CYTOKINE PROFILE OF TH1- AND TH2-DEPENDENT VARIANTS OF CHRONIC GVHD
O. T. Kudaeva,
V. O. Tkachev,
E. D. Gavrilova,
E. V. Goiman,
N. N. Volsky,
O. M. Perminova,
O. P. Kolesnikova
https://doi.org/10.15789/1563-0625-2012-1-2-67-74
Abstract
Abstract. Induction of chronic GVHD in the DBA/2→(C57Bl/6xDBA/2) F1 semi-allogeneic murine model results into development of Th1- and Th2-dependent immunopathological conditions that are characterized by different cytokine profiles. Chronic GVHD is accompanied by a sharp increase in IgE levels, thus presuming considerable IL-4 production. In recipients with Th2-dependent GvHD variant, elevated contents of serum IL-6, IL-7 and TNFα were also observed, which, along with other effects, may support polyclonal activation of B cells, thus leading to development of autoimmune pathology.
About the Authors
O. T. Kudaeva
НИИ клинической иммунологии СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
V. O. Tkachev
НИИ клинической иммунологии СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
E. D. Gavrilova
НИИ клинической иммунологии СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
E. V. Goiman
НИИ клинической иммунологии СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
N. N. Volsky
НИИ клинической иммунологии СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
O. M. Perminova
НИИ клинической иммунологии СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
O. P. Kolesnikova
НИИ клинической иммунологии СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
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Review
For citations:
Kudaeva O.T., Tkachev V.O., Gavrilova E.D., Goiman E.V., Volsky N.N., Perminova O.M., Kolesnikova O.P. CYTOKINE PROFILE OF TH1- AND TH2-DEPENDENT VARIANTS OF CHRONIC GVHD. Medical Immunology (Russia). 2012;14(1-2):67-74. (In Russ.) https://doi.org/10.15789/1563-0625-2012-1-2-67-74
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ISSN 2313-741X (Online)
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