ANTI-ERGOTYPIC RESPONSE: ROLE IN NORMAL IMMUNE RESPONSE AND AUTOIMMUNE PATHOLOGY IN EXPERIMENTAL MODEL
https://doi.org/10.15789/1563-0625-2011-1-29-34
Abstract
Abstract. Anti-ergotypic cells are a part of peripheral regulatory network, and they are thought to control autoreactive T cells by recognition of certain clonotypic and ergotypic determinants on the surface of activated T cells. The aim of our study was to investigate ability of anti-CD3 activated syngeneic splenocytes to induce anti-ergotypic response and to assess immune response in delayed-type hypersensitivity (DTH) reaction.DTH response in experimental group was significantly greater than in control and intact groups. Upon crossadministration, DTH response was minimal and there were no significant differences between the groups. No changes in cellular and humoral immune response were observed under such conditions. These results suggest a development of immune response to activated antigen-nonspecific cells. In a model of chronic GvHD, donor immunization was shown to exert a protective effect, with regard of proteinuria dynamics in recipients, whereas immunization of recipients did not alter the GvHD dynamics. (Med. Immunol., 2011, vol. 13, N 1, pp 29-34)
About the Authors
N. A. Ilyina
НИИКИ СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
E. V. Goiman
НИИКИ СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
O. T. Kudaeva
НИИКИ СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
O. P. Kolesnikova
НИИКИ СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
V. S. Kozhevnikov
НИИКИ СО РАМН, г. Новосибирск
Russian Federation
Russian Federation
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Review
For citations:
Ilyina N.A., Goiman E.V., Kudaeva O.T., Kolesnikova O.P., Kozhevnikov V.S. ANTI-ERGOTYPIC RESPONSE: ROLE IN NORMAL IMMUNE RESPONSE AND AUTOIMMUNE PATHOLOGY IN EXPERIMENTAL MODEL. Medical Immunology (Russia). 2011;13(1):29-34. (In Russ.) https://doi.org/10.15789/1563-0625-2011-1-29-34
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