CHANGES OF BLOOD CYTOKINE LEVELS IN THE COURSE OF DEVELOPING LIVER INSUFFICIENCY AFTER HEPATIC SURGERY
https://doi.org/10.15789/1563-0625-2006-1-61-66
Abstract
Abstract. The study was carried out in the patients with bulky masses in the liver. Acute hepatic failure was initiated by resection of the liver. In the patients with bulky masses in the liver, increased serum levels of the common cytokines were detected during postoperative period. The blood contents of IL-1β and IL-6 are directly dependent on the surgery-related factors (extent of resection, duration of hepatoduodenal ligation, blood loss volume), that may be employed for prediction of disease course and planning surgical treatment. Determination of a level IL-1β and IL-6 levels is a diagnostic index of liver damage, and it may be used for evaluation of the postresection hepatic failure.
About the Authors
A. N. Plekhanov
Бурятский филиал Научного центра реконструктивной и восстановительной хирургии ВСНЦ СО РАМН, г. Улан Удэ
Russian Federation
Russian Federation
S. P. Chikoteev
Научный центр реконструктивной и восстановительной хирургии ВСНЦ СО РАМН
Russian Federation
Russian Federation
F. I. Tovarshinov
Бурятский филиал Научного центра реконструктивной и восстановительной хирургии ВСНЦ СО РАМН, г. Улан Удэ
Russian Federation
Russian Federation
N. I. Soboleva
Бурятский филиал Научного центра реконструктивной и восстановительной хирургии ВСНЦ СО РАМН, г. Улан Удэ
Russian Federation
Russian Federation
References
1. Черешнев В.А., Гусев Е.Ю. Иммунология воспаления: роль цитокинов // Мед. иммунология.- 2001.- Т.3.- №3.- С.361-368.
2. Чикотеев С.П., Корнилов Н.Г., Плеханов А.Н. Интраоперационные критерии прогноза острой печеночной недостаточности при резекциях печени // Бюлл. СО РАМН.- 2001.- №2.- C. 29-33.
3. Baxevanis C.N., Papilas K., Dedoussis G.V. Abnormal cytokine serum levels correlate with impaired cellular immune responses after surgery // Clin. Immunol. Immunopathol.- 1994.-Vol. 71.-P. 82-88.
4. Cole D.J., Ferguson C.M. Complication of hepatic resection for colorectal carcinoma metastasis // Am. J. Surg.- 1992.- Vol. 58.- P.88-91.
5. Delva E., Camus Y., Hannoun L. Vascular occlusions for liver resections. Operative management and tolerance to hepatic ishemia 142 cases // Ann. Surg. – 1989. – Vol. 209. – P.211.
6. Elias D., Cavalcanti A., de Baere T. Long-term oncological results of hepatectomy performed after selective portal embolization // Ann. Chir. –1999. – Vol.53.- №7. – P. 559-564.
7. Fan S.T., Lai E.C., Lo C.M. Hepatectomy with an ultrasonic dissector for hepatocellular carcinoma // Br. J. Surg.- 1996.- Vol. 83.- P.117-120.
8. Lui W.Y, Chiu S.T, Chiu J.H. Evaluation of a simplified staging system for prognosis ofhepatocellular carcinoma // J. Formos Med. Assoc. – 1999. –Vol.98. N4. – P. 248-253.
9. Ohzato H., Yoshizaki K., Nishimoto N. Development and new indicator of interleukin-6 and C-reactive protein after surgery // Surgery.- 1988.- № 8.- P. 409-414.
10. Sasada K., Miyazaki М., Nakagawa К. Augmented enhancement of in vitro production of inflammatory cytokines in peripheral blood mononuclear cells in patients undergoing simultaneous resection of the liver and gastrointestinal tract // Crit. Care Med.- 1999.- Vol 27.- № 5. – P.361-375.
Review
For citations:
Plekhanov A.N., Chikoteev S.P., Tovarshinov F.I., Soboleva N.I. CHANGES OF BLOOD CYTOKINE LEVELS IN THE COURSE OF DEVELOPING LIVER INSUFFICIENCY AFTER HEPATIC SURGERY. Medical Immunology (Russia). 2006;8(1):61-66. (In Russ.) https://doi.org/10.15789/1563-0625-2006-1-61-66
Views:
898
Email this article 