BLOOD MONOCYTE SUBPOPULATIONS DURING UNCOMPLICATED CORONARY ARTERY BYPASS SURGERY
https://doi.org/10.15789/1563-0625-2012-4-5-305-312
Abstract
Abstract. We have observed thirty-six patients with coronary artery disease (CAD) who have undergone coronary artery bypass graft (CABG) surgery. In patients with uncomplicated clinical course post-CABG, total lymphocyte counts, T-, B- and NK-cell contents did not significantly differ from baseline levels. Meanwhile, the numbers of CD14HIGH and CD14LOW monocyte subpopulations showed significant differences from initial levels at day 1 and day 7 after surgery. The changes in monocyte subsets in blood of patients with and absence of post-surgical septic complications reflected severity of inflammatory response, and development of systemic inflammatory syndrome. In such a case, further studies of peripheral blood monocytes can be both a useful tool for studying the mechanisms of systemic inflammation, as well as a good diagnostic system, in order to assess the patient’s condition and to predict post-surgical clinical outcomes.
About the Authors
A. S. Golovkin
НИИ комплексных проблем сердечно-сосудистых заболеваний СО РАМН, г. Кемерово
Russian Federation
Russian Federation
V. G. Matveeva
НИИ комплексных проблем сердечно-сосудистых заболеваний СО РАМН, г. Кемерово
Russian Federation
Russian Federation
I. V. Kudryavtsev
НИИ экспериментальной медицины СЗО РАМН, Санкт-Петербург
Russian Federation
Russian Federation
E. V. Grigoriev
НИИ комплексных проблем сердечно-сосудистых заболеваний СО РАМН, г. Кемерово
Russian Federation
Russian Federation
E. A. Velikanova
НИИ комплексных проблем сердечно-сосудистых заболеваний СО РАМН, г. Кемерово
Russian Federation
Russian Federation
Yu. V. Bairakova
НИИ комплексных проблем сердечно-сосудистых заболеваний СО РАМН, г. Кемерово
Russian Federation
Russian Federation
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Review
For citations:
Golovkin A.S., Matveeva V.G., Kudryavtsev I.V., Grigoriev E.V., Velikanova E.A., Bairakova Yu.V. BLOOD MONOCYTE SUBPOPULATIONS DURING UNCOMPLICATED CORONARY ARTERY BYPASS SURGERY. Medical Immunology (Russia). 2012;14(4-5):305-312. (In Russ.) https://doi.org/10.15789/1563-0625-2012-4-5-305-312
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