FEATURES OF HSP70-2 AND HSP70-НОМ GENE POLYMORPHISM IN THE PATIENTS WITH A HISTORY OF MYOCARDIAL INFARCTION
https://doi.org/10.15789/1563-0625-2011-1-87-92
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Abstract
Аbstract. We have performed an analysis of associations between allelic polymorphisms of heat shock protein (HSP) genes, i.e., HSP70-2 1267А→G and HSP70-НОМ 2437Т→С in Caucasian patients with acute myocardial infarction (AMI) in anamnesis, along with evaluation of common risk factors for MI. Frequency of HSP70-HOM*TC heterozygous variant proved to be significantly higher in the group with Kettle body mass index (BMI) exceeding 25, as compared with a group of relatively healthy persons. By contrary, frequency of HSP70-HOM*CC homozygosity in the MI group with BMI > 25 was significantly lower, than among healthy persons. When comparing genotype frequencies among MI patients with BMI > 25 and those with BMI<25, significance of the differences are retained, both for HSP70-HOM*TC heterozygosity and HSP70-HOM*CC homozygous state. (Med. Immunol., 2011, vol. 13, N 1, pp 87-92)
About the Authors
A. V. Shevchenko
Учреждение Российской академии медицинских наук Научно-исследовательский институт клинической и экспериментальной лимфологии Сибирского отделения РАМН, г. Новосибирск
Russian Federation
Russian Federation
O. V. Golovanova
Учреждение Российской академии медицинских наук Научно-исследовательский институт клинической и экспериментальной лимфологии Сибирского отделения РАМН, г. Новосибирск
Russian Federation
Russian Federation
V. I. Konenkov
Учреждение Российской академии медицинских наук Научно-исследовательский институт клинической и экспериментальной лимфологии Сибирского отделения РАМН, г. Новосибирск
Russian Federation
Russian Federation
M. I. Voevoda
Учреждение Российской академии медицинских наук Научно-исследовательский институт терапии
Сибирского отделения РАМН, г. Новосибирск
Russian Federation
Russian Federation
V. N. Maximov
Учреждение Российской академии медицинских наук Научно-исследовательский институт терапии
Сибирского отделения РАМН, г. Новосибирск
Russian Federation
Russian Federation
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Review
For citations:
Shevchenko A.V., Golovanova O.V., Konenkov V.I., Voevoda M.I., Maximov V.N. FEATURES OF HSP70-2 AND HSP70-НОМ GENE POLYMORPHISM IN THE PATIENTS WITH A HISTORY OF MYOCARDIAL INFARCTION. Medical Immunology (Russia). 2011;13(1):87-92. (In Russ.) https://doi.org/10.15789/1563-0625-2011-1-87-92
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ISSN 2313-741X (Online)
ISSN 2313-741X (Online)
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