FEATURES OF IMMUNE REACTIONS IN STRESS CONDITIONS ASSOCIATED ASSOCIATED WITH EXAMS
https://doi.org/10.15789/1563-0625-2012-1-2-133-138
Abstract
Abstract. It has been widely accepted that routine psychophysiological stressors may influence immune functioning via their close interactions between nervous, autonomic, endocrine and immune regulatory systems. The aim of this study was to evaluate immune reactions to acute psychophysiological stress in 203 medical students before and after academic exams. The results showed significant decrease of absolute and relative contents CD3+ T cells, natural killer (NK) cell subpopulations and T-NK cells (CD3-CD16+CD56+ and CD3+CD16+CD56+), as well as declined NK cell activity were revealed immediately after exams, as compared to initial values for these indices. Moreover, a significant decrease in CD19+ B cells, CD4+ T-helpers and CD8+ T-cytotoxic lymphocyte counts was found after exams, in comparison with parameters assessed under stress-free conditions, but no differences were observed, when compared with pre-examination values. Serum concentrations of IgA, IgM, IgG were within normal physiological limits. Changes in immunological parameters during acute examination-associated stress depend on characteristics of autonomous and hormonal reactions in humans, and, under particular extreme conditions, such psycho-emotional stress may cause general disturbances of immune reactions. We conclude that acute psycho-physiological stress during the exams causes significant changes in some lymphocyte subpopulations, in particular, natural killers.
About the Authors
I. V. Shirolapov
ГОУ ВПО «Самарский государственный медицинский университет» Минздравсоцразвития России, г. Самара
Russian Federation
Russian Federation
V. F. Pyatin
ГОУ ВПО «Самарский государственный медицинский университет» Минздравсоцразвития России, г. Самара
Russian Federation
Russian Federation
O. V. Lavrov
ГОУ ВПО «Самарский государственный медицинский университет» Минздравсоцразвития России, г. Самара
Russian Federation
Russian Federation
References
1. Вознесенская Т.Г. Эмоциональный стресс и профилактика его последствий // Русский медицинский журнал.– 2006.– Т. 14, № 9.– С. 694-697.
2. Крыжановский Г.Н., Магаева С.В., Макаров С.В., Сепиашвили Р.И. Нейроиммунопатология. – М.: Изд-во НИИ общей патологии и патофизиологии, 2003. – 438 с.
3. Лавров О.В., Широлапов И.В., Пятин В.Ф. Острый экзаменационный стресс: иммуносупрессия или иммуностимуляция? // Медицинская иммунология. – 2011. – Т. 13, № 4-5. – С. 470-471.
4. Anisman H. Stress, immunity, cytokines and depression // Acta Neuropsychiatrica. – 2002. – Vol. 14. – Р.251-261.
5. Atanackovic D., Schnee B., Schuch G. Acute psychological stress alerts the adaptive immune response: stress-induced mobilization of effector T cells // J. Neuroimmunol. – 2006. – Vol. 176. – Р. 141-152.
6. Besedovsky H.O., Rey A.D. Physiology of psychoneuroimmunology: a personal view // Brain. Behav. Immun. – 2007. – Vol. 21. – Р. 34-44.
7. Cohen S., Hamrick N., Rodriguez M.S., Feldman P., Rabin B., Manuck S. The stability of and intercorrelations among cardiovascular, immune, endocrine, and psychological reactivity // Ann. Behav. Med. 2000. – Vol. 22, N 3. – P. 171-179.
8. Engler H., Bailey M. T., Engler A., Sheridan J. Effects of repeated social stress on leukocyte distribution in bone marrow, peripheral blood and spleen // J. Neuroimmunol. – 2004.– Vol. 148, N 1-2. – P. 106-115.
9. Isowa T., Ohira H., Murashima S. Immune, endocrine and cardiovascular responses to controllable and uncontrollable acute stress // Biol. Psychol. – 2006. – Vol. 71. – Р. 202-213.
10. Joca S.R.L., Ferreira F.R., Guimaraes F.S. Modulation of stress consequences by hippocampal monoaminoergic, glutamatergic and nitrergic neurotransmitter systems // Stress. – 2007. – Vol. 10. – P. 227-249.
11. Keresztes M., Rudisch T., Tajti J., Ocsovszki I., Gardi J. Granulocyte activation in humans is modulated by psychological stress and relaxation // Stress. – 2007. – Vol. 10, N 3. – P. 271-281.
12. Krahwinkel T., Nastali S., Azrak B., Willershausen B. The effect of examination stress conditions on the cortisol content of saliva – a study of students from clinical semesters // Eur. J. Med. Res. – 2004. – Vol. 9, N 5. – P. 256-260.
13. Kusnecov A.W., Rossi-George A. Stressorinduced modulation of immune function: a review of acute, chronic effects in animals // Acta Neuropsychiatrica. – 2002. – Vol. 14. – Р. 279-291.
14. McEwen B.S. Physiology and Neurobiology of Stress and Adaptation: Central Role of the Brain // Physiol. Rev. – 2007. – Vol. 87. – Р. 873-904.
15. Morgan C.A., Wang S., Rasmusson A., Hazlett G., Anderson G., Charney D.S. Relationship among plasma cortisol, catecholamines, neuropeptide Y, and human performance during exposure to uncontrollable stress // Psychosom. Med. – 2001. – Vol. 63, N 3. – P. 412-422.
16. Segal A.B., Bruno S., Forte W.C. Immune function in acute stress // Allergol. Immunopathol. – 2006. – Vol. 34. – Р. 136-140.
Review
For citations:
Shirolapov I.V., Pyatin V.F., Lavrov O.V. FEATURES OF IMMUNE REACTIONS IN STRESS CONDITIONS ASSOCIATED ASSOCIATED WITH EXAMS. Medical Immunology (Russia). 2012;14(1-2):133-138. (In Russ.) https://doi.org/10.15789/1563-0625-2012-1-2-133-138
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