REGULATORY TSCELLS WITH SUPPRESSIVE ACTIVITY IN SURGICAL SEPSIS
https://doi.org/10.15789/1563-0625-2006-1-51-60
Abstract
Abstract. Present work aims to investigate functioning of the regulatory T-cells with suppressor activity in surgical sepsis. It has been shown that the septic patients with decreased T cell proliferation are characterized by enhanced relative contents of СD4+СD25+ lymphocytes, including СD4-CD25high. Moreover, a reverse correlation has been revealed between СD4+CD25+high and anti-CD3-induced proliferative response of mononuclear cells (MNC).
Increased ratio of СD4+СD25+ cells is associated with arising suppressive activity of MNC, which is partially abrogated by addition of rIL-2. It should be noted that the depletion of CD25+ subpopulation is accompanied by increased T cell proliferation. Hence, a decrease in T cell proliferative activity in surgical sepsis is coupled with naturally occurring СD4+СD25+ regulatory T-cells (Trn).
Furthermore, it has been demonstrated that the suppressive activity of MNCs in septic patients is mediated by soluble factors, in particular, IL-10. Indeed, septic patients are characterized by increased level of IL-10 production and enhanced number of CD4+IL-10+ T-cells. Addition of neutralizing anti-IL-10 antibody partially abrogated the suppressive activity of MNC supernatants. Thus, our study demonstrated that inducible regulatory T cells (Tr1) coupled to the naturally occurring СD4+СD25+ regulatory T-cells (Trn) actively contribute to genesis of immune pathology in sepsis.
About the Authors
E. V. Kurganova
ГУ НИИ Клинической Иммунологии СО РАМН, Новосибирск
Russian Federation
Russian Federation
M. A. Tikhonova
ГУ НИИ Клинической Иммунологии СО РАМН, Новосибирск
Russian Federation
Russian Federation
E. I. Streltzova
Областная клиническая больница г. Новосибирск
Russian Federation
Russian Federation
A. A. Ostanin
ГУ НИИ Клинической Иммунологии СО РАМН, Новосибирск
Russian Federation
Russian Federation
E. R. Chernykh
ГУ НИИ Клинической Иммунологии СО РАМН, Новосибирск
Russian Federation
Russian Federation
V. A. Kozlov
ГУ НИИ Клинической Иммунологии СО РАМН, Новосибирск
Russian Federation
Russian Federation
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Review
For citations:
Kurganova E.V., Tikhonova M.A., Streltzova E.I., Ostanin A.A., Chernykh E.R., Kozlov V.A. REGULATORY TSCELLS WITH SUPPRESSIVE ACTIVITY IN SURGICAL SEPSIS. Medical Immunology (Russia). 2006;8(1):51-60. (In Russ.) https://doi.org/10.15789/1563-0625-2006-1-51-60
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