика Беларусь
Russian Federation
Russian Federation
Y. E. Demidchic
Государственное учреждение образования «Белорусская медицинская академия последипломного
образования», г. Минск, Республика Беларусь
Russian Federation
Russian Federation
A. V. Izhik
Институт микробиологии НАН Беларуси, г. Минск, Республика Беларусь
Russian Federation
Russian Federation
Y. A. Knirel
Институт органической химии РАН, Москва, Россия
Russian Federation
Russian Federation
G. I. Novik
Институт микробиологии НАН Беларуси, г. Минск, Республика Беларусь
Russian Federation
Russian Federation
References
1. Вашкевич И.И., Ермоленко М.Н., Киселева Е.П., Михайлопуло К.И., Свиридов О.В. Выделение интактной и обработанной трипсином тиропероксидазы для технологии иммуноанализа//Биотехнология. -1999. -Т. 3. -С. 43-55.
2. Цыганова О.В., Киселева Е.П., Вашкевич И.И., Прядко А.Г., Свиридов О.В. Характеристика иммуноаффинной хроматографии и новый метод получения тиропероксидазы из субклеточных фракций щитовидной железы//Прикладная биохимия и микробиология. -2006. -T. 42. -C. 236-246.
3. Цыганова О.В., Киселева Е.П., Вашкевич И.И., Прядко А.Г., Свиридов О.В. Характеристика моноклональных антител к тиропероксидазе человека для использования в иммуноаффинной хроматографии и иммуноанализе//Прикладная биохимия и микробиология. -2006. -T. 42. -C. 98-105.
4. Цыганова О.В., Киселева Е.П., Вашкевич И.И., Свиридов О.В. Выделение аутоантител к тиропероксидазе человека антиген-аффинной хроматографией и их применение в иммуноанализе//Вес. Нац. акад. навук. Беларусi. Сер. хiм. навук. -2006. -T. 1. -C. 64-71.
5. Цыганова О.В., Киселева Е.П., Здоровенко Э.Л., Новик Г.И. Роль молекулярной мимикрии в этиологии и патогенезе аутоиммунных заболеваний щитовидной железы: антигены микроорганизмов и тироглобулин//Материалы конференции «Молодежь в науке -2009». -Мн., 2009 (в печати).
6. Alberti G. Noncommunicable diseases: tomorrow’s pandemics//Bull. World health organ. -2001. -Vol. 79. -P. 907.
7. Beever K., Bradbury J., Phillips D., McLachlan S.M., Pegg C., Goral A., Overbeck W., Feifel G., Smith B.R. Highly sensitive assays of autoantibodies to thyroglobulin and to thyroid peroxidase//Clin. Chem. -1989. -Vol. 35. -P. 1949-1954.
8. Ebringer A., Rashid T., Wilson C. Bovine spongiform encephalopathy, multiple sclerosis, and creutzfeldt-jakob disease are probably autoimmune diseases evoked by Acinetobacter bacteria//Ann. N. Y. Acad. Sci. -2005. -Vol. 1050. -P. 417-428.
9. Gill H.S., Rutherfurd K.J., Pr21. Tomer Y., Davies T.F. Infection, thyroid disease, and autoimmunity // Endocr. Rev. – 1993. –Vol. 14. – P. 107-120.
10. Grogan J.L., Kramer A., Nogai A., Dong L., Ohde M., Schneider-Mergener J., Kamradt T. Cross-reactivity of myelin basic protein-specific T cells with multiple microbial peptides: experimental autoimmune encephalomyelitis induction in TCR transgenic mice//J. Immunol. -1999. -Vol. 163. -P. 3764-3770.
11. Kaufmann P., Pfefferkorn A., Teuber M., Meile L. Identification and quantification of Bifidobacterium species isolated from food with genus-specific 16S rRNA-targeted probes by colony hybridization and PCR//Appl. Environ. Microbiol. -1997. -Vol. 63. -P. 1268-1273.
12. Marcocci C., Chiovato L. The epidemiology of thyroid diseases//The thyroid: a fundamental and clinical text. -Philadelphia: Lippincott Williams & Wilkins, 2000. -P. 414-431.
13. Mennink-Kersten M.A., Ruegebrink D., Klont R.R., Warris A., Gavini F., Op den Camp H.J., Verweij P.E. Bifidobacterial lipoglycan as a new cause for false-positive platelia Aspergillus enzyme-linked immunosorbent assay reactivity//J. Clin.Microbiol. -2005. -Vol. 43. -P. 3925-3931.
14. Napalkov N. Prevention and Control of Noncommunicable diseases//Encyclopedia of Life Support Systems. -UNESCO, 2002.
15. Oleszak E.L., Chang J.R., Friedman H., Katsetos C.D., Platsoucas C.D. Theiler’s virus infection: a model for multiple sclerosis//Clin. Microbiol. Rev. -2004. -Vol. 17. -P. 174-207.
16. Rapoport B., McLachlan S.M. Thyroid autoimmunity//J. Clin. Invest. -2001. -Vol. 108. -P. 1253-1259.
17. Ruf J., Feldt-Rasmussen U., Hegedus L., Ferrand M., Carayon P. Bispecific thyroglobulin and thyroperoxidase autoantibodies in patients with various thyroid and autoimmune diseases//J. Clin.Endocrinol. Metab. -1994. -Vol. 79. -P. 1404 -1409.
18. Shakib F., Stanworth D.R. Human IgG subclasses in health and disease (A review)//Ric. Clin. Lab. -1980. -Vol. 10. -P. 561-580.
19. Stassi G., De Maria R. Autoimmune thyroid disease: new models of cell death in autoimmunity//Nat. Rev. Immunol. -2002. -Vol. 2. -P. 195-204.
20. Steinbuch M., Audran R. The isolation of IgG from mammalian sera with the aid of caprylic acid//Arch. Biochem.Biophys. -1969. -Vol. 134. - P. 279-284.
21. Tomer Y., Davies T.F. Infection, thyroid disease, and autoimmunity // Endocr. Rev. – 1993. – Vol. 14. – P. 107-120.
22. Vinderola C.G., Medici M., Perdigon G. Relationship between interaction sites in the gut, hydrophobicity, mucosal immunomodulating capacities and cell wall protein profiles in indigenous and exogenous bacteria // J. Appl. Microbiol. – 2004. – Vol. 96. – P. 230-243.
23. Volpe R. Immunology of human thyroid disease // Autoimmune diseases of the endocrine system. – Boca Raton: CRC. Press, 1990. – P. 73-239.
24. Weetman A.P., McGregor A.M. Autoimmune thyroid disease: further developments in our understanding // Endocr. Rev. – 1994. – Vol. 15. – P. 788-830.
25. Wilson M.B., Nakane P.K. Immunofluorescens and related staining techniques. – Amsterdam, 1978. – P. 215.
26. Zimmer K.P., Scheumann G.F., Bramswig J., Bocker W., Harms E., Schmid K.W. Ultrastructural localization of IgG and TPO in autoimmune thyrocytes referring to the transcytosis of IgG and the antigen presentation of TPO // Histochem. Cell. Biol. – 1997. – Vol. 107. – P. 115-120.
27. Zhou J.S., Gill H.S. Immunostimulatory probiotic Lactobacillus rhamnosus HN001 and Bifidobacterium lactis HN019 do not induce pathological inflammation in mouse model of experimental autoimmune thyroiditis // Int. J. Food Microbiol. – 2005. – Vol. 103. – P. 97-104.
Review
For citations:
Kiseleva E.P., Tsyganova O.V., Mikhailopulo K.I., Sviridov O.V., Demidchic Y.E., Izhik A.V., Knirel Y.A., Novik G.I. POSSIBLE ROLE OF PROBIOTIC MICROORGANISMS OF BIFIDOBACTERIUM AND LACTOBACILLUS GENUS IN PATHOGENESIS OF AUTOIMMUNE THYROID DISEASES. Medical Immunology (Russia). 2010;12(1-2):71-80. (In Russ.) https://doi.org/10.15789/1563-0625-2010-1-2-71-80
Views:
1034
Email this article 