ANALYSIS OF CORRELATION BETWEEN IL 6 GENE POLYMORPHISM (-174 G /C) AND CLASSIC RISK FACTORS IN PATIENTS WITH PREVIOUS MYOCARDIAL INFARCTIONS
https://doi.org/10.15789/1563-0625-2009-6-557-566
Abstract
Abstract. We have carried out a prevalence analysis of IL6 (-174 G/C) gene promoter polymorphism and traditional cardiovascular risk factors in male patients living in the West Siberia that survived myocardial infarction (MI) in their anamnesis. Analysis of genotype frequencies have shown decrease of *-174 GG genotype in the patients with MI. Frequency of the same genotype is decreased among smoking patients as compared to healthy non-smokers. On other hand, an increased body weight and arterial pressure indexes increase is found in IL6*-174 G patients, versus healthy population. Hence, the analyzed IL6 (-174 G/C) polymorphism may be considered as an additional predisposition factor for development of vascular damage.
About the Authors
A. V. Shevchenko
НИИ клинической и экспериментальной лимфологии СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
O. V. Golovanova
НИИ клинической и экспериментальной лимфологии СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
V. I. Konenkov
НИИ клинической и экспериментальной лимфологии СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
M. I. Voevoda
НИИ терапии СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
V. N. Maximov
НИИ терапии СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
O. M. Tolkacheva
МУЗ Городская клиническая больница № 29, г. Новокузнецк
Russian Federation
Russian Federation
References
1. Богова О.Т., Чукаева И.И. Инфаркт миокарда. Воспаление и прогноз // Российский кардиологический журнал.– 2003. – № 4. – С. 18 - 23.
2. Доценко Э.А., Юпатов Г.И., Чиркин А.А. Холестерин и липопротеины низкой плотности как эндогенные иммуномодуляторы // Иммунопатология, аллергология, инфектология. – 2001. – № 3. – С. 6-15.
3. Лутай М.И. Атеросклероз: современный взгляд на патогенез. – http: //www.rql.kiev.ua/cardio_j/2004/1/lutay.htm.
4. Школьник В.В. Динамика уровня интерлейкина-6 у больных с острым инфарктом миокарда при лечении ингибиторами ангиотензинпревращающего фермента // Украинський терапевтичний журнал. – 2004. – № 1. – С. 74 - 76.
5. Basso F., Lowe G.D.O., Rumley A., McMahon A.D., Humphries S.E. Interleukin-6-174 G > C Polymorphism and Risk of Coronary Heart Disease in West of Scotland Coronary Prevention Study (WOSCOPS), on behalf of the WOSCOPS Group // Arterioscler Thromb. Vasc. Biol. – 2002. – Vol. 22. – P. 599-604.
6. Bennermo M., Held C., Stemme S., Ericsson C.-G., Silveira A., Green F., Tornvall P. Genetic Predisposition of the Interleukin-6 Response to Inflammation: Implications for a Variety of Major Diseases? // Clinical Chemistry. – 2004. – Vol. 50, – N 11. – P. 2136-2140.
7. Bland J. M., Altman D.G., Education and debate. The odds ratio // BMJ. – 2000. – Vol. 320. – P. 1468.
8. Brull D.J., Montgomery H.E., Sanders J., Dhamrait S., Luong L., Rumley A., Lowe G.D.O., Humphries S.E. Atherosclerosis and Lipoproteins Interleukin-6 Gene -174 G > C and -572 G > C Promoter Polymorphisms Are Strong Predictors of Plasma Interleukin-6 Levels After Coronary Artery Bypass Surgery // Arterioscler Thromb Vasc Biol.- 2001. – Vol. 21. – P. 1458-1463.
9. Crea F., Biasucci L.M., Buffon A., Liuzzo G., Monaco C., Caligiuri G., Kol A., Sperti G., Cianflone D., Maseri A. Role of inflammation in the pathogenesis of unstable coronary artery disease // Am. J. Cardiol. – 1997. – Vol. 80. – P. 10-16.
10. Fernandez-Real J.-M., Broch M., Vendrell J., Bal Richart C., Ricart W. Interleukin-6 gene polymorphism and lipid abnormalities in healthy Subjects // J. Clin. Endocrinol. Metab. – 2000. – Vol. 85. – P. 1334-1339.
11. Fernandez-Real J.-M., Vendrell J.n, Richart C., Gutierrez C., Ricart W. Platelet count and Interleukin 6 Gene polymorphism in healthy subjects // BMC Medical Genetics. – 2001. – Vol. 2, N 6. – P. 1471 - 2350.
12. Freeman D.J., Griffin B.A., Murray E. Smoking and plasma lipoproteins in man: effects on low density lipoprotein cholesterol levels and high density lipoprotein subfraction distribution // Eur. J. Clin. Invest. – 1993. – Vol. 23. – P. 630-640.
13. Gabriel A,S., Ahnve S., Wretlind B., Martinsson A. IL-6 and IL-1 receptor antagonist in stable angina pectoris and relation of IL-6 to clinical findings in acute myocardial infarction //J. Intern. Med. – 2000. – Vol. 248. – P. 61-66.
14. Cardellini M., Perego L., D’Adamo M., Marini M.A., Procopio C., Hribal M.L., Andreozzi F., Frontoni S., Giacomelli M., Paganelli M., Pontiroli A.E., Lauro R., Folli F., Sesti G. C -174G Polymorphism in the Promoter of the Interleukin-6 Gene Is Associated With Insulin Resistance // Diabetes Care. – 2005. – Vol. 28. – P. 2007-2012.
15. Georges J.-L., Loukaci V., Poirier O., Evans A.L.G., Ruidavets D.A.J.-B., Cambien F., Tiret L. Interleukin-6 gene polymorphisms and susceptibility to myocardial infarction: the ECTIM study // J. Mol. Med. – 2001. – Vol. 79. – P. 300- 305.
16. Goyenechea E., Parra D., Martínez J.A. Role of IL-6 and its-174 G > C polymorphism in weight management and in the metabolic comorbidities associated with obesity // An Sist. Sanit. Navar. – 2005. – Vol. 28, N 3. – P. 357-366.
17. Goyenechea E., Parra D., Martínez J.A. Impact of interleukin 6-174 G > C polymorphism on obesity-related metabolic disorders in people with excess in body weight // Metabolism. – 2007. – Vol. 56, N 12. – P. 1643-1648.
18. Henningsson S., Håkansson A., Westberg L., Baghaei F., Rosmond R., Holm G., Ekman A., Nissbrandt H., Eriksson E. Interleukin-6 Gene Polymorphism -174 G/C Influences Plasma Lipid Levels in Women // OBESITY. – 2006. – Vol. 14, N 11. – P. 1868-1873.
19. Humphries1 S.E., Luong1 L.A., Ogg1 M.S., Hawe1 E., Miller G.J. The interleukin-6 - 174 G/C promoter polymorphism is associated with risk of coronary heart disease and systolic blood pressure in healthy men // European Heart Journal. – 2001. – Vol. 22. – P. 2243-2252.
20. Jones K.G., Brull D.J., Brown L.C., Greenhalgh R.M., Humphries S.E., Powell J.T. Interleukin-6 (IL-6) and the Prognosis of Abdominal Aortic Aneurysms // Circulation. – 2001. – Vol. 103. – P. 2260-2265.
21. Lieb W., Pavlik R., Erdmann J., Mayer B.,Holmer S.R., Fischer M., Baessler A., Hengstenberg C., Loewel H., Doering A., Riegger G.A., Schunkert H. No association of interleukin-6 gene polymorphism (-174 G/C) with myocardial infarction or traditional cardiovascular risk factors // Int. J. Cardiol. – 2004. – Vol. 97, N 2. – P. 205-212.
22. Lowe G.D.O., Rumley A. Coagulation, fibrinolysis and cardiovascular disease // Fibrinolysis & Proteolysis. – 1999. – Vol. 13. – P. 91-98.
23. Lusis A.J., Fogelman A.M., Fonarow G.C. Genetic basis of atherosclerosis. II. Clinical implications // Circulation. – 2004. – Vol. 110. – P. 2066-2071.
24. Ridker P.M., Rifai N., Stampfer M.J., Hennekens C.H. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men // Circulation. – 2000. – Vol. 101. – P. 1767-1772.
25. Seed M., Humphries S.E., Ayres K.L., Miller G.J. Lipoprotein (a) as a predictor for myocardial infarction in the Second Northwick Park Heart Study — a prospective study in middle-aged men //Am. J. Med. – 2001. – Vol. 110. – P. 22-27.
26. Signorelli S.S., Mazzarino M.C., Di Pino L. High circulating levels of cytokines (IL-6 and TNFalpha), adhesion molecules (VCAM-1 and ICAM-1) and selectins in patients with peripheral arterial disease at rest and after a treadmill test // Vasc. Med. – 2003. – Vol. 8. – P. 15-19.
27. Takano M., Itoh N., Yayama K., Yamano M., Ohtani R.,Okamoto H. Interleukin-6 as a mediator responsible for inflammation-induced increase in plasma angiotensinogen // Biochem. Pharmacol. – 2000. – Vol. 45. – P. 201-206.
28. Tretjakovs P., Latkovskis G., Licis N., Juhnevica D., Jurka A., Bormane I., Aivars J.I., Stifts A., Pirags V. Lnterleukin-6 gene promoter -174 G/C polymorphism and insulin resistance: a pilot study // Clinical chemistry and laboratory medicine. – 2007. – Vol. 45, N 9. – P. 1145-1148.
29. Verheye S., De Meyer R.Y., Langenhove G.V. In vivo temperature heterogeneity of atherosclerotic plaques is determined by plaque composition // Circulation. – 2002. – Vol. 105, N 13. – P. 1596 - 1601.
30. Woodward M., Rumley A., Tunstall-Pedoe H., Lowe G.D.O. Associations of blood rheology and interleukin-6 with cardiovascularrisk factors and prevalent cardiovascular disease // Br. J. Haematology. – 1999. – Vol. 104. – P. 246-257.
31. Xenophontos S., Hadjivassiliou M., Karagrigoriou A., Demetriou N., Miltiadous G., Marcou I., Elisaf M., Mikhailidis D.P., Cariolou M.A. Low HDL Cholesterol, Polymorphism are Associated with Myocardial Infarction in Greek Cypriot Males. A Pilot Study // The Open Cardiovascular Medicine Journal. – 2008. – Vol. 2. – P. 52-59.
32. Yudkin J.S., Stehouwer C.D.A., Emeis J.J. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction – a potential role for cytokines originating from adipose tissue? // Arterioscler. Thromb. Vascular. Biol. – 1999. – Vol. 19. – P. 972 - 978.
Review
For citations:
Shevchenko A.V., Golovanova O.V., Konenkov V.I., Voevoda M.I., Maximov V.N., Tolkacheva O.M. ANALYSIS OF CORRELATION BETWEEN IL 6 GENE POLYMORPHISM (-174 G /C) AND CLASSIC RISK FACTORS IN PATIENTS WITH PREVIOUS MYOCARDIAL INFARCTIONS. Medical Immunology (Russia). 2009;11(6):557-566. (In Russ.) https://doi.org/10.15789/1563-0625-2009-6-557-566
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