CHARACTERISTICS OF CELLULAR AND SERUM COMPONENTS OF MUCO-SALIVARY IMMUNE COMPARTMENT IN MATURE, AGED, AND SENESCENT PERSONS

Аbstract. The objective of present study was to determine the immunological features of immune system aging in mucosa-associated lymphoid tissue (MALT) in the patients at different ages (mature, aging and old) observed at a dental unit. A study of cellular spectrum and humoral factors in salivary gland secretions has been performed in a group of 106 persons (35 to 90 years old). A number of age-dependent features of the immune profile were revealed for the mucous-salivary area, thus characterizing involution events within MALT structures. Among specific markers determining intensity of MALT-associated aging, a decreased percentage of viable immune cells (below 40%), along with the prevalence of the neutrophilic granulocytes in the salivary secretions (over 98%) (with increased expression of β2-integrins); decreased counts of mononuclear cells, i.e., mononuclear cells with low expression of CD11β adhesion molecules, B-lymhocytes, and Th-lymphocytes have been revealed. Alterations in serum factors included a general decrease in complement system activity (СН50) and anaphylotoxines (С3а,С5а); elevated protein, mucine, and IgМ levels. The revealed specific features of cellular and humoral immunity within MALT-associated muco-salivary zone may be considered as a normal response connected with natural aging processes. (Med. Immunol., 2011, vol. 13, N 2-3, pp 167-174)

aging, oral mucosa, immunocytes, immunoglobulins, complement, mucine

1. Банченко Г.В. Проблемы заболеваний СОП // Зубоврачебный вестник. – 1993. – № 1 (2). – С. 13-18.

2. Михайлов В.В., Русанова А.Г. К механизму трофических влияний слюнных желез на слизистую полости рта // Бюлл. экспер.биолог. – 1993. – № 2. – С. 139-140

3. Санникова Т.Е., Марчук Г.И., Романюха А.А., Яшин А.И. Старение системы иммунитета и динамика смертности. Анализ роли антиген-ной нагрузки // Успехи геронтологии. – 2003. – Т. 12. – С. 91-98.

4. Теплова С.Н., Коченгина С.А., Масленникова Н.П., Рахматулина Э.Х. Способ анализа популяционного состава иммунных клеток слюны с помощью метода проточной цитофлю ориметрии // Патент на изобретение № 2377568 от 23.05.2008.

5. Ткаченко Т.Б., Бобров А.П., Рыжак Г.А. Возрастные особенности слизистой оболочки полости рта // Успехи геронтологии. – 2007. – Т. 20, № 1. – С. 118-120.

6. Gavazzi G., Krause K.H. Ageing and infection // Lancet Infect Dis. – 2002. – Vol. 2 (11). – Р. 655.

7. Lamblin G., Roussel P. Airway mucincs and their role in defence against microorganisms // Resp. Med. – 1993. – Vol. 87. – P. 421-426.

8. Sonis S.T. A biological approach to mucositis // J. Support. Oncol. 2004. – 2 (1). – P. 21-32