FEATURES OF HSP70-2 AND HSP70-НОМ GENE POLYMORPHISM IN THE PATIENTS WITH A HISTORY OF MYOCARDIAL INFARCTION
https://doi.org/10.15789/1563-0625-2011-1-87-92
Abstract
Аbstract. We have performed an analysis of associations between allelic polymorphisms of heat shock protein (HSP) genes, i.e., HSP70-2 1267А→G and HSP70-НОМ 2437Т→С in Caucasian patients with acute myocardial infarction (AMI) in anamnesis, along with evaluation of common risk factors for MI. Frequency of HSP70-HOM*TC heterozygous variant proved to be significantly higher in the group with Kettle body mass index (BMI) exceeding 25, as compared with a group of relatively healthy persons. By contrary, frequency of HSP70-HOM*CC homozygosity in the MI group with BMI > 25 was significantly lower, than among healthy persons. When comparing genotype frequencies among MI patients with BMI > 25 and those with BMI<25, significance of the differences are retained, both for HSP70-HOM*TC heterozygosity and HSP70-HOM*CC homozygous state. (Med. Immunol., 2011, vol. 13, N 1, pp 87-92)
About the Authors
A. V. Shevchenko
Учреждение Российской академии медицинских наук Научно-исследовательский институт клинической и экспериментальной лимфологии Сибирского отделения РАМН, г. Новосибирск
Russian Federation
Russian Federation
O. V. Golovanova
Учреждение Российской академии медицинских наук Научно-исследовательский институт клинической и экспериментальной лимфологии Сибирского отделения РАМН, г. Новосибирск
Russian Federation
Russian Federation
V. I. Konenkov
Учреждение Российской академии медицинских наук Научно-исследовательский институт клинической и экспериментальной лимфологии Сибирского отделения РАМН, г. Новосибирск
Russian Federation
Russian Federation
M. I. Voevoda
Учреждение Российской академии медицинских наук Научно-исследовательский институт терапии
Сибирского отделения РАМН, г. Новосибирск
Russian Federation
Russian Federation
V. N. Maximov
Учреждение Российской академии медицинских наук Научно-исследовательский институт терапии
Сибирского отделения РАМН, г. Новосибирск
Russian Federation
Russian Federation
References
1. Berberian P.A., Myers W., Tytell M., Challa V., Bond M.G. Immunohistochemical localization of heat shock protein-70 in normal-appearing and atherosclerotic specimens of human arteries // American Journal of Pathology. – 1990. – Vol. 136 (1). – P. 71-80.
2. Bland J. M., Altman D.G. Education and debate. The odds ratio // BMJ. – 2000. – Vol. 320. – P. 1468.
3. Bolla M.K., Miller G.J., Yellon D.M., Evans A., Luc G., Cambou J.P., Arveiler D., Cambien F., Latchman D.S., Humphries S.E., Day I.N. Analysis of the association of a heat shock protein70-1 gene promoter polymorphism with myocardial infarction and coronary risk traits // Dis Markers. – 1998. – Vol. 13. – P. 227-235.
4. Giacconi R., Caruso C., Lio D., Muti E., Cipriano C., Saba V., Boccoli G., Gasparini N., Malavolta M., Mocchegiani E. 1267 HSP70-2 polymorphism as a risk factor of statins on adhesion molecule expression in endothelial cells for carotid plaque rupture and cerebral ischaemia in old type 2 diabetes-atherosclerotic patients // Mech Ageing Dev. – 2005. – Vol. 126. – P. 866-873.
5. Giacconi R., Cipriano C., Muti E., Costarelli L., Malavolta M., Caruso C., Lio D., Mocchegiani E. Involvement of -308 TNF-α and 1267 Hsp70-2 polymorphisms and zinc status in the susceptibility of coronary artery disease (CAD) in old patients // Biogerontology. – 2006. – Vol. 7 (5-6). – P. 347-356.
6. He M., Guo H., Yang X., Zhang X., Zhou L., Cheng L., Zeng H., Hu F.B., Tanguay R.M., Wu T. Functional SNPs in HSPA1AGene Predict Risk of Coronary Heart Diseas // PLoS ONE – 2009. – Vol. 4 (3). – P. 4851.
7. Jayakumar J., Suzuki K., Khan M., Smolenski R.T., Farrell A., Latif N., Raisky O., Abunasra H., Sammut I.A., Murtuza B., Amrani M., Yacoub M.H. Gene transfer for myocardial protection: transfection of donor hearts with heat shock protein 70 gene protects cardiac function against ischemia-reperfusion injury // Circulation. – 2000. – Vol. 102 (3). – P. 302-306.
8. Jong P.R., Schadenberg A.W.L., Jansen N.J.G., Prakken B.J. Hsp70 and cardiac surgery: molecular chaperone and inflammatory regulator with compartmentalized effect // Cell Stress and Chaperones. – 2009. – Vol. 14. – P. 117-131.
9. Macario A. J. L., de Macario E. C. Molecular chaperones: Multiple functions, pathologies, and potential application // Frontiers in Bioscience. – 2007. – Vol. 12 (1). – P. 2588-2600.
10. Meng X., Harken A.H. The interaction between HSP70 and TNF-a expression: a novel mechanism for protection of the myocardium against post-injury depressio // Shock. – 2002. – Vol. 17 (5). – P. 345-353.
11. Milner C.M., Champell R.D. Structure and expression of the three MHC-linked HSP70
12. genes // Immunogenetics. – 1990. – Vol. 32. –
13. P. 242-251.
14. Pociot F., Ronningen K.S., Nerup J. Polymorphic analysis of the human MHC-linked heat shock protein 70 (HSP70-2) and HSP70-Hom genes in insulin-dependent diabetes mellitus (IDDM) // Scand. J. Immunol. – 1993. – Vol. 38. – P. 491-495.
15. Robitaille J., Pйrusse L., Bouchard C., Vohl M.-C. Risk Factors and Chronic Disease. Genes, Fat Intake, and Cardiovascular Disease Risk Factors in the Quebec Family Stud // Obesity. – 2007. – Vol. 15 (9). – P. 2336-2347.
16. Suzuki K., Sawa Y., Kagisaki K., Taketani S., Ichikawa H., Kaneda Y., Matsuda H. Reduction in myocardial apoptosis associated with over expression of heat shock protein 70 // Basic Res Cardiol. – 2000. – Vol. 95. – P. 397-403.
17. Zhou F., Wang F., Li F., Yuan J., Zeng H., Wei Q., Tanguay R.M, Wu T. Association of hsp70-2 and hsp-hom gene polymorphisms with risk of acute high-altitude illness in a Chinese populatio // Cell Stress Chaperones. – 2005. – Vol. 10 (4). – P. 349-356.
Review
For citations:
Shevchenko A.V., Golovanova O.V., Konenkov V.I., Voevoda M.I., Maximov V.N. FEATURES OF HSP70-2 AND HSP70-НОМ GENE POLYMORPHISM IN THE PATIENTS WITH A HISTORY OF MYOCARDIAL INFARCTION. Medical Immunology (Russia). 2011;13(1):87-92. (In Russ.) https://doi.org/10.15789/1563-0625-2011-1-87-92
Views:
765
Email this article 